Physical activity and exercise health benefits: cancer prevention, interception, and survival

European Journal of Cancer Prevention, Год журнала: 2024, Номер 34(1), С. 24 - 39

Опубликована: Май 29, 2024

Physical activity (PA) has an established role in the promotion of health and fitness prevention disease. Expected overall benefits include reduction all-cause morbidity death, weight control, improved quality life, bone decreased falls elderly subjects, , deeper cognition, reduced risk depression, anxiety, sleeplessness. Currently, PA is a mainstay management cardiovascular diseases, metabolic syndrome, diabetes, health. Recently, perception its primary secondary prevention, interception, treatment cancer, however, also gaining importance. Regular walking, simplest type PA, associated with disease mortality, cancer increasing interest. Furthermore, improves life patients, attenuating side effects chemotherapy, decreasing sarcopenia, fitness, inhibiting recurrence progression some types. It promotes emotional psychological inducing positive changes. While mechanisms, effective levels useful amount practice are well cardiology, they yet to be fully determined oncology. Nevertheless, recommended reduce general population, it been introduced programs for second cancers. In perspective, will help as integrative therapy patients survivors. The number beneficial continuum highlighted this review.

Язык: Английский

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Dantrolene as a Potential Strategy to Prevent Doxorubicin-Induced Cardiotoxicity

JACC CardioOncology, Год журнала: 2025, Номер 7(1), С. 53 - 55

Опубликована: Янв. 1, 2025

Язык: Английский

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Cytotoxic T cells drive doxorubicin-induced cardiac fibrosis and systolic dysfunction

Nature Cardiovascular Research, Год журнала: 2024, Номер 3(8), С. 970 - 986

Опубликована: Июль 17, 2024

Язык: Английский

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Multi-omics uncovers immune-modulatory molecules in plasma contributing to resistance exercise-ameliorated locomotor disability after incomplete spinal cord injury

Genome Medicine, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 5, 2025

Exercise rehabilitation therapy has garnered widespread recognition for its beneficial effects on the restoration of locomotor function in individuals with spinal cord injury (SCI). Notably, resistance exercise demonstrated significant improvements muscle strength, coordination, and overall functional recovery. However, to optimize clinical management mimic exercise-like effects, it is imperative obtain a comprehensive understanding molecular alterations that underlie these positive effects. We conducted randomized controlled trial investigating incomplete SCI. integrated analysis plasma proteomics peripheral blood mononuclear cells (PBMC) transcriptomics explore cellular changes induced by exercise. Subsequently, we established weight-loaded ladder-climbing mouse model physiological exercise, analyzed proteome metabolome, as well transcriptomes PBMC tissue. Lastly, confirm transmissibility neuroprotective intravenously injected obtained from exercised male mice into SCI female during non-acute phase. Plasma proteomic transcriptomic profiling underscored notable involvement complement pathways humoral immune response process restoring following human trial. Moreover, was emphasized interventions could effectively modulate pathways. Through employing tissues mice, our study revealed immunomodulatory responses parallel those observed trials. In addition, metabolomics an enhancement lipid metabolism exhibited ameliorating disability after via reducing demyelination inhibiting neuronal apoptosis. Our investigation elucidates associated promoting recovery demonstrate direct delivered injection, which facilitates repair. Mechanistically, multi-omics involving both reveals principal constituents responsible within are predominantly immunoregulatory factors, warranting further experimental validation. The retrospectively registered 17 July, 2024, Chinese Clinical Trial Registry (No.: ChiCTR2400087038) at https://www.chictr.org.cn/ .

Язык: Английский

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The role of HDAC2 inhibition in cardioprotection against doxorubicin-induced myocardial injury

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12

Опубликована: Фев. 26, 2025

The molecular mechanisms underlying cardioprotection against doxorubicin (DOX)-induced myocardial injury are poorly understood. Histone deacetylase 2 (HDAC2) plays a significant role in oxidative stress, apoptosis, and mitochondrial dysfunction is implicated many human diseases, This study investigated the relationship between HDAC2 expression DOX-induced using vivo rat model of cardiotoxicity vitro experiments with H9c2 cardiomyocytes. was established by administering DOX via intraperitoneal injections. suppressed rats sodium butyrate (SB) Echocardiography measurements were performed at baseline on day 15 post-treatment. euthanized cardiac tissues harvested. tissue samples analyzed hematoxylin eosin H&E staining, immunohistochemistry, Masson Sirius Red TUNEL western blotting to determine status apoptosis. In experiments, cells treated DOX. or transfected shRNA knockdown (shHDAC2). from different groups Rt-qPCR, CCK-8 cell viability assay, cardiomyocyte treatment induced rats. DOX-treated showed significantly higher levels compared corresponding controls. However, inhibition mitigated suggested strong association injury. cells, shHDAC2 alleviated apoptosis enhacing AKT phosphorylation. These findings demonstrated that silencing protected activating PI3K/AKT signaling pathway. Suppressing Therefore, promising therapeutic target for mitigating

Язык: Английский

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Swimming training attenuates doxorubicin induced cardiomyopathy by targeting the mir-17-3p/KEAP1/NRF2 axis

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 739, С. 150568 - 150568

Опубликована: Авг. 19, 2024

Язык: Английский

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Intraperitoneal administration of doxorubicin-encapsulated Brucea javanica oil nanoemulsion against malignant ascites

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 202, С. 114422 - 114422

Опубликована: Июль 20, 2024

Язык: Английский

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Improvement of the Immunity System Through Sports: Novel Regulatory Mechanisms for Hypertension

Reviews in Cardiovascular Medicine, Год журнала: 2024, Номер 25(10)

Опубликована: Окт. 25, 2024

Hypertension and its resulting target organ damage is a complex process associated with range of physiological molecular factors, including immune regulation. The profound effects exercise on normal system function the development progression hypertension are well known. This review aims to create new avenues for preventing treating damage. narrative emphasizes role training in prevention/treatment through response modulation presents current perspectives available scientific evidence. Several studies have shown that regulates by altering cells, which partly attributable anti-inflammatory training. Regular modifies could represent mechanism regulating hypertension. Although utilization conjunction still early stages, literature indicates numerous potential links between training, system,

Язык: Английский

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Macrophage metabolic reprogramming: A trigger for cardiac damage in autoimmune diseases

Autoimmunity Reviews, Год журнала: 2024, Номер unknown, С. 103733 - 103733

Опубликована: Дек. 1, 2024

Язык: Английский

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B-Cell Immune Checkpoints Come of Age in Cardio-oncology

Circulation Research, Год журнала: 2024, Номер 134(5), С. 569 - 571

Опубликована: Фев. 29, 2024

Язык: Английский

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