Multiple-pulse damage thresholds of retinal explants in the ns-time regime DOI Creative Commons

Scarlett Lipp,

Sebastian Kotzur,

Philipp Elmlinger

и другие.

Biomedical Optics Express, Год журнала: 2020, Номер 11(12), С. 7299 - 7299

Опубликована: Ноя. 13, 2020

The data situation of laser-induced damage measurements after multiple-pulse irradiation in the ns-time regime is limited. Since laser safety standard based on experiments, it crucial to determine thresholds. For a better understanding underlying mechanism repetitive irradiation, we generate thresholds for pulse sequences up N = 20 000 with 1.8 ns-pulses using square-core fiber and pulsed Nd:YAG laser. Porcine retinal pigment epithelial layers were used as tissue samples, irradiated six evaluated by fluorescence microscopy. decreased from 31.16 µJ 1 11.56 000. reduction indicates photo-chemical mechanisms reaching critical energy dose.

Язык: Английский

Exploring Retinal Conditions Through Blue Light Reflectance Imaging DOI
Ricardo Luz Leitão Guerra,

Cezar Luz Leitão Guerra,

Mariana Gouveia Bastos Meirelles

и другие.

Progress in Retinal and Eye Research, Год журнала: 2025, Номер 105, С. 101326 - 101326

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

0

Adaptive optics two-photon excited fluorescence lifetime imaging ophthalmoscopy of photoreceptors and retinal pigment epithelium in the living non-human primate eye DOI Creative Commons
Sarah Walters,

James A. Feeks,

Khang T. Huynh

и другие.

Biomedical Optics Express, Год журнала: 2021, Номер 13(1), С. 389 - 389

Опубликована: Дек. 6, 2021

Fluorescence lifetime imaging has demonstrated promise as a quantitative measure of cell health. Adaptive optics two-photon excited fluorescence (TPEF) ophthalmoscopy enables excitation intrinsic retinal fluorophores involved in cellular metabolism and the visual cycle, providing

Язык: Английский

Процитировано

14

Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration DOI Creative Commons
Harshini Chakravarthy,

Vasil Georgyev,

Cole Wagen

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Дек. 17, 2024

Sunlight exposure is recognized as a risk factor for the development of age-related macular degeneration (AMD), common neurodegenerative retinal disease in elderly. Specifically, blue light wavelengths within sunlight can negatively impact physiology light-sensitive cells, including pigmented epithelium (RPE) and photoreceptors. This review explores light-induced degeneration, emphasizing structural functional impairments RPE. The initial section provides brief overview light's effects on photoreceptors, followed by comprehensive analysis its detrimental

Язык: Английский

Процитировано

1

In Vivo Functional Imaging of Retinal Neurons Using Red and Green Fluorescent Calcium Indicators DOI
Soon Keen Cheong, Wenjun Xiong,

Jennifer M. Strazzeri

и другие.

Advances in experimental medicine and biology, Год журнала: 2018, Номер unknown, С. 135 - 144

Опубликована: Янв. 1, 2018

Язык: Английский

Процитировано

2

Multiple-pulse damage thresholds of retinal explants in the ns-time regime DOI Creative Commons

Scarlett Lipp,

Sebastian Kotzur,

Philipp Elmlinger

и другие.

Biomedical Optics Express, Год журнала: 2020, Номер 11(12), С. 7299 - 7299

Опубликована: Ноя. 13, 2020

The data situation of laser-induced damage measurements after multiple-pulse irradiation in the ns-time regime is limited. Since laser safety standard based on experiments, it crucial to determine thresholds. For a better understanding underlying mechanism repetitive irradiation, we generate thresholds for pulse sequences up N = 20 000 with 1.8 ns-pulses using square-core fiber and pulsed Nd:YAG laser. Porcine retinal pigment epithelial layers were used as tissue samples, irradiated six evaluated by fluorescence microscopy. decreased from 31.16 µJ 1 11.56 000. reduction indicates photo-chemical mechanisms reaching critical energy dose.

Язык: Английский

Процитировано

1