PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis DOI Creative Commons
Chunxia Shi, Pan Cao, Yukun Wang

и другие.

Journal of Inflammation Research, Год журнала: 2023, Номер Volume 16, С. 1523 - 1532

Опубликована: Апрель 1, 2023

Abstract: PANoptosis is a new cell death proposed by Malireddi et al in 2019, which characterized pyroptosis, apoptosis and necroptosis, but cannot be explained any of them alone. The interaction between necroptosis involved PANoptosis. In this review, from the perspective PANoptosis, we focus on relationship key molecules process formation PANoptosome, as well role diseases. We aim to understand mechanism provide basis for targeted intervention PANoptosis-related treat human Keywords: apoptosis,

Язык: Английский

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes DOI Creative Commons
Rajendra Karki, Bhesh Raj Sharma, Shraddha Tuladhar

и другие.

Cell, Год журнала: 2020, Номер 184(1), С. 149 - 168.e17

Опубликована: Ноя. 18, 2020

Язык: Английский

Процитировано

1290

NLRP3 inflammasome in cancer and metabolic diseases DOI
Bhesh Raj Sharma, Thirumala‐Devi Kanneganti

Nature Immunology, Год журнала: 2021, Номер 22(5), С. 550 - 559

Опубликована: Март 11, 2021

Язык: Английский

Процитировано

768

Innate immunity: the first line of defense against SARS-CoV-2 DOI Open Access
Michael Diamond, Thirumala‐Devi Kanneganti

Nature Immunology, Год журнала: 2022, Номер 23(2), С. 165 - 176

Опубликована: Фев. 1, 2022

Язык: Английский

Процитировано

510

The regulation of the ZBP1‐NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis) DOI
Min Zheng, Thirumala‐Devi Kanneganti

Immunological Reviews, Год журнала: 2020, Номер 297(1), С. 26 - 38

Опубликована: Июль 29, 2020

Abstract ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA products but also endogenous nucleic acid ligands. sensing the Z‐RNA produced during influenza virus infection induces cell death in form pyroptosis, apoptosis, and necroptosis (PANoptosis). PANoptosis is coordinated pathway that driven through multiprotein complex called PANoptosome enables crosstalk co‐regulation among these processes. During infection, key step assembly formation ZBP1‐NLRP3 inflammasome. When sensed, recruits RIPK3 caspase‐8 to activate Several other host factors have found be important for inflammasome assembly, including molecules involved type I interferon signaling caspase‐6. Additionally, proteins, such M2, NS1, PB1‐F2, shown regulate This review explains functions mechanistic details underlying activation PANoptosome. Improved understanding will direct development therapeutic strategies target infectious inflammatory diseases.

Язык: Английский

Процитировано

359

From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways DOI Creative Commons
Yaqiu Wang, Thirumala‐Devi Kanneganti

Computational and Structural Biotechnology Journal, Год журнала: 2021, Номер 19, С. 4641 - 4657

Опубликована: Янв. 1, 2021

Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed cell death (PCD) pathways, they intricately involved in both homeostasis disease. Although identification of key initiators, effectors executioners each these three PCD pathways has historically delineated them as distinct, growing evidence highlighted extensive crosstalk among them. These observations have led to establishment concept PANoptosis, defined an inflammatory pathway regulated by PANoptosome complex with features pyroptosis, and/or that cannot be accounted for any alone. In this review, we provide a brief overview research history necroptosis. We then examine intricate discuss current PANoptosis. also detail molecular assembly complex, scaffold contemporaneous engagement molecules from apoptosis, PANoptosis is now known critically many diseases, including infection, sterile inflammation cancer, future discovery novel PANoptotic components will continue broaden our understanding fundamental processes inform development new therapeutics.

Язык: Английский

Процитировано

354

The ‘cytokine storm’: molecular mechanisms and therapeutic prospects DOI
Rajendra Karki, Thirumala‐Devi Kanneganti

Trends in Immunology, Год журнала: 2021, Номер 42(8), С. 681 - 705

Опубликована: Июль 1, 2021

Язык: Английский

Процитировано

279

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis DOI Creative Commons
Rajendra Karki, Balamurugan Sundaram, Bhesh Raj Sharma

и другие.

Cell Reports, Год журнала: 2021, Номер 37(3), С. 109858 - 109858

Опубликована: Окт. 1, 2021

Cell death provides host defense and maintains homeostasis. Zα-containing molecules are essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell death, PANoptosis, whereas adenosine deaminase acting on RNA (ADAR1) serves as an editor to maintain Here, we identify characterize ADAR1's interaction with ZBP1, defining its role in regulation tumorigenesis. Combining interferons (IFNs) nuclear export inhibitors (NEIs) ZBP1-dependent PANoptosis. ADAR1 suppresses this PANoptosis by interacting the Zα2 domain of ZBP1 limit RIPK3 interactions. Adar1

Язык: Английский

Процитировано

272

Programmed Cell Death Tunes Tumor Immunity DOI Creative Commons
Jing Liu,

Minjing Hong,

Yijia Li

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Март 30, 2022

The demise of cells in various ways enables the body to clear unwanted cells. Studies over years revealed distinctive molecular mechanisms and functional consequences several key cell death pathways. Currently, most intensively investigated programmed (PCD) includes apoptosis, necroptosis, pyroptosis, ferroptosis, PANoptosis, autophagy, which has been discovered play crucial roles modulating immunosuppressive tumor microenvironment (TME) determining clinical outcomes cancer therapeutic approaches. PCD can dual roles, either pro-tumor or anti-tumor, partly depending on intracellular contents released during process. also regulates enrichment effector regulatory immune cells, thus participating fine-tuning anti-tumor immunity TME. In this review, we focused primarily discussed messengers regulating their intricate crosstalk with response TME, explored immunological consequence its implications future therapy developments.

Язык: Английский

Процитировано

223

Programming inflammatory cell death for therapy DOI
Shelbi Christgen, Rebecca E. Tweedell, Thirumala‐Devi Kanneganti

и другие.

Pharmacology & Therapeutics, Год журнала: 2021, Номер 232, С. 108010 - 108010

Опубликована: Окт. 5, 2021

Язык: Английский

Процитировано

199

Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis DOI Creative Commons

Jin‐Fei Lin,

Peishan Hu,

Yiyu Wang

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Фев. 28, 2022

Metabolic enzymes have an indispensable role in metabolic reprogramming, and their aberrant expression or activity has been associated with chemosensitivity. Hence, targeting remains attractive approach for treating tumors. However, the influence regulation of cysteine desulfurase (NFS1), a rate-limiting enzyme iron-sulfur (Fe-S) cluster biogenesis, colorectal cancer (CRC) remain elusive. Here, using vivo gene-based clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 library screen, we revealed that loss NFS1 significantly enhanced sensitivity CRC cells to oxaliplatin. In vitro results showed deficiency synergizing oxaliplatin triggered PANoptosis (apoptosis, necroptosis, pyroptosis, ferroptosis) by increasing intracellular levels reactive oxygen species (ROS). Furthermore, oxaliplatin-based oxidative stress phosphorylation level serine residues NFS1, which prevented S293 phosphorylation-dependent manner during treatment. addition, high transcriptionally regulated MYC, was found tumor tissues poor survival hyposensitivity chemotherapy patients CRC. Overall, findings this study provided insights into underlying mechanisms identified inhibition as promising strategy improving outcome platinum-based treatment

Язык: Английский

Процитировано

195