Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Март 18, 2024
The
global
challenge
posed
by
cancer,
marked
rising
incidence
and
mortality
rates,
underscores
the
urgency
for
innovative
therapeutic
approaches.
PI3K/Akt
signaling
pathway,
frequently
amplified
in
various
cancers,
is
central
regulating
essential
cellular
processes.
Its
dysregulation,
often
stemming
from
genetic
mutations,
significantly
contributes
to
cancer
initiation,
progression,
resistance
therapy.
Concurrently,
ferroptosis,
a
recently
discovered
form
of
regulated
cell
death
characterized
iron-dependent
processes
lipid
reactive
oxygen
species
buildup,
holds
implications
diseases,
including
cancer.
Exploring
interplay
between
dysregulated
pathway
ferroptosis
unveils
potential
insights
into
molecular
mechanisms
driving
or
inhibiting
ferroptotic
cells.
Evidence
suggests
that
may
sensitize
cells
induction,
offering
promising
strategy
overcome
drug
resistance.
This
review
aims
provide
comprehensive
exploration
this
interplay,
shedding
light
on
disrupting
enhance
as
an
alternative
route
inducing
improving
treatment
outcomes.
Cell Death Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Янв. 18, 2025
A
new
type
of
nonapoptotic,
iron-dependent
cell
death
induced
by
lipid
peroxidation
is
known
as
ferroptosis.
Numerous
pathological
processes,
including
inflammation
and
cancer,
have
been
demonstrated
to
be
influenced
changes
in
the
ferroptosis-regulating
network.
Long
non-coding
RNAs
(LncRNAs)
are
a
group
functional
RNA
molecules
that
not
translated
into
proteins,
which
can
regulate
gene
expression
various
manners.
An
increasing
number
studies
shown
lncRNAs
interfere
with
progression
ferroptosis
modulating
ferroptosis-related
genes
directly
or
indirectly.
Despite
evidence
implicating
cancer
inflammation,
on
their
mechanisms
therapeutic
potential
remain
scarce.
We
investigate
lncRNA-mediated
regulation
immunity,
assessing
feasibility
challenges
targets
these
conditions.
Journal of Advanced Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
The
invasion
and
metastasis
of
pancreatic
cancer
(PC)
are
key
factors
contributing
to
disease
progression
poor
prognosis.
This
process
is
primarily
driven
by
EMT,
which
has
been
the
focus
recent
studies
highlighting
role
long
non-coding
RNAs
(lncRNAs)
as
crucial
regulators
EMT.
However,
mechanisms
lncRNAs
influence
invasive
multifaceted,
extending
beyond
EMT
regulation
alone.
review
aims
characterize
affecting
in
cancer.
We
summarize
regulatory
roles
across
multiple
molecular
pathways
highlight
their
translational
potential,
considering
implications
for
clinical
applications
diagnostics
therapeutics.
focuses
on
three
principal
scientific
themes.
First,
we
orchestrate
various
signaling
pathways,
such
TGF-β/Smad,
Wnt/β-catenin,
Notch,
regulate
changes
associated
with
thereby
enhancing
cellular
motility
invasivenes.
Second,
effects
autophagy
ferroptosis
discuss
exosomal
tumor
microenvironment
behavior
neighboring
cells
promote
cell
invasion.
Third,
emphasize
RNA
modifications
(such
m6A
m5C
methylation)
stabilizing
capacity
mediate
PC.
Lastly,
potential
these
findings,
emphasizing
inherent
challenges
using
biomarkers
therapeutic
targets,
while
proposing
prospective
research
strategies.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13336 - 13336
Опубликована: Авг. 28, 2023
As
a
novel
form
of
regulated
cell
death,
ferroptosis
is
characterized
by
intracellular
iron
and
lipid
peroxide
accumulation,
which
different
from
other
death
forms
morphologically,
biochemically,
immunologically.
Ferroptosis
metabolism,
antioxidant
defense
systems
as
well
various
transcription
factors
related
signal
pathways.
Emerging
evidence
has
highlighted
that
associated
with
many
physiological
pathological
processes,
including
cancer,
neurodegeneration
diseases,
cardiovascular
ischemia/reperfusion
injury.
Noncoding
RNAs
are
group
functional
RNA
molecules
not
translated
into
proteins,
can
regulate
gene
expression
in
manners.
An
increasing
number
studies
have
shown
noncoding
RNAs,
especially
miRNAs,
lncRNAs,
circRNAs,
interfere
the
progression
modulating
ferroptosis-related
genes
or
proteins
directly
indirectly.
In
this
review,
we
summarize
basic
mechanisms
regulations
focus
on
recent
mechanism
for
types
ncRNAs
to
conditions,
will
deepen
our
understanding
regulation
provide
new
insights
employing
ferroptosis-associated
therapeutic
strategies.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 20
Опубликована: Ноя. 24, 2022
Hepatocellular
carcinoma
(HCC)
is
a
prevalent
malignant
tumor
worldwide.
Ferroptosis
emerging
as
an
effective
target
for
treatment
it
has
been
shown
to
potentiate
cell
death
in
some
malignancies.
However,
remains
unclear
whether
histone
phosphorylation
events,
epigenetic
mechanism
that
regulates
transcriptional
expression,
are
involved
ferroptosis.
Our
study
found
supplementation
with
anisomycin,
agonist
of
p38
mitogen-activated
protein
kinase
(MAPK),
induced
ferroptosis
HCC
cells,
and
the
H3
on
serine
10
(p-H3S10)
was
participated
anisomycin-induced
To
investigate
anticancer
effects
anisomycin-activated
MAPK
HCC,
we
analyzed
viability,
colony
formation,
death,
migration
Hep3B
HCCLM3
cells.
The
results
showed
anisomycin
could
significantly
suppress
formation
induce
death.
hallmarks
ferroptosis,
such
abnormal
accumulation
iron
elevated
levels
lipid
peroxidation
malondialdehyde,
were
detected
confirm
ability
promote
Furthermore,
coincubation
SB203580,
inhibitor
activated
MAPK,
partially
rescued
And
p-p38
p-H3S10
successively
increased
by
treatment.
relationship
between
revealed
ChIP
sequencing.
reverse
transcription
PCR
immunofluorescence
NCOA4
upregulated
both
mRNA
after
C11-BODIPY
staining,
reactive
oxygen
species
reduced
knockdown.
In
conclusion,
promoted
cells
through
H3S10
phosphorylation.
Cell Biology and Toxicology,
Год журнала:
2025,
Номер
41(1)
Опубликована: Март 20, 2025
Abstract
Background
Exosome
Lnc
A2M-AS1
from
olfactory
mucosa
mesenchymal
stem
cells
(OM-MSCs)
can
ameliorate
oxidative
stress
by
improving
mitophagy
in
cardiomuscular
cells;
however,
it
remains
unclear
whether
this
effect
exists
the
brain
tissues
of
patients
with
Parkinson’s
disease
(PD).
Methods
OM-MSC–Exosomes
were
isolated
and
verified
based
on
morphology
specific
biomarkers.
The
effects
OM-MSC-Exo
mitochondrial
autophagy,
stress,
lncRNA
detected
MPP
+
-treated
HT22
cells.
OM-MSC-Exos
autophagy
an
MPTP-induced
Parkinson's
(PD)
model
C57BL/6
mice.
interaction
between
IGF2BP1,
A2M-AS1,
TP53INP1
was
assessed
via
RNA
pull-down/RNA
Immunoprecipitation
stability
assays.
lnc
IGF2BP1/TP53INP1-mediated
PD
mouse
models.
Results
Exosomes
found
to
be
rich
A2M-AS1.
proved
able
induced
regulates
enhancing
In
addition,
through
mediated
expression
binding
IGF2BP1.
Furthermore,
treatment
improved
symptoms
ameliorated
Conclusion
Collectively,
OM-MSC-derived
exosomes
targeting
IGF2BP1
induce
stress.
could
potentially
serve
as
promising
candidates
for
new
methods
PD.
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