Transcranial Direct Current Stimulation to Ameliorate Post-Stroke Cognitive Impairment
Brain Sciences,
Год журнала:
2024,
Номер
14(6), С. 614 - 614
Опубликована: Июнь 19, 2024
Post-stroke
cognitive
impairment
is
a
common
and
disabling
condition
with
few
effective
therapeutic
options.
After
stroke,
neural
reorganization
other
neuroplastic
processes
occur
in
response
to
ischemic
injury,
which
can
result
clinical
improvement
through
spontaneous
recovery.
Neuromodulation
transcranial
direct
current
stimulation
(tDCS)
promising
intervention
augment
underlying
neuroplasticity
order
improve
function.
This
form
of
neuromodulation
leverages
mechanisms
post-stroke
optimize
In
this
review,
we
summarize
the
state
neurorehabilitation
post-stroke,
practical
features
tDCS,
its
uses
stroke-related
across
domains,
special
considerations
for
use
tDCS
patient
population.
Язык: Английский
Aerobic exercise, an effective intervention for cognitive impairment after ischemic stroke
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Апрель 4, 2025
Cognitive
dysfunction
is
a
common
and
debilitating
complication
following
ischemic
stroke,
significantly
impairing
the
quality
of
life
patients.
In
recent
years,
aerobic
exercise
has
emerged
as
promising
non-pharmacological
intervention
to
mitigate
post-stroke
cognitive
impairment
(PSCI).
This
review
synthesizes
current
evidence
on
efficacy
mechanisms
in
enhancing
recovery
after
stroke.
Key
include
improved
cerebral
hemodynamics
through
enhanced
blood
flow
(CBF),
promotion
neuroplasticity
via
brain-derived
neurotrophic
factor
(BDNF)-mediated
pathways,
suppression
neuroinflammation
(e.g.,
NLRP3
inflammasome
inhibition),
attenuation
oxidative
stress.
Preclinical
clinical
studies
demonstrate
that
modalities
such
gait
training,
cycling,
aquatic
therapy
enhance
domains
including
memory,
executive
function,
attention,
with
optimal
benefits
observed
at
moderate-to-high
intensity
frequency
≥3
sessions
per
week.
Despite
robust
evidence,
challenges
remain
standardizing
protocols
addressing
individual
variability
treatment
response.
Future
research
should
prioritize
large-scale
randomized
controlled
trials
validate
long-term
identify
biomarkers
for
personalized
rehabilitation
strategies.
underscores
imperative
integrate
into
paradigms,
offering
dual
therapeutic
approach
improve
both
physical
outcomes.
Язык: Английский
Large inter-arm systolic blood pressure difference is associated with cognitive impairment in older adults: a cross-sectional study in rural southwest China
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Апрель 14, 2025
Background
Studies
have
shown
that
both
inter-arm
blood
pressure
difference
(IABPD)
and
cognitive
impairment
are
associated
with
vascular
events.
However,
the
relationship
between
IABPD
among
elderly
individuals
in
rural
China
remains
unclear.
This
study
aims
to
investigate
association
older
adults
Guizhou,
southwestern
China.
Methods
The
data
were
obtained
from
Cohort
Study
of
Health
Status
Guizhou
Rural
Older
Adults
(SHGROC).
A
multi-stage
cluster
sampling
method
was
employed
select
1,088
aged
≥
60
years
Province
for
questionnaire
surveys,
physical
examinations,
biological
sample
collection.
Cognitive
function
participants
assessed
using
Mini-Mental
State
Examination
(MMSE).
Bilateral
measured
simultaneously
an
automated
device,
calculated.
Multivariable
linear
logistic
regression
models
used
examine
impairment.
Results
overall
prevalence
27.85%,
it
more
common
10
mmHg
(
P
<
0.05).
analysis
revealed
systolic
(IASBPD)
independently
lower
MMSE
scores
(β
=
−1.113;
95%
CI
:
−2.120,
−0.106;
0.030)
a
higher
risk
OR
1.902;
1.189,
3.040;
0.007).
Additionally,
dose-response
observed
IASBPD
impairment,
positive
correlation.
Further
subgroup
indicated
modified
by
sex,
smoking,
regular
exercise
interaction
Conclusion
is
increased
Chinese
adults.
suggested
may
provide
reference
early
identification
at
Язык: Английский
Introduction to Focused Update Vascular Cognitive Impairment and Dementia: Better Diagnosis, More Avenues for Prevention
Stroke,
Год журнала:
2024,
Номер
55(4), С. 788 - 790
Опубликована: Март 25, 2024
Язык: Английский
Effects of exercise on patients with vascular cognitive impairment based on ACSM recommendations: a systematic review of randomized controlled trials
Journal of Neurology,
Год журнала:
2024,
Номер
272(1)
Опубликована: Дек. 12, 2024
Язык: Английский
Onset of α5GABA-A Receptor Dependent Hippocampal Trisynaptic Circuit Dysfunction Is Associated Increased Age and Blood Pressure
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 25, 2024
ABSTRACT
Hypertension
onset
with
aging
is
of
widespread
clinical
significance,
predominantly
in
males,
yet
the
neural
circuitry
underpinnings
for
hypertension
associated
memory
dysfunction
remains
unknown.
Sprague
Dawley
(SD)
male
but
not
female
rats
develop
age
dependent
increases
mean
arterial
blood
pressure
(MAP)
by
16
months
age.
We
sought
to
interrogate
functional
integrity
hippocampal
trisynaptic
circuit
(HTC),
which
known
participate
memory,
determine
whether
age-associated
MAP
contributes
that
may
lead
mild-cognitive
impairment
(MCR).
Ripples,
and
specifically
sharp-wave
ripple
oscillations,
play
a
role
replay
consolidation
during
awake
immobility
among
other
behaviors.
These
synchronous
high
frequency
local
field
potentials
(LFPs)
band
(140
200
Hz)
serve
as
an
HTC
level
surrogate
marker
function
rodents,
non-human
primates,
humans.
Thus,
we
asked
increased
might
alter
dynamics.
Recognizing
each
patient
responds
unique
way
used
within
subject
design
wherein
animal
served
its
own
control
investigative
model.
surgically
implanted
density
silicon
probe
electrodes
CA1
young
aged
SD
males
nootropic
drug,
α5IA,
negative
allosteric
modulator
α5
subunit
containing
type-A
GABA
receptors,
could
detect
aberrant
modulation
ripples
subject.
Here
report
acute
oral
administration
α5IA
selectively
modulated
amplitude,
duration
or
epochs
immobility.
The
response
peak
amplitude
substantially
diminished
when
chronic
exceeds
160
mmHg,
corresponding
significant
hypertension.
results
are
consistent
model
dysfunctional
GABA-A
receptor
frequency,
potential
precision
biomarker
dysfunction.
Summary
Age-related
neurogenic
disrupts
involved
consolidation.
Язык: Английский
Non-Pharmacological Exercise Randomized Controlled Trials in Alzheimer’s Disease
Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
unknown, С. 1 - 8
Опубликована: Сен. 20, 2024
This
narrative
review
aimed
to
summarize
evidence
on
responses
exercise
in
pre-clinical
Alzheimer’s
disease
(AD)
and
how
long-term
programs
work
improve
neuropsychiatric
symptoms
cognitive
performance.
We
conducted
a
of
the
body
research
benefits
improving
performance
reducing
scores
patients
with
AD.
Long-term
therapy
appears
blood
flow,
increase
hippocampal
volume,
promote
neurogenesis
Higher
levels
physical
activity
are
associated
lower
chance
developing
disease,
most
prospective
studies
have
shown
that
inactivity
is
one
prevalent
modifiable
risk
factors
for
development
Exercise
be
beneficial
function,
symptom
has
been
fewer
side
effects,
such
as
non-pharmacological
effects
better
adherence
than
medication.
In
this
review,
experts
provided
snapshot
authoritative
summary
AD
based
best
synthesis
efforts,
identified
main
knowledge
gaps
relevant
barriers,
directions
future
research.
Furthermore,
randomized
trial
designs
practical
details
recommendations
researchers
working
area,
underscoring
importance
topics.
Язык: Английский
Exercise to prevent stroke and dementia—World Stroke Day 2024
International Journal of Stroke,
Год журнала:
2024,
Номер
19(9), С. 960 - 961
Опубликована: Окт. 1, 2024
Язык: Английский
Activation of endogenous mechanisms of sanogenesis in cognitive impairment in cerebral small vessel disease
S S Korsakov Journal of Neurology and Psychiatry,
Год журнала:
2024,
Номер
124(12), С. 7 - 7
Опубликована: Янв. 1, 2024
Cerebrovascular
diseases
themselves
are
the
second
most
common
cause
of
cognitive
impairment
(dementia).
In
addition,
cerebral
small
vessel
disease
(CSVD)
makes
a
significant
contribution
to
clinical
picture
neurodegenerative
diseases.
Since
there
currently
no
pharmacological
treatments
for
CSVD,
promising
method
is
activation
endogenous
mechanisms
sanogenesis.
The
article
provides
an
overview
studies
that
assess
effect
physical
exercise
on
and
MRI
CSVD.
It
has
been
established
sanogenesis
during
include
control
vascular
risk
factors,
improvement
endothelial
function
regulation
exerkine
secretion.
effectiveness
depends
type
(aerobic
or
resistance
training)
gender
person.
Resistance
training
higher
therapeutic
potential.
Understanding
these
aspects
will
help
improve
program
achieve
maximum
benefit
in
patients
with
Язык: Английский
Social Determinants of Health and Functional Brain Connectivity Predict Long-Term Physical Activity Adherence in Older Adults After a New Cardiovascular Diagnosis
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Physical
activity
is
essential
for
preventing
cognitive
decline,
stroke
and
dementia
in
older
adults.
A
new
cardiovascular
diagnosis
offers
a
critical
window
positive
lifestyle
changes.
However,
sustaining
physical
behavior
change
remains
challenging
the
underlying
mechanisms
are
poorly
understood.
To
identify
neural,
behavioral
contextual
predictors
of
successful
longer-term
after
diagnosis,
we
used
support
vector
machine
learning
to
predict
changes
moderate-to-vigorous
over
four
years
295
cognitively
unimpaired
adults
from
UK
Biobank,
testing
three
models
that
incorporated
baseline:
(i)
demographic,
cognitive,
factors,
(ii)
baseline
resting-state
functional
connectivity
alone,
(iii)
combined
multimodal
features
across
all
predictors.
The
multi-modal
model
had
highest
predictive
power
(r=0.28,
p=0.001).
Key
included
greenspace
access,
social
support,
retirement
status,
executive
function,
between-network
within
default
mode,
frontoparietal
control
salience/ventral
attention
networks.
These
findings
underscore
importance
structural
determinants
health
uncover
neural
may
modifications.
In
addition
furthering
our
understanding
change,
these
help
guide
design
interventions
policy
with
ultimate
goal
disease
burden
late-life
decline.
Язык: Английский