European Journal of Pharmacology, Год журнала: 2023, Номер 957, С. 176027 - 176027
Опубликована: Авг. 31, 2023
Язык: Английский
ACS Chemical Neuroscience, Год журнала: 2023, Номер 14(10), С. 1717 - 1763
Опубликована: Май 8, 2023
Gut microbiota includes a vast collection of microorganisms residing within the gastrointestinal tract. It is broadly recognized that gut and brain are in constant bidirectional communication, which its metabolic production major component, form so-called microbiome–brain axis. Disturbances homeostasis caused by imbalance their functional composition activities, known as dysbiosis, cause dysregulation these pathways trigger changes blood–brain barrier permeability, thereby causing pathological malfunctions, including neurological disorders. In turn, can affect structure function through autonomic nervous system regulating motility, intestinal transit secretion, permeability. Here, we examine data from CAS Content Collection, largest published scientific information, analyze publication landscape recent research. We review advances knowledge related to human microbiome, complexity functionality, communication with central system, effect axis on mental health. discuss correlations between various diseases, specifically also explore metabolites regard impact associated diseases. Finally, assess clinical applications gut-microbiota-related substances development pipelines. hope this serve useful resource understanding current emerging field an effort further solving remaining challenges fulfilling potential.
Язык: Английский
Процитировано
96
Cell Genomics, Год журнала: 2025, Номер unknown, С. 100768 - 100768
Опубликована: Фев. 1, 2025
Emerging research underscores the gut microbiome's impact on nervous system via microbiota-gut-brain axis, yet comprehensive insights remain limited. Using a CHD8-haploinsufficient model for autism spectrum disorder (ASD), we explored host-gut microbiota interactions by constructing single-cell transcriptome atlas of brain and intestinal tissues in wild-type mutant mice across three developmental stages. CHD8 haploinsufficiency caused delayed development radial glial precursors excitatory neural progenitors E14.5 brain, inflammation adult immunodeficiency, abnormal development. Selective knockdown epithelial cells generated Chd8ΔIEC mice, which exhibited normal sociability but impaired social novelty recognition. Probiotic intervention with Lactobacillus murinus selectively rescued deficits analysis revealing underlying mechanisms. This study provides detailed transcriptomic dataset ASD-related changes, advancing our understanding gut-brain axis offering potential therapeutic strategies ASD.
Язык: Английский
Процитировано
2
Nature Mental Health, Год журнала: 2024, Номер 2(8), С. 935 - 950
Опубликована: Июнь 21, 2024
Язык: Английский
Процитировано
9
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 172, С. 116267 - 116267
Опубликована: Фев. 16, 2024
Schizophrenia (SCZ) is a psychotic mental disorder characterized by cognitive, behavioral, and social impairments. However, current pharmacological treatment regimens are subpar in terms of effectiveness. This study aimed to investigate the function Radix Bupleuri aqueous extract SCZ mouse models. The model was established MK-801 injection feeding or combined antibiotics. significantly improved aberrant behaviors neuronal damage mice, upregulated SYP PSD-95 expression BDNF levels hippocampal homogenates, down-regulated DA 5-HT levels, suppressed microglial activation mice. Moreover, integrity intestinal tract barrier. 16 S rRNA sequencing feces showed that modulated composition gut flora. Lactobacillus abundance decreased mice reversed administration which exhibited significant negative correlation with IL-6, IL-1β, DA, 5-HT, positive tissues. Parabacteroides Alloprevotella increased It administration, BDNF. In conclusion, attenuates inflammatory response tissues modulates neurotransmitter exerting its neuroprotective effect SCZ. Meanwhile, alteration flora may be involved this process, expected an underlying therapeutic option treating
Язык: Английский
Процитировано
8
Pharmacological Research, Год журнала: 2025, Номер 213, С. 107654 - 107654
Опубликована: Фев. 12, 2025
Язык: Английский
Процитировано
1
Life, Год журнала: 2024, Номер 14(10), С. 1234 - 1234
Опубликована: Сен. 26, 2024
Microbes have inhabited the earth for hundreds of millions years longer than humans. The microbiota-gut-brain axis (MGBA) represents a bidirectional communication pathway. These communications occur between central nervous system (CNS), enteric (ENS), and emotional cognitive centres brain. field research on gut-brain has grown significantly during past two decades. Signalling occurs gut microbiota brain through neural, endocrine, immune, humoral pathways. A substantial body evidence indicates that MGBA plays pivotal role in various neurological diseases. include Alzheimer's disease (AD), autism spectrum disorder (ASD), Rett syndrome, attention deficit hyperactivity (ADHD), non-Alzheimer's neurodegeneration dementias, fronto-temporal lobe dementia (FTLD), Wilson-Konovalov (WD), multisystem atrophy (MSA), Huntington's chorea (HC), Parkinson's (PD), multiple sclerosis (MS), amyotrophic lateral (ALS), temporal epilepsy (TLE), depression, schizophrenia (SCZ). Furthermore, correlation therapeutics will be discussed. Conversely, mood delivery, exercise, psychotropic agents, stress, neurologic drugs can influence MGBA. By understanding MGBA, it may possible to facilitate into microbial-based interventions therapeutic strategies
Язык: Английский
Процитировано
7
Journal of Ethnopharmacology, Год журнала: 2024, Номер 328, С. 118066 - 118066
Опубликована: Март 16, 2024
Gynostemma pentaphyllum (Thunb.) Makino has traditional applications in Chinese medicine to treat lipid abnormalities. Gypenosides (GPs), the main bioactive components of pentaphyllum, have been reported exert hypolipidemic effects through multiple mechanisms. The lipid-lowering GPs may be attributed aglycone portion resulting from hydrolysis by gut microbiota. However, date, there no reports on whether gypenoside aglycones (Agl), primary constituents, can ameliorate hyperlipidemia modulating
Язык: Английский
Процитировано
5
Translational Psychiatry, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 1, 2025
Gut microbiome is implicated in the onset and progression of major depressive disorder (MDD), but dynamic alterations symptoms, gut microbiome, fecal metabolome across different stages stress exposure remain unclear. Here, we modified chronic social defeat (CSDS) model to evaluate mice subjected for 1, 4, 7, 10 days. Behavioral tests, 16S rRNA, metagenomics, metabolomics were conducted investigate impact on behaviors, microbiota metabolites. We observed that depressive-like such as anhedonia avoidance, worsened significantly increased. The microbial composition, function, metabolites exhibited distinct separations groups. Mediation analysis identified key bacteria, Lachnospiraceae_UCG-001 Bacteroidetes, like valeric acid N-acetylaspartate. In our clinical depression cohort, confirmed levels, lower MDD patients, correlating closely with mice. Further serum brain revealed sustained changes N-acetylaspartate abundance fecal, serum, cortical samples following increasing exposure. Together, this study elucidated characteristics various exposure, bacteria potentially involved modulating response providing new insights into pathogenesis intervention depression.
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2024, Номер 16(17), С. 2856 - 2856
Опубликована: Авг. 26, 2024
The medicinal properties of resveratrol have garnered increasing attention from researchers. Extensive data been accumulated on its use in treating cardiovascular diseases, immune system disorders, cancer, neurological and behavioral disorders. protective mechanisms resveratrol, particularly anxiety-related stress well documented. However, less has given to the side effects resveratrol. This review explores not only underlying anxiolytic but also that may lead increased anxiety following treatment. Understanding these is crucial for enhancing efficacy managing disorders associated with PTSD.
Язык: Английский
Процитировано
3
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2024, Номер 132, С. 110966 - 110966
Опубликована: Фев. 13, 2024
Язык: Английский
Процитировано
2