Risk factors for severe COVID-19 infection and the impact of COVID-19 infection on disease progression among patients with AAV
Abstract
Objective
To
identify
risk
factors
for
COVID-19
infection
and
investigate
the
impact
of
on
chronic
kidney
disease
(CKD)
progression
vasculitis
flare
in
patients
with
antineutrophil
cytoplasmic
antibody
(ANCA)-associated
(AAV).
Methods
This
cohort
study
retrospectively
analyzed
prevalence
severity
276
AAV
who
were
followed
up.
Logistic
regression
was
employed
to
estimate
as
well
CKD
upon
infection.
Results
During
6-month
observation
period,
213
(77.2%)
had
a
diagnosis
Of
these
patients,
49
(23.0%)
COVID-19-related
inpatient
admission,
including
17
died
severe
more
likely
be
male
(OR
1.921
[95%
CI
1.020–3.619],
P
=
0.043),
suffered
from
worse
function
(serum
creatinine
[Scr],
OR
1.901
1.345–2.687],
<
0.001),
higher
C-reactive
protein
(CRP)
1.054
1.010–1.101],
0.017)
less
have
evidence
initial
vaccination
0.469
0.231–0.951],
0.036),
Scr
proven
significantly
associated
even
after
multivariable
adjustment.
Severe
subsequent
7.929
2.030-30.961],
0.003)
11.842
1.048-133.835],
0.046)
among
AAV.
Conclusion
male,
susceptible
infection,
which
subsequently
increased
flare.
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Фев. 9, 2024
Язык: Английский
