MicroRNAs in shaping the resolution phase of inflammation DOI Creative Commons
Raza Ali Naqvi,

Meenal Gupta,

Anne George

et al.

Seminars in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 124, P. 48 - 62

Published: April 29, 2021

Language: Английский

Epithelial–immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis DOI Open Access
Gwenny M. Verstappen, Sarah Pringle, Hendrika Bootsma

et al.

Nature Reviews Rheumatology, Journal Year: 2021, Volume and Issue: 17(6), P. 333 - 348

Published: April 28, 2021

Language: Английский

Citations

182
Knowledge Mapping of Exosomes in Autoimmune Diseases: A Bibliometric Analysis (2002–2021) DOI Creative Commons
Fengping Wu, Jinfang Gao, Jie Kang

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 22, 2022

Background Autoimmune diseases (AIDs) are a class of chronic disabling characterized by inflammation and damage to muscles, joints, bones, internal organs. Recent studies have shown that much progress has been made in the research exosomes AIDs. However, there is no bibliometric analysis this field. This study aims provide comprehensive overview knowledge structure hotspots AIDs through bibliometrics. Method Publications related from 2002 2021 were searched on web science core collection (WoSCC) database. VOSviewers, CiteSpace R package “bibliometrix” used conduct analysis. Results 312 articles 48 countries led China United States included. The number publications increasing year year. Central South University, Sun Yat Sen Tianjin Medical University Pennsylvania main institutions. Frontiers immunology most popular journal field, Journal Immunology co-cited journal. These come 473 authors among which Ilias Alevizos, Qianjin Lu, Wei Wei, Jim Xiang Ming Zhao had published papers Clotilde Théry was often. Studying mechanism endogenous occurrence development therapeutic strategy exogenous topics “Mesenchymal stem cells”, “microRNA”, “biomarkers”, “immunomodulation”, “therapy” primary keywords emerging hotspots. Conclusion first comprehensively summarizes trends developments information identifies recent frontiers hot directions, will reference for scholars studying exosomes.

Language: Английский

Citations

112
The pathogenic, therapeutic and diagnostic role of exosomal microRNA in the autoimmune diseases DOI
Rasoul Mirzaei, Farhad Zamani,

Marzieh Hajibaba

et al.

Journal of Neuroimmunology, Journal Year: 2021, Volume and Issue: 358, P. 577640 - 577640

Published: June 24, 2021

Language: Английский

Citations

85
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms DOI
Katrina F. Ostrom, Justin LaVigne, Tarsis F. Brust

et al.

Physiological Reviews, Journal Year: 2021, Volume and Issue: 102(2), P. 815 - 857

Published: Oct. 26, 2021

Adenylyl cyclases (ACs) catalyze the conversion of ATP to ubiquitous second messenger cAMP. Mammals possess nine isoforms transmembrane ACs, dubbed AC1-9, that serve as major effector enzymes G protein-coupled receptors (GPCRs). The ACs display varying expression patterns across tissues, giving potential for them have a wide array physiological roles. Cells express multiple AC isoforms, implying redundant functions. Furthermore, all are activated by Gα

Language: Английский

Citations

83
Exosomes as biomarkers and therapeutic delivery for autoimmune diseases: Opportunities and challenges DOI
Fang Yang, Jing Ni, Yun-Sheng Wang

et al.

Autoimmunity Reviews, Journal Year: 2022, Volume and Issue: 22(3), P. 103260 - 103260

Published: Dec. 21, 2022

Language: Английский

Citations

59
Exosomes Regulate the Epithelial–Mesenchymal Transition in Cancer DOI Creative Commons

Jingwen Jiang,

Jiayu Li,

Xiumei Zhou

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: March 14, 2022

Exosomes are important mediators of intercellular communication and participate in complex biological processes by transferring a variety bioactive molecules between cells. Epithelial–mesenchymal transition (EMT) is process which the cell phenotype changes from epithelioid to mesenchymal-like. EMT also an for cancer cells they acquire invasive metastatic capabilities, aggravates degree tumor malignancy. Numerous studies have demonstrated that exosomes encapsulate various components, such as microRNAs proteins, transfer information or microenvironment, thereby regulating process. can be used diagnosis treatment drug delivery platform. Thus, therapeutic tool control occurrence affect progression. In this review, we summarize latest research advancements regulation contents exosomes. Furthermore, discuss potential challenges using treatment.

Language: Английский

Citations

40
Research progress of exosomes in pathogenesis, diagnosis, and treatment of ocular diseases DOI Creative Commons

Xinting Feng,

Zhen Peng,

Lingyi Yuan

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Jan. 24, 2023

Exosomes are natural extracellular vesicles with a diameter of 30–150 nm, which exist in biological fluids and contain biomolecules related to the parent cell, such as proteins, nucleic acids, lipids, etc. It has wide range functions, participates regulation important physiological pathological activities body. can be used biomarker for early diagnosis ocular diseases, potential therapeutic target, targeted drug carrier, high clinical application. In this paper, we summarized genesis mechanism, research application progress exosomes, focused on engineering strategy advantages disadvantages common exosome preparation methods. Systematically combed role exosomes corneal glaucoma, retinal provide reference further understanding pathogenesis, diagnosis, treatment diseases. Finally, opportunities challenges precision medicine. The extension field ophthalmology will help advance current diagnostic Tiny have huge potential.

Language: Английский

Citations

33
Exosomes in Autoimmune Diseases: A Review of Mechanisms and Diagnostic Applications DOI

Lina Duan,

Wanying Lin, Yi Zhang

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Jan. 17, 2025

Language: Английский

Citations

1
Application of Stem Cell-Derived Exosomes in Anterior Segment Eye Diseases: A Comprehensive Update Review DOI
Masoud Khorrami‐Nejad, Hesam Hashemian,

Ali Majdi

et al.

The Ocular Surface, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Emerging roles of extracellular vesicles in oral and maxillofacial areas DOI Creative Commons
Qianting Wang, Jiayu Sun, Hongbing Jiang

et al.

International Journal of Oral Science, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 3, 2025

Abstract The oral and maxillofacial region is a highly complex area composed of multiple tissue types bears various critical functions the human body. Diseases in this pose significant diagnostic management challenges; therefore, exploring new strategies for early diagnosis, targeted treatment, reconstruction key to improving patient prognosis quality life. Extracellular vesicles are group heterogeneous lipid-bilayer membrane structures secreted by most cell types, including exosomes, microvesicles, apoptotic bodies. Present body fluids tissues, they act as messengers via transfer nucleic acids, proteins, metabolites recipient cells. To date, studies have revealed different roles extracellular physiological or pathological processes, well applications disease prognosis, treatment. importance specificity dental tissues indicate that derived from promising further research. This paper reviews published data on cells, fluids, regions, summarizes latest advances extensive sources, concludes with focus current research progress application prospects engineered exosomes science.

Language: Английский

Citations

1