The effect of intestinal flora metabolites on macrophage polarization

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35755 - e35755

Published: Aug. 1, 2024

Intestinal flora metabolites played a crucial role in immunomodulation by influencing host immune responses through various pathways. Macrophages, as type of innate cell, were essential chemotaxis, phagocytosis, inflammatory responses, and microbial elimination. Different macrophage phenotypes had distinct biological functions, regulated diverse factors mechanisms. Advances intestinal sequencing metabolomics have enhanced understanding how affect functions. These varying effects on polarization different mechanisms influence. This study summarized the impact gut microbiota phenotype function, along with underlying associated produced flora.

Language: Английский

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CBX7 promotes choroidal neovascularization by activating the HIF-1α/VEGF pathway in choroidal vascular endothelial cells

Experimental Eye Research, Journal Year: 2024, Volume and Issue: 247, P. 110057 - 110057

Published: Aug. 23, 2024

Language: Английский

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TLR4/TRIF/Caspase-8/Caspase-1 Pathway in Choroidal Endothelial Cells Promotes Choroidal Neovascularization

Current Eye Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Oct. 11, 2024

Purpose The purpose of this study was to investigate the role and mechanism caspase-8 in development choroidal neovascularization induced by age-related macular degeneration, with aim identifying a potential therapeutic target for neovascular degeneration.

Language: Английский

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Choroidal macrophages in homeostasis, aging and age-related macular degeneration.

Experimental Eye Research, Journal Year: 2024, Volume and Issue: 250, P. 110159 - 110159

Published: Nov. 20, 2024

Language: Английский

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