Journal of Medical Microbiology,
Год журнала:
2025,
Номер
74(3)
Опубликована: Март 12, 2025
Introduction.
Eye
diseases
are
widespread
all
over
the
world
and,
if
left
untreated,
can
lead
to
blindness.
Hypothesis.
The
use
of
0.05%
cyclosporine
A
(CsA)
solution
for
treatment
dry
eye
causes
a
decrease
in
discomfort
and
pain
improves
objective
measures
such
as
tear
film
breakdown
time,
Schirmer
test
results
Oxford
scale
scores
due
its
anti-inflammatory
immunomodulatory
properties
that
contribute
improved
stability
production.
Aim.
This
study
aimed
investigate
impact
CsA
on
progression
ocular
surface
diseases.
Methodology.
An
experiment
was
conducted
basis
FOCUS
ophthalmology
centre,
Kazakhstan.
group
100
individuals
diagnosed
with
mild
severe
illness
were
administered
drops
part
protocol.
Results.
positive
effect
is
explained
by
effects
CsA.
showed
disease
led
pain,
well
an
improvement
measures,
including
scores.
visual
analogue
significant
reduction
symptoms,
from
6.8
points
at
baseline
3.7
day
60.
In
total,
20%
patients
reported
moderate
side
effects,
during
instillation
redness
surface.
Conclusion.
It
concluded
these
reduced
patient
condition
enhanced
indicators
scale,
breakup
corneal
conjunctival
staining.
differs
previous
ones
it
focuses
efficacy
also
examines
spectrum
frequency
which
not
sufficiently
covered
studies.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(23)
Опубликована: Май 13, 2023
Abstract
The
increase
in
antibiotic
resistance
promotes
the
situation
of
developing
new
antibiotics
at
forefront,
while
development
non‐antibiotic
pharmaceuticals
is
equally
significant.
In
post‐antibiotic
era,
nanomaterials
with
high
antibacterial
efficiency
and
no
drug
make
them
attractive
candidates
for
materials.
Carbon
dots
(CDs),
as
a
kind
carbon‐based
zero‐dimensional
nanomaterial,
are
attracting
much
attention
their
multifunctional
properties.
abundant
surface
states,
tunable
photoexcited
excellent
photo‐electron
transfer
properties
sterilization
CDs
feasible
gradually
emerging
field.
This
review
provides
comprehensive
insights
into
recent
topics
include
mechanisms,
design,
optimization
processes,
potential
practical
applications
also
highlighted,
such
treatment
bacterial
infections,
against
biofilms,
surfaces,
food
preservation,
bacteria
imaging
detection.
Meanwhile,
challenges
outlook
field
discussed
proposed.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Апрель 8, 2024
Abstract
Dry
eye
disease
(DED)
is
associated
with
ocular
hyperosmolarity
and
inflammation.
The
marketed
topical
drops
for
DED
treatment
often
lack
bioavailability
precorneal
residence
time.
In
this
study,
we
investigated
catechol-functionalized
polyzwitterion
p(MPC-
co
-DMA),
composed
of
2-methacryloyloxyethyl
phosphorylcholine
(MPC)
dopamine
methacrylamide
(DMA)
monomers,
as
potential
nanotherapeutics
DED.
copolymers
were
synthesized
via
random
free-radical
copolymerization,
producing
different
proportions
catecholic
functionalization.
All
as-prepared
polymer
compositions
displayed
good
biocompatibility.
At
a
feeding
ratio
1:1,
p(MPC
1
-
-DMA
)
can
facilitate
robust
mucoadhesion
Michael
addition
and/or
Schiff
base
reaction,
thus
prolonging
time
after
4
days
instillation.
hydration
lubrication
MPC
radical-scavenging
DMA
endow
the
nano-agent
to
ease
tear-film
corneal
A
single
dose
(1
mg/mL)
post-instillation
protect
cornea
against
reactive
oxygen
species,
inhibiting
cell
apoptosis
over-expression
pro-inflammatory
factors
(IL-6
TNF-α).
clinical
assessment,
DED-induced
rabbit
eyes
receiving
could
increase
lacrimal
fluid
secretion
by
5-fold
higher
than
cyclosporine
A.
enhanced
lubricity,
mucoadhesion,
anti-oxidation/anti-inflammation
properties
has
shown
high
promise
bioactive
drop
formulation
treating
Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 422 - 422
Опубликована: Март 29, 2024
Dry
eye
disease
(DED)
is
a
multifactorial
condition
affecting
the
ocular
surface.
It
characterized
by
loss
of
tear
film
homeostasis
and
accompanied
symptoms
that
may
potentially
result
in
damage
to
surface
even
vision
loss.
Unmodifiable
risk
factors
for
DED
mainly
include
aging,
hormonal
changes,
lifestyle
issues
such
as
reduced
sleep
duration,
increased
screen
exposure,
smoking,
ethanol
consumption.
As
its
prevalence
continues
rise,
has
garnered
considerable
attention,
prompting
exploration
potential
new
therapeutic
targets.
Recent
studies
have
found
when
production
ROS
exceeds
capacity
antioxidant
defense
system
on
surface,
oxidative
stress
ensues,
leading
cellular
apoptosis
further
damage.
These
events
can
exacerbate
inflammation
responses,
increasing
levels
promoting
vicious
cycle
DED.
Therefore,
given
central
role
reactive
oxygen
species
DED,
strategies
involving
antioxidants
emerged
novel
approach
treatment.
This
review
aims
enhance
our
understanding
intricate
relationship
between
thereby
providing
directions
explore
innovative
approaches
this
complex
disorder.
Nanotechnology
has
accelerated
the
development
of
pharmaceutical
and
medical
technology
fields,
nanogels
for
ocular
applications
have
proven
to
be
a
promising
therapeutic
strategy.
Traditional
preparations
are
restricted
by
anatomical
physiological
barriers
eye,
resulting
in
short
retention
time
low
drug
bioavailability,
which
is
significant
challenge
physicians,
patients,
pharmacists.
Nanogels,
however,
ability
encapsulate
drugs
within
three-dimensional
crosslinked
polymeric
networks
and,
through
specific
structural
designs
distinct
methods
preparation,
achieve
controlled
sustained
delivery
loaded
drugs,
increasing
patient
compliance
efficiency.
In
addition,
higher
drug-loading
capacity
biocompatibility
than
other
nanocarriers.
this
review,
main
focus
on
diseases,
whose
stimuli-responsive
behaviors
briefly
described.
The
current
comprehension
topical
will
improved
focusing
advances
typical
including
glaucoma,
cataracts,
dry
eye
syndrome,
bacterial
keratitis,
as
well
related
drug-loaded
contact
lenses
natural
active
substances.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 8, 2024
Abstract
Efficiently
removing
excess
reactive
oxygen
species
(ROS)
generated
by
various
factors
on
the
ocular
surface
is
a
promising
strategy
for
preventing
development
of
dry
eye
disease
(DED).
The
currently
available
drops
DED
treatment
are
palliative,
short-lived
and
frequently
administered
due
to
short
precorneal
residence
time.
Here,
we
developed
nanozyme-based
exploiting
borate-mediated
dynamic
covalent
complexation
between
n-FeZIF-8
nanozymes
(n-Z(Fe))
poly(vinyl
alcohol)
(PVA)
overcome
these
problems.
resultant
formulation
(PBnZ),
which
has
dual-ROS
scavenging
abilities
prolonged
corneal
retention
can
effectively
reduce
oxidative
stress,
thereby
providing
an
excellent
preventive
effect
alleviate
DED.
In
vitro
in
vivo
experiments
revealed
that
PBnZ
could
eliminate
ROS
through
both
its
multienzyme-like
activity
ROS-scavenging
borate
bonds.
positively
charged
displayed
longer
time
physical
adhesion
bonds
phenyboronic
acid
PVA
or
o-diol
with
mucin.
results
showed
These
dual-function
provide
insights
into
novel
strategies
other
ROS-mediated
inflammatory
diseases
rationale
application
nanomaterials
clinical
settings.
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