Metabolomic and Physiological Effects of a Cardiorenal Protective Diet Intervention in African American Adults with Chronic Kidney Disease DOI Creative Commons
Meera Patel,

Chiamaka Emerenini,

Xuan Wang

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 300 - 300

Published: May 25, 2024

Chronic kidney disease (CKD) impacts 14% of adults in the United States, and African American (AA) individuals are disproportionately affected, with more than 3 times higher risk failure as compared to White individuals. This study evaluated effects base-producing fruit vegetables (FVs) on cardiorenal outcomes AA persons CKD hypertension (HTN) a low socioeconomic area. The “Cardiorenal Protective Diet” prospective randomized trial 6-week, community-based FV intervention waitlist control (WL) 91 (age = 58.3 ± 10.1 years, 66% female, 48% income ≤ USD 25K). Biometric metabolomic variables were collected at baseline 6 weeks post-intervention. change health for both groups was statistically insignificant (p > 0.05), though small reductions albumin creatinine ratio, body mass index, total cholesterol, systolic blood pressure observed group. Metabolomic profiling identified key markers < including C3, C5, 1-Met-His, kynurenine, PC ae 38:5, choline, indicating function decline WL Overall, delivering directed protective diet improved HTN. Additionally, may serve prognostic technique early identification biomarkers indicators worsening increased CVD risk.

Language: Английский

Arteriovenous metabolomics in pigs reveals CFTR regulation of metabolism in multiple organs DOI Creative Commons
Hosung Bae, Bo Ram Kim,

Sunhee Jung

et al.

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(13)

Published: May 14, 2024

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause (CF), a multiorgan disease that is characterized by diverse metabolic defects. However, other than specific CFTR mutations, factors influence progression and severity remain poorly understood. Aberrant metabolite levels have been reported, but whether loss itself or secondary abnormalities (infection, inflammation, malnutrition, various treatments) drive defects uncertain. Here, we implemented comprehensive arteriovenous metabolomics newborn CF pigs, results revealed as bona fide of metabolism. impaired exchange across organs, including disruption lung uptake fatty acids, yet enhancement arachidonic acid, precursor proinflammatory cytokines. also kidney reabsorption amino acids lactate abolished renal glucose homeostasis. These additional unexpected prior to manifestations reveal fundamental role for controlling Such discovery informs basic understanding CF, provides foundation future investigation, has implications developing therapies targeting only single tissue.

Language: Английский

Citations

6
Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study DOI Open Access
Kendra E. Wulczyn, Tariq Shafi, Amanda H. Anderson

et al.

American Journal of Kidney Diseases, Journal Year: 2024, Volume and Issue: 84(1), P. 49 - 61.e1

Published: Jan. 23, 2024

Language: Английский

Citations

5
Canagliflozin attenuates kidney injury, gut-derived toxins, and gut microbiota imbalance in high-salt diet-fed Dahl salt-sensitive rats DOI Creative Commons
Lili He, Qingjuan Zuo, Sai Ma

et al.

Renal Failure, Journal Year: 2024, Volume and Issue: 46(1)

Published: Jan. 8, 2024

Purpose To investigate the effects of canagliflozin (20 mg/kg) on Dahl salt-sensitive (DSS) rat gut microbiota and hypertension-induced kidney injury further explore its possible mechanism.

Language: Английский

Citations

4
Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression DOI Creative Commons
Pascal Schlosser, Aditya Surapaneni, Oleg Borisov

et al.

Journal of the American Society of Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: April 19, 2024

Key Points Integrated analysis of proteome and metabolome identifies modules associated with CKD progression kidney failure. Ephrin transmembrane proteins podocyte-expressed CRIM1 NPNT emerged as central components warrant experimental clinical investigation. Background Proteins metabolites play crucial roles in various biological functions are frequently interconnected through enzymatic or transport processes. Methods We present an integrated 4091 630 the Chronic Renal Insufficiency Cohort study ( N =1708; average follow-up for failure, 9.5 years, 537 events). were using unsupervised clustering method, we assessed associations between clusters failure Cox proportional hazards models. Analyses adjusted demographics risk factors, including eGFR urine protein–creatinine ratio. Associations identified a discovery sample (random two thirds, n =1139) then evaluated replication (one third, =569). Results 139 correlated metabolites, which represented by their principal components. Modules component loadings projected onto sample, demonstrated consistent network structure. Two modules, representing total 236 82 robustly both validation samples. Using gene set enrichment, several transmembrane-related terms overrepresented these modules. Transmembrane–ephrin receptor activity displayed largest odds (odds ratio=13.2, P value = 5.5×10 −5 ). A module containing expressed podocytes particularly strong 2.6×10 Conclusions This demonstrates that integration can identify pathophysiologic importance disease.

Language: Английский

Citations

4
Proteomics profiling and association with cardiorenal complications in type 2 diabetes subtypes in Asian population DOI
Resham L Gurung, Huili Zheng,

Bernett Teck Kwong Lee

et al.

Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 214, P. 111790 - 111790

Published: July 25, 2024

Language: Английский

Citations

4
Mechanisms of Homoarginine: Looking Beyond Clinical Outcomes DOI Creative Commons
Ashley Zubkowski, Amanda N. Sferruzzi‐Perri, David S. Wishart

et al.

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(2)

Published: Jan. 16, 2025

Abstract Purpose Homoarginine (hArg) is an arginine metabolite that has been known for years, but its physiological role in the body remains poorly understood. For instance, it well high hArg concentrations blood are protective against several disease states, yet mechanisms behind these health benefits unclear. This review compiles what about hArg, namely synthetic pathways, different diseases and conditions, proposed of action humans experimental animals. Findings Previous work identified multiple pathways control synthesis degradation body. Furthermore, endogenous can modulate cardiovascular system, with decreased being associated complications increased mortality. Studies also suggest could serve as a diagnostic biomarker variety immune, pancreatic, renal, hepatic dysfunctions. Finally, women, rapidly increase throughout pregnancy there suggestions alterations indicate like pre‐eclampsia. Summary under‐appreciated amino acid potential wide‐ranging roles systemic health, pregnancy, pathophysiology. Although recent research focused on or associations, need more investigations into understanding mechanistic by which may operate. be aided using metabolomics, provides comprehensive approach to correlating metabolites metabolic effects. Increasing our knowledge hArg's pave way routine use both therapeutic molecule.

Language: Английский

Citations

0
Analyses of Saliva Metabolome Reveal Patterns of Metabolites That Differentiate SARS-CoV-2 Infection and COVID-19 Disease Severity DOI Creative Commons
Violeta Larios‐Serrato, Natalia Vázquez-Manjarrez, Osbaldo Resendis‐Antonio

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 192 - 192

Published: March 11, 2025

Background: The metabolome of COVID-19 patients has been studied sparsely, with most research focusing on a limited number plasma metabolites or small cohorts. This is the first study to test saliva in comprehensive way, revealing patterns significantly linked disease and severity, highlighting saliva’s potential as non-invasive tool for pathogenesis diagnostic studies. Methods: We included 30 asymptomatic subjects no prior infection vaccination, 102 mild SARS-CoV-2 infection, 61 hospitalized confirmed status. Saliva samples were analyzed using hydrophilic interaction liquid chromatography–mass spectrometry (HILIC-MS/MS) positive negative ionization modes. Results: Significant differences identified patients, distinct associated severity. Dipeptides such Val-Glu Met-Gln highly elevated moderate cases, suggesting specific protease activity related SARS-CoV-2. Acetylated amino acids like N-acetylserine N-acetylhistidine increased severe cases. Bacterial metabolites, including muramic acid indole-3-carboxaldehyde, higher mild–moderate indicating that oral microbiota differs according In polyamines organ-damage-related N-acetylspermine 3-methylcytidine, increased. Interestingly, reduced cases Conclusions: metabolomics offers insightful information potentially useful studying severity diagnosis.

Language: Английский

Citations

0
Imaging and spatially resolved mass spectrometry applications in nephrology DOI
Brittney Gorman,

Catelynn C. Shafer,

Nagarjunachary Ragi

et al.

Nature Reviews Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Citations

0
Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints DOI Creative Commons
Xianyong Yin,

Jack Li,

Debraj Bose

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 28, 2025

Metabolites are small molecules that useful for estimating disease risk and elucidating biology. Here, we perform two-sample Mendelian randomization to systematically infer the potential causal effects of 1099 plasma metabolites measured in 6136 Finnish men from METSIM study on 2099 binary endpoints 309,154 individuals FinnGen. We find evidence 282 putative 70 183 endpoints. also identify 25 with across multiple domains, including ascorbic acid 2-sulfate affecting 26 12 domains. Our suggests N-acetyl-2-aminooctanoate glycocholenate sulfate affect atrial fibrillation through two distinct metabolic pathways N-methylpipecolate may mediate effect N6,N6-dimethyllysine anxious personality disorder.

Language: Английский

Citations

0
Obesity‐related glomerulopathy: How it happens and future perspectives DOI Creative Commons
Jian‐Wen Samuel Lee‐Boey, Juan Tan,

Zi Yi Lim

et al.

Diabetic Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract Obesity‐related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% individuals can be affected by ORG, irrespective status glomerular filtration rate and albuminuria. ORG a distinct histological diagnosis based on kidney biopsy, showing classical features enlarged glomerulus with without focal segmental glomerulosclerosis in perihilar region seen all categories obesity. About 10% may progress end‐stage disease. The invasive nature biopsy highlights need for non‐invasive biomarkers improved screening, risk prediction ORG. These narrow gaps management improving: (1) differentiation from non‐ORG conditions; (2) stratification at progression disease including detection trajectories progression; (3) monitoring treatment safety effectiveness (4) development novel therapeutic targets. In present review, we discussed pathophysiology, (such as injury molecule‐1 [KIM‐1], uromodulin, klotho, circulating microRNA‐21 [miR‐21]) future strategies (metabolic surgery, sodium‐glucose cotransporter‐2 inhibitors, incretin‐based therapy non‐steroidal mineralocorticoid antagonists)

Language: Английский

Citations

0