Diagnostics, Год журнала: 2024, Номер 14(21), С. 2462 - 2462
Опубликована: Ноя. 4, 2024
Biliary tract cancer (BTC) is a rare but aggressive malignancy that requires surgical treatment. However, postoperative recurrence rates are high, and reliable predictors of limited. This study aimed to investigate the effectiveness cell-free DNA (cfDNA) circulating tumor cells (CTCs) in predicting early after curative surgery complete adjuvant therapy patients with BTC.
Язык: Английский
Journal of Experimental & Clinical Cancer Research, Год журнала: 2025, Номер 44(1)
Опубликована: Фев. 12, 2025
Abstract Background Liquid biopsy (LB) offers a promising, minimally invasive alternative to traditional tissue biopsies in cancer care, enabling real-time monitoring and personalized treatment. Despite its potential, the routine implementation of LB clinical practice faces significant challenges. This scoping review examines barriers facilitators influencing liquid into standard care. Methods Four academic databases (PubMed, Scopus, Embase, Web Science) were systematically searched without language restrictions. We included peer-reviewed articles that published between January 2019 March 2024 focused on care or described implementation. Data relevant objective, including key article characteristics; implementation; recommendations for advancement optimisation; extracted analysed using thematic visual network analyses. Results The majority narrative (84%), with most from China (24.2%) United States (20%). Thematic analysis identified four main categories their associated care: (1) Laboratory personnel requirements; (2) Disease specificity; (3) Biomarker-based biopsy; (4) Policy regulation. concentrated pre-analytical phase, highlighting lack standardization technologies outcomes. Conclusions Through implementation, we present an integrated tool designed encourage testing methods guidelines field.
Язык: Английский
Процитировано
1
Microorganisms, Год журнала: 2024, Номер 12(7), С. 1482 - 1482
Опубликована: Июль 19, 2024
Head and neck cancers (HNCs) constitute a wide range of malignancies originating from the epithelial lining upper aerodigestive tract, including oral cavity, pharynx, larynx, nasal paranasal sinuses, salivary glands. Although lymphomas affecting this region are not conventionally classified as HNCs, they may occur in lymph nodes or mucosa-associated lymphoid tissues within head neck. Oncogenic viruses play crucial role HNC onset. Human papillomavirus (HPV) is extensively studied for its association with oropharyngeal cancers; nevertheless, other oncogenic also contribute to development. This review provides an overview epidemiology, pathogenesis, advancements detection methods associated recognizing HPV's well-established while exploring additional viral connections. Notably, Epstein-Barr virus linked nasopharyngeal carcinoma lymphomas. herpesvirus 8 implicated Kaposi's sarcoma, Merkel cell polyomavirus subsets HNCs. Additionally, hepatitis examined their potential Understanding contributions area critical refining therapeutic approaches. underlines interaction between region, highlighting necessity ongoing research elucidate mechanisms enhance clinical outcomes.
Язык: Английский
Процитировано
7
Oral Oncology, Год журнала: 2025, Номер 162, С. 107208 - 107208
Опубликована: Фев. 2, 2025
Язык: Английский
Процитировано
0
Oral Oncology, Год журнала: 2025, Номер 163, С. 107234 - 107234
Опубликована: Март 5, 2025
Язык: Английский
Процитировано
0
Oral Oncology, Год журнала: 2025, Номер 164, С. 107262 - 107262
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Med, Год журнала: 2025, Номер unknown, С. 100646 - 100646
Опубликована: Апрель 1, 2025
Urinary cell-free DNA (ucfDNA) is a valuable resource for truly non-invasive liquid biopsy. UcfDNA comprises transrenal ucfDNA passing from the bloodstream through glomeruli and locally shed urinary-tract ucfDNA. Understanding their differences in characteristics may enable new diagnostic applications. We analyzed 136 samples healthy controls, pregnant women, patients with chronic kidney diseases (CKDs), bladder cancer using massively parallel sequencing. Fragmentomic including fragment sizes 5' end motifs were deduced. The relationship between chromatin accessibility was examined by overlapping open regions (OCRs, lacking histones) heterochromatin (HCRs, tightly packed histones). Compared ucfDNA, shorter enriched C-ends. over-represented OCRs but depleted HCRs, indicating an interplay glomerular filtration barrier effective cfDNA size. In proteinuria (preeclampsia CKDs), amount of HCRs increased, suggesting elevated permeability histone-bound plasma molecules. oncology, use hypomethylation signals enhanced detection, area under receiver operating characteristic curve 0.93. Chromatin states impact clearance DNA, likely size restriction barrier. This realization has enabled rational development novel approaches detecting or monitoring renal dysfunction urological cancers. Innovation Technology Commission Hong Kong SAR Government (InnoHK initiative) Li Ka Shing Foundation supported this study.
Язык: Английский
Процитировано
0
Опубликована: Авг. 21, 2024
Recent data has shown a continued rise in the worldwide annual incidence and mortality rates of head neck cancers. The present standard for diagnosis monitoring disease recurrence or progression involves clinical examination, imaging, invasive biopsy techniques lesions suspected being malignant. In addition to limitations relating cost, time, patient discomfort, these methodologies have inherent inaccuracies detecting recurrence. view limitations, analysis bodily fluid samples via liquid proposes cost-effective convenient alternative, which provides insight on biogenetic biomolecular underpinnings oncologic processes. Liquid biopsy’s biomarkers cancer, including circulating tumor DNA, cells, cell-free RNA, utility screening, diagnosis, prognostication, patients with various forms cancer. review will provide an update current literature examining use cancer care applicability potential biomarkers, focus viral non-viral DNA. Possible future avenues research address specific shortcomings be discussed.
Язык: Английский
Процитировано
1
Cancers, Год журнала: 2024, Номер 16(18), С. 3129 - 3129
Опубликована: Сен. 11, 2024
Recent data have shown a continued rise in the worldwide annual incidence and mortality rates of head neck cancers. The present standard for diagnosis monitoring disease recurrence or progression involves clinical examination, imaging, invasive biopsy techniques lesions suspected being malignant. In addition to limitations relating cost, time, patient discomfort, these methodologies inherent inaccuracies detecting recurrence. view limitations, analysis bodily fluid samples via liquid proposes cost-effective convenient alternative, which provides insight on biogenetic biomolecular underpinnings oncologic processes. biomarkers cancer biopsy, including circulating tumor DNA, cells, cell-free RNA, has utility screening, diagnosis, prognostication, patients with various forms cancer. review will provide an update current literature examining use care applicability potential biomarkers, focus viral non-viral DNA. Possible future avenues research address specific shortcomings be discussed.
Язык: Английский
Процитировано
1
Diagnostics, Год журнала: 2024, Номер 14(21), С. 2462 - 2462
Опубликована: Ноя. 4, 2024
Biliary tract cancer (BTC) is a rare but aggressive malignancy that requires surgical treatment. However, postoperative recurrence rates are high, and reliable predictors of limited. This study aimed to investigate the effectiveness cell-free DNA (cfDNA) circulating tumor cells (CTCs) in predicting early after curative surgery complete adjuvant therapy patients with BTC.
Язык: Английский
Процитировано
0