Life Sciences, Год журнала: 2025, Номер 373, С. 123657 - 123657
Опубликована: Апрель 28, 2025
Язык: Английский
Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 24(9), С. 607 - 632
Опубликована: Май 24, 2023
Язык: Английский
Процитировано
111
SLEEP, Год журнала: 2023, Номер 46(5)
Опубликована: Фев. 17, 2023
Abstract The onset of melatonin secretion, the dim light (DLMO), is a tool for determining phase circadian timing system. Although small studies have investigated impacts age and methods calculating DLMO, there no DLMO reference range. In current study, saliva from 3579 participants 121 published plasma 818 healthy controls 31 (aged 3–73 years) were analyzed. subset 53 papers (1749 participants), individual Morningness Eveningness Questionaire (MEQ) scores obtained authors or mined publications range was constructed. Saliva earliest in children to 10 years latest around 20 thereafter advanced with by 30 min oldest participants. Melatonin assay calculation had little effect on determination DLMO. correlated (p < 0.001) MEQ score; lower associated later increased age, reflecting tendency toward morningness. An evaluation 14 clinically diagnosed patients living delayed sleep–wake disorder (mean ages revealed mean within albeit at late extreme. Peak levels 179 high degree variability groups, but only decline between 50 lowest after 70 years.
Язык: Английский
Процитировано
47
Journal of Biological Rhythms, Год журнала: 2021, Номер 36(6), С. 503 - 531
Опубликована: Сен. 22, 2021
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology and behavior, exemplified by cycles sleep/wake, hormone release, metabolism. The adaptive value is evident when internal body daily environmental mismatched, such as in the case shift work jet lag or even mistimed eating, all which associated with physiological disruption disease. Studies animal human models have also unraveled an important role functional circadian modulating cellular organismal responses to cues (ex., food intake, exercise), pathological insults (e.g. virus parasite infections), medical interventions medication). With growing knowledge molecular underlying pathophysiology, it becoming possible target for disease prevention treatment. In this review, we discuss recent advances research potential therapeutic applications take patient into account treating
Язык: Английский
Процитировано
90
Endocrinology, Год журнала: 2020, Номер 161(12)
Опубликована: Ноя. 3, 2020
Abstract Obesity and type 2 diabetes (T2D) have become a global health concern. The prevalence of obesity T2D is significantly higher in shift workers compared to people working regular hours. An accepted hypothesis that the increased risk for metabolic problems arises from aberrantly timed eating behavior, is, out synchrony with biological clock. clock part internal circadian timing system, which controls not only sleep/wake feeding/fasting cycle, but also many processes body, including our involved glucose homeostasis. Rodent studies shown phase endogenous results desynchronization between rhythms central peripheral systems different tissue clocks (eg, liver muscle clock). Glucose homeostasis complex process involves multiple organs. In healthiest situation, functional these organs are synchronized. We hypothesize metabolically active contributes alterations Here we summarize most recent information on due work shifted food intake patterns introduce concept phenotypic flexibility, validated test assess contribution each organ insulin resistance (IR) humans. propose this as way provide further insight into possible clocks. Because types IR benefit therapeutic approaches, describe chronotherapeutic strategies promote within
Язык: Английский
Процитировано
81
Sports Medicine, Год журнала: 2021, Номер 52(6), С. 1433 - 1448
Опубликована: Дек. 8, 2021
Язык: Английский
Процитировано
57
Diabetologia, Год журнала: 2022, Номер 66(3), С. 461 - 471
Опубликована: Ноя. 1, 2022
Abstract Aims/hypothesis We hypothesised that the insulin-sensitising effect of physical activity depends on timing activity. Here, we examined cross-sectional associations breaks in sedentary time and with liver fat content insulin resistance a Dutch cohort. Methods In 775 participants Netherlands Epidemiology Obesity (NEO) study, assessed time, different intensities using sensors, by magnetic resonance spectroscopy ( n =256). Participants were categorised as being most active morning (06:00–12:00 hours), afternoon (12:00–18:00 hours) or evening (18:00–00:00 engaging moderate-to-vigorous-physical (MVPA) evenly distributed throughout day. Most certain block was defined spending majority (%) total daily MVPA block. between HOMA-IR linear regression analyses, adjusted for demographic lifestyle factors including body fat. Associations additionally MVPA. Results The (42% men) had mean (SD) age 56 (4) years BMI 26.2 (4.1) kg/m 2 . Total not associated resistance, whereas amount higher content. (−5%/h [95% CI −10%/h, 0%/h]) reduced but Compared who an even distribution day, similar (−3% −25%, 16%]) those morning, it (−18% −33%, −2%]) (−25% −49%, −4%]). Conclusions/interpretation number lower resistance. Moderate-to-vigorous reduction up to 25% Further studies should assess whether is also important occurrence type diabetes. Graphical abstract
Язык: Английский
Процитировано
53
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Окт. 11, 2023
The biological clock system is an intrinsic timekeeping device that integrates internal physiology and external cues. Maintaining a healthy crucial for life. Disruptions to the body’s can lead disturbances in sleep-wake cycle abnormalities hormone regulation, blood pressure, heart rate, other vital processes. Long-term have been linked development of various common major diseases, including cardiovascular metabolic disorders, tumors, neuropsychiatric conditions, so on. External factors, such as diurnal rhythm light, significant impact on clock. Additionally, important non-photic zeitgeber, exercise regulate rhythms certain extent, making it possible become non-drug intervention preventing treating circadian disorders. This comprehensive review encompasses behavioral, physiological, molecular perspectives provide deeper understanding how influences its association with related diseases.
Язык: Английский
Процитировано
27
Neuroscience, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Biomolecules, Год журнала: 2021, Номер 11(4), С. 516 - 516
Опубликована: Март 30, 2021
The circadian rhythmicity of endogenous metabolic and hormonal processes is controlled by a complex system central peripheral pacemakers, influenced exogenous factors like light/dark-cycles, nutrition exercise timing. There evidence that alterations in this may be involved the pathogenesis diseases. It has been shown disruptions to normal diurnal rhythms lead drastic changes processes, as often seen modern society due excessive exposure unnatural light sources. Out that, research focused on time-restricted feeding exercise, both seem able reset pacemakers. Based these results personal physical goals, optimal time periods for food intake have identified. This review shows appropriate timing are powerful tools support, rather than not disturb, rhythm potentially contribute prevention Nevertheless, lifestyle interventions unable address real issue: misalignment our biological with social time.
Язык: Английский
Процитировано
42
Applied Sciences, Год журнала: 2022, Номер 12(18), С. 9220 - 9220
Опубликована: Сен. 14, 2022
Circadian rhythms are an inherent property of all living systems and essential part the external internal temporal order. They enable organisms to be synchronized with their periodic environment guarantee optimal functioning organisms. Any disturbances, so-called circadian disruptions, may have adverse consequences for health, physical mental performance, wellbeing. The environmental light–dark cycle is main zeitgeber rhythms. Moreover, regular activity most useful. Not only does it general favorable effects on cardiovascular system, energy metabolism example, but also stabilize system via feedback suprachiasmatic nuclei (SCN), pacemaker. Regular helps maintain high-amplitude rhythms, particularly clock gene expression in SCN. It promotes entrainment periodicities improves synchronization various This turn health In experiments Djungarian hamsters, voluntary access a running wheel not stabilized rhythm, intensive even reestablished rhythm arrhythmic individuals. cognitive abilities were restored. hamsters phenotype which SCN do generate signal diminished social memory compromised. Voluntary restored these simultaneously reestablishment rhythm. Intensively exercising Syrian less anxious, more resilient defeat, show defensive/submissive behaviors, i.e., exercise promote self-confidence. Similar described humans. aim present paper summarize current knowledge concerning stability corresponding performance.
Язык: Английский
Процитировано
32