Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 1523 - 1532
Published: April 1, 2023
Abstract:
PANoptosis
is
a
new
cell
death
proposed
by
Malireddi
et
al
in
2019,
which
characterized
pyroptosis,
apoptosis
and
necroptosis,
but
cannot
be
explained
any
of
them
alone.
The
interaction
between
necroptosis
involved
PANoptosis.
In
this
review,
from
the
perspective
PANoptosis,
we
focus
on
relationship
key
molecules
process
formation
PANoptosome,
as
well
role
diseases.
We
aim
to
understand
mechanism
provide
basis
for
targeted
intervention
PANoptosis-related
treat
human
Keywords:
apoptosis,
Immunological Reviews,
Journal Year:
2020,
Volume and Issue:
297(1), P. 26 - 38
Published: July 29, 2020
Abstract
ZBP1
has
been
characterized
as
a
critical
innate
immune
sensor
of
not
only
viral
RNA
products
but
also
endogenous
nucleic
acid
ligands.
sensing
the
Z‐RNA
produced
during
influenza
virus
infection
induces
cell
death
in
form
pyroptosis,
apoptosis,
and
necroptosis
(PANoptosis).
PANoptosis
is
coordinated
pathway
that
driven
through
multiprotein
complex
called
PANoptosome
enables
crosstalk
co‐regulation
among
these
processes.
During
infection,
key
step
assembly
formation
ZBP1‐NLRP3
inflammasome.
When
sensed,
recruits
RIPK3
caspase‐8
to
activate
Several
other
host
factors
have
found
be
important
for
inflammasome
assembly,
including
molecules
involved
type
I
interferon
signaling
caspase‐6.
Additionally,
proteins,
such
M2,
NS1,
PB1‐F2,
shown
regulate
This
review
explains
functions
mechanistic
details
underlying
activation
PANoptosome.
Improved
understanding
will
direct
development
therapeutic
strategies
target
infectious
inflammatory
diseases.
Computational and Structural Biotechnology Journal,
Journal Year:
2021,
Volume and Issue:
19, P. 4641 - 4657
Published: Jan. 1, 2021
Pyroptosis,
apoptosis
and
necroptosis
are
the
most
genetically
well-defined
programmed
cell
death
(PCD)
pathways,
they
intricately
involved
in
both
homeostasis
disease.
Although
identification
of
key
initiators,
effectors
executioners
each
these
three
PCD
pathways
has
historically
delineated
them
as
distinct,
growing
evidence
highlighted
extensive
crosstalk
among
them.
These
observations
have
led
to
establishment
concept
PANoptosis,
defined
an
inflammatory
pathway
regulated
by
PANoptosome
complex
with
features
pyroptosis,
and/or
that
cannot
be
accounted
for
any
alone.
In
this
review,
we
provide
a
brief
overview
research
history
necroptosis.
We
then
examine
intricate
discuss
current
PANoptosis.
also
detail
molecular
assembly
complex,
scaffold
contemporaneous
engagement
molecules
from
apoptosis,
PANoptosis
is
now
known
critically
many
diseases,
including
infection,
sterile
inflammation
cancer,
future
discovery
novel
PANoptotic
components
will
continue
broaden
our
understanding
fundamental
processes
inform
development
new
therapeutics.
Cell Reports,
Journal Year:
2021,
Volume and Issue:
37(3), P. 109858 - 109858
Published: Oct. 1, 2021
Cell
death
provides
host
defense
and
maintains
homeostasis.
Zα-containing
molecules
are
essential
for
these
processes.
Z-DNA
binding
protein
1
(ZBP1)
activates
inflammatory
cell
death,
PANoptosis,
whereas
adenosine
deaminase
acting
on
RNA
(ADAR1)
serves
as
an
editor
to
maintain
Here,
we
identify
characterize
ADAR1's
interaction
with
ZBP1,
defining
its
role
in
regulation
tumorigenesis.
Combining
interferons
(IFNs)
nuclear
export
inhibitors
(NEIs)
ZBP1-dependent
PANoptosis.
ADAR1
suppresses
this
PANoptosis
by
interacting
the
Zα2
domain
of
ZBP1
limit
RIPK3
interactions.
Adar1
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: March 30, 2022
The
demise
of
cells
in
various
ways
enables
the
body
to
clear
unwanted
cells.
Studies
over
years
revealed
distinctive
molecular
mechanisms
and
functional
consequences
several
key
cell
death
pathways.
Currently,
most
intensively
investigated
programmed
(PCD)
includes
apoptosis,
necroptosis,
pyroptosis,
ferroptosis,
PANoptosis,
autophagy,
which
has
been
discovered
play
crucial
roles
modulating
immunosuppressive
tumor
microenvironment
(TME)
determining
clinical
outcomes
cancer
therapeutic
approaches.
PCD
can
dual
roles,
either
pro-tumor
or
anti-tumor,
partly
depending
on
intracellular
contents
released
during
process.
also
regulates
enrichment
effector
regulatory
immune
cells,
thus
participating
fine-tuning
anti-tumor
immunity
TME.
In
this
review,
we
focused
primarily
discussed
messengers
regulating
their
intricate
crosstalk
with
response
TME,
explored
immunological
consequence
its
implications
future
therapy
developments.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Feb. 28, 2022
Metabolic
enzymes
have
an
indispensable
role
in
metabolic
reprogramming,
and
their
aberrant
expression
or
activity
has
been
associated
with
chemosensitivity.
Hence,
targeting
remains
attractive
approach
for
treating
tumors.
However,
the
influence
regulation
of
cysteine
desulfurase
(NFS1),
a
rate-limiting
enzyme
iron-sulfur
(Fe-S)
cluster
biogenesis,
colorectal
cancer
(CRC)
remain
elusive.
Here,
using
vivo
gene-based
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)-Cas9
library
screen,
we
revealed
that
loss
NFS1
significantly
enhanced
sensitivity
CRC
cells
to
oxaliplatin.
In
vitro
results
showed
deficiency
synergizing
oxaliplatin
triggered
PANoptosis
(apoptosis,
necroptosis,
pyroptosis,
ferroptosis)
by
increasing
intracellular
levels
reactive
oxygen
species
(ROS).
Furthermore,
oxaliplatin-based
oxidative
stress
phosphorylation
level
serine
residues
NFS1,
which
prevented
S293
phosphorylation-dependent
manner
during
treatment.
addition,
high
transcriptionally
regulated
MYC,
was
found
tumor
tissues
poor
survival
hyposensitivity
chemotherapy
patients
CRC.
Overall,
findings
this
study
provided
insights
into
underlying
mechanisms
identified
inhibition
as
promising
strategy
improving
outcome
platinum-based
treatment
