CBX7 promotes choroidal neovascularization by activating the HIF-1α/VEGF pathway in choroidal vascular endothelial cells

Experimental Eye Research, Год журнала: 2024, Номер 247, С. 110057 - 110057

Опубликована: Авг. 23, 2024

Язык: Английский

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The effect of intestinal flora metabolites on macrophage polarization

Heliyon, Год журнала: 2024, Номер 10(15), С. e35755 - e35755

Опубликована: Авг. 1, 2024

Intestinal flora metabolites played a crucial role in immunomodulation by influencing host immune responses through various pathways. Macrophages, as type of innate cell, were essential chemotaxis, phagocytosis, inflammatory responses, and microbial elimination. Different macrophage phenotypes had distinct biological functions, regulated diverse factors mechanisms. Advances intestinal sequencing metabolomics have enhanced understanding how affect functions. These varying effects on polarization different mechanisms influence. This study summarized the impact gut microbiota phenotype function, along with underlying associated produced flora.

Язык: Английский

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TLR4/TRIF/Caspase-8/Caspase-1 Pathway in Choroidal Endothelial Cells Promotes Choroidal Neovascularization

Current Eye Research, Год журнала: 2024, Номер unknown, С. 1 - 10

Опубликована: Окт. 11, 2024

Purpose The purpose of this study was to investigate the role and mechanism caspase-8 in development choroidal neovascularization induced by age-related macular degeneration, with aim identifying a potential therapeutic target for neovascular degeneration.

Язык: Английский

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Choroidal macrophages in homeostasis, aging and age-related macular degeneration.

Experimental Eye Research, Год журнала: 2024, Номер 250, С. 110159 - 110159

Опубликована: Ноя. 20, 2024

Язык: Английский

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