Seminars in Cell and Developmental Biology, Год журнала: 2021, Номер 124, С. 48 - 62
Опубликована: Апрель 29, 2021
Язык: Английский
Nature Reviews Rheumatology, Год журнала: 2021, Номер 17(6), С. 333 - 348
Опубликована: Апрель 28, 2021
Язык: Английский
Процитировано
182
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Июль 22, 2022
Background Autoimmune diseases (AIDs) are a class of chronic disabling characterized by inflammation and damage to muscles, joints, bones, internal organs. Recent studies have shown that much progress has been made in the research exosomes AIDs. However, there is no bibliometric analysis this field. This study aims provide comprehensive overview knowledge structure hotspots AIDs through bibliometrics. Method Publications related from 2002 2021 were searched on web science core collection (WoSCC) database. VOSviewers, CiteSpace R package “bibliometrix” used conduct analysis. Results 312 articles 48 countries led China United States included. The number publications increasing year year. Central South University, Sun Yat Sen Tianjin Medical University Pennsylvania main institutions. Frontiers immunology most popular journal field, Journal Immunology co-cited journal. These come 473 authors among which Ilias Alevizos, Qianjin Lu, Wei Wei, Jim Xiang Ming Zhao had published papers Clotilde Théry was often. Studying mechanism endogenous occurrence development therapeutic strategy exogenous topics “Mesenchymal stem cells”, “microRNA”, “biomarkers”, “immunomodulation”, “therapy” primary keywords emerging hotspots. Conclusion first comprehensively summarizes trends developments information identifies recent frontiers hot directions, will reference for scholars studying exosomes.
Язык: Английский
Процитировано
112
Journal of Neuroimmunology, Год журнала: 2021, Номер 358, С. 577640 - 577640
Опубликована: Июнь 24, 2021
Язык: Английский
Процитировано
85
Physiological Reviews, Год журнала: 2021, Номер 102(2), С. 815 - 857
Опубликована: Окт. 26, 2021
Adenylyl cyclases (ACs) catalyze the conversion of ATP to ubiquitous second messenger cAMP. Mammals possess nine isoforms transmembrane ACs, dubbed AC1-9, that serve as major effector enzymes G protein-coupled receptors (GPCRs). The ACs display varying expression patterns across tissues, giving potential for them have a wide array physiological roles. Cells express multiple AC isoforms, implying redundant functions. Furthermore, all are activated by Gα
Язык: Английский
Процитировано
83
Autoimmunity Reviews, Год журнала: 2022, Номер 22(3), С. 103260 - 103260
Опубликована: Дек. 21, 2022
Язык: Английский
Процитировано
59
Frontiers in Oncology, Год журнала: 2022, Номер 12
Опубликована: Март 14, 2022
Exosomes are important mediators of intercellular communication and participate in complex biological processes by transferring a variety bioactive molecules between cells. Epithelial–mesenchymal transition (EMT) is process which the cell phenotype changes from epithelioid to mesenchymal-like. EMT also an for cancer cells they acquire invasive metastatic capabilities, aggravates degree tumor malignancy. Numerous studies have demonstrated that exosomes encapsulate various components, such as microRNAs proteins, transfer information or microenvironment, thereby regulating process. can be used diagnosis treatment drug delivery platform. Thus, therapeutic tool control occurrence affect progression. In this review, we summarize latest research advancements regulation contents exosomes. Furthermore, discuss potential challenges using treatment.
Язык: Английский
Процитировано
40
Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11
Опубликована: Янв. 24, 2023
Exosomes are natural extracellular vesicles with a diameter of 30–150 nm, which exist in biological fluids and contain biomolecules related to the parent cell, such as proteins, nucleic acids, lipids, etc. It has wide range functions, participates regulation important physiological pathological activities body. can be used biomarker for early diagnosis ocular diseases, potential therapeutic target, targeted drug carrier, high clinical application. In this paper, we summarized genesis mechanism, research application progress exosomes, focused on engineering strategy advantages disadvantages common exosome preparation methods. Systematically combed role exosomes corneal glaucoma, retinal provide reference further understanding pathogenesis, diagnosis, treatment diseases. Finally, opportunities challenges precision medicine. The extension field ophthalmology will help advance current diagnostic Tiny have huge potential.
Язык: Английский
Процитировано
33
Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
1
The Ocular Surface, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
International Journal of Oral Science, Год журнала: 2025, Номер 17(1)
Опубликована: Фев. 3, 2025
Abstract The oral and maxillofacial region is a highly complex area composed of multiple tissue types bears various critical functions the human body. Diseases in this pose significant diagnostic management challenges; therefore, exploring new strategies for early diagnosis, targeted treatment, reconstruction key to improving patient prognosis quality life. Extracellular vesicles are group heterogeneous lipid-bilayer membrane structures secreted by most cell types, including exosomes, microvesicles, apoptotic bodies. Present body fluids tissues, they act as messengers via transfer nucleic acids, proteins, metabolites recipient cells. To date, studies have revealed different roles extracellular physiological or pathological processes, well applications disease prognosis, treatment. importance specificity dental tissues indicate that derived from promising further research. This paper reviews published data on cells, fluids, regions, summarizes latest advances extensive sources, concludes with focus current research progress application prospects engineered exosomes science.
Язык: Английский
Процитировано
1