Cells,
Год журнала:
2023,
Номер
12(20), С. 2485 - 2485
Опубликована: Окт. 19, 2023
Three
systemic
biological
systems,
i.e.,
the
nervous,
immune,
and
cardiovascular
form
a
mutually
responsive
forward-acting
tissue
network
to
regulate
acute
chronic
function
in
health
disease.
Two
sub-circuits
within
system
have
been
described,
artery
brain
circuit
(ABC)
heart
(HBC),
forming
large
(CBC).
Likewise,
nervous
consists
of
peripheral
central
with
their
functional
distinct
sensory
effector
arms.
Moreover,
immune
its
constituents,
innate
adaptive
interact
CBC
at
multiple
levels.
As
understanding
structure
inner
workings
gains
momentum,
it
becomes
evident
that
further
research
into
may
lead
unprecedented
classes
therapies
treat
diseases
as
new
biologically
active
molecules
are
being
discovered
likely
affect
disease
progression.
Here,
we
weigh
merits
integrating
these
recent
observations
neurobiology
previous
views
pathogeneses.
These
considerations
us
propose
Neuroimmune
Cardiovascular
Circuit
Hypothesis.
Cell Reports,
Год журнала:
2024,
Номер
43(4), С. 113953 - 113953
Опубликована: Март 21, 2024
The
gastrointestinal
(GI)
tract
is
innervated
by
intrinsic
neurons
of
the
enteric
nervous
system
(ENS)
and
extrinsic
central
peripheral
ganglia.
GI
also
harbors
a
diverse
microbiome,
but
interactions
between
ENS
microbiome
remain
poorly
understood.
Here,
we
activate
choline
acetyltransferase
(ChAT)-expressing
or
tyrosine
hydroxylase
(TH)-expressing
gut-associated
in
mice
to
determine
effects
on
intestinal
microbial
communities
their
metabolites
as
well
host
physiology.
resulting
multi-omics
datasets
support
broad
roles
for
discrete
neuronal
subtypes
shaping
structure,
including
modulating
bile
acid
profiles
fungal
colonization.
Physiologically,
activation
either
ChAT+
TH+
increases
fecal
output,
while
only
results
increased
colonic
contractility
diarrhea-like
fluid
secretion.
These
findings
suggest
that
specific
subsets
peripherally
activated
differentially
regulate
gut
physiology
without
involvement
signals
from
brain.
Circulation Research,
Год журнала:
2025,
Номер
136(6), С. 618 - 627
Опубликована: Март 13, 2025
Neurocardiology
is
an
interdisciplinary
field
that
examines
the
complex
interactions
between
nervous
and
cardiovascular
systems,
exploring
how
neurological
processes,
such
as
autonomic
system
regulation
brain-heart
communication
impact
heart
function
contribute
to
health
disease.
Although
much
of
focus
on
has
centered
traditional
risk
factors,
influence
system,
especially
in
females,
increasingly
recognized
a
key
determinant
outcomes.
This
article
reviews
existing
literature
mechanisms
females.
Specifically,
we
analyze
primary
disorders
including
cerebrovascular
disease,
headache
disorders,
multiple
sclerosis
have
specific
downstream
effects
cardiac
function.
By
understanding
relationship
health,
this
review
highlights
need
for
sex-specific
approaches
prevention,
diagnosis,
treatment
disease
ultimately
encouraging
discovery
more
effective
care
strategies
improving
Circulation Research,
Год журнала:
2024,
Номер
134(10), С. 1348 - 1378
Опубликована: Май 9, 2024
Loss
or
dysregulation
of
the
normally
precise
control
heart
rate
via
autonomic
nervous
system
plays
a
critical
role
during
development
and
progression
cardiovascular
disease-including
ischemic
disease,
failure,
arrhythmias.
While
clinical
significance
regulating
changes
in
rate,
known
as
chronotropic
effect,
is
undeniable,
mechanisms
controlling
these
remain
not
fully
understood.
Heart
acceleration
deceleration
are
mediated
by
increasing
decreasing
spontaneous
firing
pacemaker
cells
sinoatrial
node.
During
transition
from
rest
to
activity,
sympathetic
neurons
stimulate
activating
β-adrenergic
receptors
intracellular
cyclic
adenosine
monophosphate.
The
same
signal
transduction
pathway
targeted
positive
drugs
such
norepinephrine
dobutamine,
which
used
treatment
cardiogenic
shock
severe
failure.
monophosphate-sensitive
hyperpolarization-activated
current
(I
Abstract
Cardiac
function
is
under
neural
regulation;
however,
brain
regions
in
the
cerebral
cortex
responsible
for
regulating
cardiac
remain
elusive.
In
this
study,
retrograde
trans‐synaptic
viral
tracing
used
from
heart
to
identify
a
specific
population
of
excitatory
neurons
primary
motor
(M1)
that
influences
mice.
Optogenetic
activation
M1
glutamatergic
increases
rate,
ejection
fraction,
and
blood
pressure.
By
contrast,
inhibition
decreased
pressure
as
well
tyrosine
hydroxylase
(TH)
expression
heart.
Using
optogenetics,
median
raphe
nucleus
(MnR)
identified
one
key
relay
circuit
affect
function.
Then,
mouse
model
injury
established
caused
by
myocardial
infarction
(MI),
which
optogenetic
impaired
MI
Moreover,
ablation
levels
norepinephrine
TH
expression,
enhanced
These
findings
establish
involved
regulation
They
also
help
understanding
mechanisms
underlying
cardiovascular
regulation.
Cardiovascular Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 24, 2024
Abstract
The
importance
of
the
brain–heart
interaction
has
been
increasingly
recognized
as
a
critical
physiological
axis
that
is
altered
in
disease.
In
this
review,
we
explore
intricate
relationship
between
central
nervous
system
and
cardiovascular
health,
focusing
particularly
on
immunological
mechanisms
influence
course
both
neurological
diseases.
While
previous
studies
have
established
key
role
autonomic
(ANS)
linking
brain
heart,
more
recent
expanded
our
understanding
multifaceted
inter-organ
interactions.
As
such,
circulating
mediators
include
immune
cells
adaptive
innate
their
secreted
immunogenic
factors
come
into
focus
along
bidirectional
communication.
Hence,
review
briefly
discuss
contribution
ANS
then
heart-to-brain
brain-to-heart
axes,
illustrating
how
diseases
affect
cognitive
functions
pathologies
lead
to
cardiac
complications.
Circulation Research,
Год журнала:
2025,
Номер
136(3), С. 325 - 353
Опубликована: Янв. 30, 2025
Cardiovascular
and
cardiometabolic
diseases
are
leading
causes
of
morbidity
mortality
worldwide,
driven
in
part
by
chronic
inflammation.
Emerging
research
suggests
that
the
bone
marrow
microenvironment,
or
niche,
plays
a
critical
role
both
immune
system
regulation
disease
progression.
The
niche
is
essential
for
maintaining
hematopoietic
stem
cells
(HSCs)
orchestrating
hematopoiesis.
Under
normal
conditions,
this
ensures
return
to
homeostasis
after
acute
stress.
However,
setting
inflammatory
conditions
such
as
those
seen
diseases,
it
becomes
dysregulated,
enhanced
myelopoiesis
activation.
This
review
explores
reciprocal
relationship
between
highlighting
how
alterations
contribute
development
regulates
HSCs
through
complex
interactions
with
stromal
cells,
endothelial
signaling
molecules.
hypertension,
atherosclerosis,
diabetes,
signals
disrupt
balance
HSC
self-renewal
differentiation,
promoting
excessive
production
proinflammatory
myeloid
exacerbate
disease.
Key
mechanisms
discussed
include
effects
hyperlipidemia,
hyperglycemia,
sympathetic
nervous
activation
on
proliferation
differentiation.
Furthermore,
emphasizes
epigenetic
modifications
metabolic
reprogramming
creating
trained
immunity,
phenomenon
whereby
acquire
long-term
characteristics
sustain
states.
Finally,
we
explore
therapeutic
strategies
aimed
at
targeting
mitigate
inflammation
its
sequelae.
Novel
interventions
modulate
hematopoiesis
restore
hold
promise
treatment
diseases.
By
interrupting
vicious
cycle
dysregulation,
therapies
may
offer
new
avenues
reducing
cardiovascular
risk
improving
patient
outcomes.
