Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 8, 2024
The
infant
gut
microbiota
undergoes
significant
changes
during
early
life,
which
are
essential
for
immune
system
maturation,
nutrient
absorption,
and
metabolic
programming.
Among
the
various
microbial
metabolites,
short-chain
fatty
acids
(SCFAs),
primarily
acetate,
propionate,
butyrate,
produced
through
fermentation
of
dietary
fibers
by
bacteria,
have
emerged
as
critical
modulators
host-microbiota
interactions.
SCFAs
serve
energy
sources
colonic
cells
play
pivotal
roles
in
regulating
responses,
maintaining
barrier
integrity,
influencing
systemic
pathways.
Recent
research
highlights
potential
neuroprotective
effects
pediatric
populations.
Disruptions
composition
SCFA
production
increasingly
associated
with
a
range
health
issues,
including
obesity,
allergic
disorders,
inflammatory
bowel
disease
(IBD),
neurodevelopmental
disorders.
This
review
synthesizes
current
knowledge
on
role
microbiota-derived
health,
emphasizing
their
contributions
from
development
to
neuroprotection.
It
also
underscores
need
further
unravel
precise
mechanisms
influence
develop
targeted
interventions
that
leverage
therapeutic
benefits.
Cell,
Год журнала:
2021,
Номер
184(13), С. 3394 - 3409.e20
Опубликована: Июнь 1, 2021
The
human
fetal
immune
system
begins
to
develop
early
during
gestation;
however,
factors
responsible
for
immune-priming
remain
elusive.
We
explored
potential
exposure
microbial
agents
in
utero
and
their
contribution
toward
activation
of
memory
T
cells
tissues.
profiled
microbes
across
organs
using
16S
rRNA
gene
sequencing
detected
low
but
consistent
signal
gut,
skin,
placenta,
lungs
the
2nd
trimester
gestation.
identified
several
live
bacterial
strains
including
Staphylococcus
Lactobacillus
tissues,
which
induced
vitro
mesenteric
lymph
node,
supporting
role
immune-priming.
Finally,
SEM
RNA-ISH,
we
visualized
discrete
localization
bacteria-like
structures
eubacterial-RNA
within
14th
weeks
gut
lumen.
These
findings
indicate
selective
presence
gestation
have
broader
implications
establishment
competency
priming
before
birth.
Biomolecules,
Год журнала:
2020,
Номер
10(4), С. 593 - 593
Опубликована: Апрель 11, 2020
Current
knowledge
suggests
that
the
uterus
harbours
its
own
microbiota,
where
microbes
could
influence
uterine
functions
in
health
and
disease;
however,
core
microbial
composition
host-microbial
relationships
remain
to
be
fully
elucidated.
Different
studies
are
indicating,
based
on
next-generation
sequencing
techniques,
dysbiosis
associated
with
several
gynaecological
disorders,
such
as
endometriosis,
chronic
endometritis,
dysfunctional
menstrual
bleeding,
endometrial
cancer,
infertility.
Treatments
using
antibiotics
probiotics
and/or
prebiotics
for
being
applied.
Nevertheless
there
is
no
unified
protocol
assessing
optimal
treatment
established
dysbiosis.
With
this
review
we
outline
(mostly
bacteria)
identified
microbiome
studies,
current
treatments
offered
bacterial
clinical
setting,
future
possibilities
pro-
transplants
modifying
composition.
Environmental Science & Technology,
Год журнала:
2022,
Номер
57(46), С. 17774 - 17785
Опубликована: Окт. 21, 2022
Pregnancy
and
infancy
are
vulnerable
times
for
detrimental
environmental
exposures.
However,
the
exposure
situation
of
microplastics
(MPs)
mother-infant
pairs
adverse
health
effect
MPs
largely
unknown.
Therefore,
we
explored
MP
in
placentas
meconium
samples,
potential
correlation
with
microbiota
meconium.
A
total
18
were
effectively
recruited
from
Shanghai,
China.
The
study
required
pregnant
women
to
provide
samples.
An
Agilent
8700
laser
infrared
imaging
spectrometer
(LDIR)
was
applied
identify
MPs.
Microbiota
detection
identified
by
16S
rRNA
sequencing.
Sixteen
types
found
all
matrices,
polyamide
(PA)
polyurethane
(PU)
major
identified.
detected
samples
a
size
20-50
μm
more
than
76.46%.
At
phylum
level,
both
placenta
mainly
composed
Proteobacteria,
Bacteroidota,
Firmicutes.
We
also
some
significant
differences
between
β-diversity
gut
composition.
Additionally,
polystyrene
inversely
related
Chao
index
microbiota.
Polyethylene
consistently
correlated
several
genera
MPs,
PA,
PU
impacted
In
conclusion,
ubiquitous
indicating
wide
infants.
Moreover,
our
findings
may
support
link
high
concentration
there
associations
particle
50-100
Frontiers in Cell and Developmental Biology,
Год журнала:
2022,
Номер
10
Опубликована: Апрель 14, 2022
The
gut
microbiome
has
a
tremendous
influence
on
human
physiology,
including
the
nervous
system.
During
fetal
development,
initial
colonization
of
coincides
with
development
system
in
timely,
coordinated
manner.
Emerging
studies
suggest
an
active
involvement
and
its
metabolic
by-products
regulating
early
brain
development.
However,
any
disruption
during
this
developmental
process
can
negatively
impact
functionality,
leading
to
range
neurodevelopment
neuropsychiatric
disorders
(NPD).
In
review,
we
summarize
recent
evidence
as
how
association
major
neurodevelopmental
psychiatric
such
autism
spectrum
disorders,
attention-deficit
hyperactivity
disorder,
schizophrenia.
Further,
discuss
alterations
also
play
role
inducing
drug
resistance
affected
individuals.
We
propose
model
that
establishes
direct
link
dysbiosis
exacerbated
inflammatory
state,
functional
deficits
associated
NPD.
Based
existing
research,
framework
whereby
diet
intervention
boost
mental
wellness
subjects
call
for
further
research
better
understanding
mechanisms
govern
gut-brain
axis
may
lead
novel
approaches
study
pathophysiology
treatment
disorders.
The
microbiome
has
been
proven
to
be
associated
with
many
diseases
and
used
as
a
biomarker
target
in
disease
prevention
intervention.
Currently,
the
vital
role
of
pregnant
women
newborns
is
increasingly
emphasised.
In
this
review,
we
discuss
interplay
corresponding
immune
mechanism
between
mothers
their
offspring
during
perinatal
period.
We
aim
present
comprehensive
picture
microbial
transmission
potential
imprinting
before
after
delivery.
addition,
possibility
utero
colonisation
pregnancy,
which
highly
debated
recent
studies,
highlight
importance
infant
development
first
3
years
life.
This
holistic
view
infants
will
refine
our
current
understanding
pregnancy
complications
well
early
life
greatly
facilitate
microbiome-based
prenatal
diagnosis
treatment
mother-infant-related
diseases.
Nutrients,
Год журнала:
2024,
Номер
16(10), С. 1420 - 1420
Опубликована: Май 8, 2024
One
of
the
most
important
bioactive
components
breast
milk
are
free
oligosaccharides,
which
a
source
energy
for
commensal
intestinal
microorganisms,
stimulating
growth
Bifidobacterium,
Lactobacillus,
and
Bacteroides
in
child’s
digestive
tract.
There
is
some
evidence
that
maternal,
perinatal,
environmental-cultural
factors
influence
modulation
microbiome.
This
review
summarizes
research
has
examined
composition
microbiome
may
it.
The
manuscript
highlights
potential
importance
future
development
health
children.
origin
bacteria
thought
to
include
mother’s
tract
(entero-mammary
tract),
bacterial
exposure
during
breastfeeding,
retrograde
flow
from
infant’s
mouth
woman’s
ducts.
Unfortunately,
despite
increasingly
more
precise
methods
assessing
microorganisms
human
milk,
topic
still
quite
limited
requires
scientific
takes
into
account
various
conditions.
Current Opinion in Microbiology,
Год журнала:
2020,
Номер
56, С. 30 - 37
Опубликована: Июль 4, 2020
Early
life
is
a
critical
time
window
for
the
neonatal
gut
to
be
progressively
populated
with
different
bacterial
species
that
collectively
promote
maturation.
A
fully
developed
and
healthy
microbiome
in
neonates
an
important
driver
development
of
other
aspects
health.
Unlike
relatively
stable
adults,
developing
exhibits
higher
plasticity
adaptability.
This
also
underscores
unique
opportunity
intervention
or
preventive
measures
improve
long-term
health
through
modulations
early
life.
Better
understanding
—
how
it
arises
impacts
immune
cell
will
help
us
appreciate
underpinnings
immune-related
diseases.
Here,
we
examine
recent
findings
on
discuss
their
implications
this
maturation
system
immunity
against
infections
