Aging,
Год журнала:
2023,
Номер
15(7), С. 2705 - 2720
Опубликована: Апрель 7, 2023
Background:
Neuroinflammation
is
a
frequent
cause
of
brain
damage
after
intracerebral
hemorrhage
(ICH).
Gut
microbiota
are
reported
to
regulate
neuroinflammation.
Berberine
has
been
found
have
anti-inflammatory
actions,
including
in
the
central
nervous
system.
However,
it
not
known
whether
berberine
regulates
neuroinflammation
ICH,
nor
relationship
between
antineuroinflammatory
actions
and
gut
ICH
understood.
Methods:
was
induced
male
mice
by
collagenase
injection.
Immunofluorescent
staining
quantitative
real-time
polymerase
chain
reaction
(qRT-PCR)
were
performed
detect
microglia/macrophage
phenotypes.
staining,
ELISA,
FITC-dextran
conducted
determine
function.
16S
rRNA
sequencing
fecal
material
alterations
microbiota.
Antibiotic
cocktail
treatment
transplantation
(FMT)
used
deplete
or
restore
microbiota,
respectively.
Cylinder,
forelimb
placement
wire
hanging
tests
evaluate
neurobehavioral
Results:
significantly
reduced
alleviated
neurological
dysfunction
preventing
microglial/macrophage
proinflammatory
polarization
mice.
also
enhanced
function
intestinal
barrier,
as
shown
reductions
levels
lipopolysaccharide-binding
protein.
markedly
from
berberine-treated
mice,
similar
with
oral
berberine.
In
addition,
reduction
reversed
neuroprotective
effect
Conclusions:
potential
for
ICH-induced
neuroinflammation,
its
effects
at
least
partially
dependent
on
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Май 30, 2022
Abstract
Evidence
from
human
cohorts
indicates
that
chronic
insomnia
is
associated
with
higher
risk
of
cardiometabolic
diseases
(CMD),
yet
whether
gut
microbiota
plays
a
role
unclear.
Here,
in
longitudinal
cohort
(
n
=
1809),
we
find
the
microbiota-bile
acid
axis
may
link
positive
association
between
and
CMD.
Ruminococcaceae
UCG-002
UCG-003
are
main
genera
mediating
These
results
also
observed
an
independent
cross-sectional
6122).
The
inverse
associations
those
microbial
biomarkers
CMD
mediated
by
certain
bile
acids
(isolithocholic
acid,
muro
cholic
nor
acid).
Habitual
tea
consumption
prospectively
identified
opposite
direction
compared
insomnia.
Our
work
suggests
be
potential
intervention
target
for
reducing
impact
on
health.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 6, 2023
The
system
physiology
approaches
that
emerge
in
western
countries
recent
years
echo
the
holistic
view
of
ancient
Traditional
Chinese
Medicine
(TCM)
practices
deal
with
root,
rather
than
only
symptoms
diseases.
Particularly,
TCM
practices,
including
acupuncture,
emphasize
mobilization
self-healing
mechanisms
to
bring
back
body
homeostasis.
Acupuncture
has
been
practiced
for
over
two
thousand
modulate
via
stimulation
at
specific
regions
(acupoints).
With
development
various
research
on
acupuncture
therapy,
its
regulatory
effect
immune
gradually
recognized,
especially
immunological
diseases,
infectious
and
allergic
In
this
study,
we
reviewed
immunomodulatory
mechanism
systematically
integrates
existing
respectively
elucidate
modulatory
innate
system,
adaptive
well-known
neuroanatomical
mechanisms,
intact
somatosensory-autonomic
reflex
pathway.
advances
made
systems
studies,
now
have
a
great
opportunity
gain
insight
into
how
modulates
immunity,
subsequently
improves
efficacy.
Materials Today Bio,
Год журнала:
2022,
Номер
15, С. 100278 - 100278
Опубликована: Май 10, 2022
The
efficacy
of
neural
repair
and
regeneration
strategies
for
traumatic
brain
injury
(TBI)
treatment
is
greatly
hampered
by
the
harsh
lesion
microenvironment
including
oxidative
stress
hyper-inflammatory
response.
Functionalized
hydrogel
with
capability
suppression
neuroinflammation
inhibition
will
contribute
to
repairment
TBI.
Herein,
antioxidant
gallic
acid-grafted
hyaluronic
acid
(HGA)
was
combined
acid-tyramine
(HT)
polymer
develop
an
injectable
dual-enzymatically
crosslinking
method.
resulting
HT/HGA
biocompatible
possesses
effective
scavenging
activity
against
DPPH
hydroxyl
radicals.
Meanwhile,
this
improved
cell
viability
reduced
intracellular
reactive
oxygen
species
(ROS)
production
under
H2O2
insult.
in
vivo
study
showed
that
situ
injection
significantly
malondialdehyde
(MDA)
increased
glutathione
(GSH)
expression
area
after
3
or
21
days,
which
might
be
associated
activation
Nrf2/HO-1
pathway.
Furthermore,
promoted
microglia
polarization
M2
(Arg1)
phenotype,
it
also
decreased
level
proinflammatory
factors
TNF-α
IL-6
anti-inflammatory
factor
IL-4.
Finally,
blood-brain
barrier
(BBB)
protected,
neurogenesis
hippocampus
promoted,
motor,
learning
memory
ability
enhanced.
Therefore,
injectable,
biocompatible,
exhibits
a
huge
potential
treating
TBI
allows
us
recognize
great
value
novel
biomaterial
remodeling
structure
function.
Biomedicines,
Год журнала:
2022,
Номер
10(2), С. 500 - 500
Опубликована: Фев. 21, 2022
Communication
between
the
enteric
nervous
system
(ENS)
of
gastrointestinal
(GI)
tract
and
central
(CNS)
is
vital
for
maintaining
systemic
homeostasis.
Intrinsic
extrinsic
neurological
inputs
gut
regulate
blood
flow,
peristalsis,
hormone
release,
immunological
function.
The
health
microbiome
plays
a
role
in
regulating
overall
function
well-being
individual.
Microbes
release
short-chain
fatty
acids
(SCFAs)
that
G-protein-coupled
receptors
to
mediate
neurotransmitter
(i.e.,
serotonin,
dopamine,
noradrenaline,
γ-aminobutyric
acid
(GABA),
acetylcholine,
histamine),
inflammation
mood.
Further
gaseous
factors
nitric
oxide)
are
important
have
response
injury.
Neurologic
injuries
such
as
ischemic
stroke,
spinal
cord
injury,
traumatic
brain
hemorrhagic
cerebrovascular
lesions
can
all
lead
dysbiosis.
Additionally,
unfavorable
alterations
composition
microbiota
may
be
associated
with
increased
risk
these
neurologic
due
proinflammatory
molecules
clotting
factors.
Interventions
probiotics,
fecal
transplantation,
oral
SCFAs
been
shown
stabilize
improve
microbiome.
However,
effect
this
has
on
injury
prevention
recovery
not
studied
extensively.
purpose
review
elaborate
complex
relationship
report
how
modulates
status
Finally,
we
will
propose
various
interventions
beneficial
from
Journal of Medicinal Chemistry,
Год журнала:
2023,
Номер
66(21), С. 14447 - 14473
Опубликована: Окт. 25, 2023
NLRP3
inflammasome
is
a
multiprotein
complex
involved
in
host
immune
response─which
exerts
various
biological
effects
by
mediating
the
maturation
and
secretion
of
IL-1β
IL-18─and
pyroptosis.
However,
its
aberrant
activation
could
cause
amplification
inflammatory
effects,
thereby
triggering
range
ailments,
including
Alzheimer's
disease,
Parkinson's
rheumatoid
arthritis,
gout,
type
2
diabetes
mellitus,
cancer.
For
past
few
years,
as
an
attractive
anti-inflammatory
target,
NLRP3-targeting
small-molecule
inhibitors
have
been
widely
reported
both
academic
industrial
communities.
In
order
to
deeply
understand
advancement
inhibitors,
we
provide
comprehensive
insights
commentary
on
drugs
currently
under
clinical
investigation,
well
other
from
chemical
structure
point
view,
with
aim
new
for
further
development
inflammasome-mediated
diseases.
Biomedicines,
Год журнала:
2023,
Номер
11(10), С. 2630 - 2630
Опубликована: Сен. 25, 2023
Historically,
cannabis
has
been
valued
for
its
pain-relieving,
anti-inflammatory,
and
calming
properties.
Ancient
civilizations
like
the
Egyptians,
Greeks,
Chinese
medicines
recognized
their
therapeutic
potential.
The
discovery
of
endocannabinoid
system,
which
interacts
with
phytoconstituents,
scientifically
explained
how
affects
human
immune
including
central
nervous
system
(CNS).
This
review
explores
evolving
world
cannabis-based
treatments,
spotlighting
diverse
applications.
By
researching
current
research
clinical
studies,
we
probe
into
cannabinoids
Δ9-tetrahydrocannabinol
(THC)
cannabidiol
(CBD)
help
to
manage
conditions
ranging
from
chronic
pain,
persistent
inflammation,
cancer,
inflammatory
bowel
disease,
neurological
disorders
even
viral
diseases
such
as
Human
Immunodeficiency
virus
(HIV),
SARS-CoV-2.
emerging
monkeypox.
long-term
recreational
use
can
develop
disorder
(CUD),
therefore,
understanding
factors
contributing
development
maintenance
addiction,
genetic
predisposition,
neurobiological
mechanisms,
environmental
influences,
will
be
timely.
Shedding
light
on
adverse
impacts
CUD
underscores
importance
early
intervention,
effective
treatment
approaches,
public
health
initiatives
address
this
complex
issue
in
an
landscape
policies
perceptions.
Abstract
Starting
from
the
perspective
of
an
immune-privileged
site,
our
knowledge
inflammatory
processes
within
central
nervous
system
has
increased
rapidly
over
last
30
years,
leading
to
a
rather
puzzling
picture
today.
Of
particular
interest
is
emergence
disease-
and
injury-specific
responses
brain,
which
may
form
basis
for
future
therapeutic
approaches.
To
advance
this
important
topic,
we
invite
authors
contribute
research
clinical
papers
Collection
“Neuroinflammation
Brain
Disease”.
