YTHDF1 Attenuates TBI-Induced Brain-Gut Axis Dysfunction in Mice DOI Open Access
Peizan Huang, Min Liu, Jing Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4240 - 4240

Published: Feb. 20, 2023

The brain-gut axis (BGA) is a significant bidirectional communication pathway between the brain and gut. Traumatic injury (TBI) induced neurotoxicity neuroinflammation can affect gut functions through BGA. N6-methyladenosine (m6A), as most popular posttranscriptional modification of eukaryotic mRNA, has recently been identified playing important roles in both However, whether m6A RNA methylation involved TBI-induced BGA dysfunction not clear. Here, we showed that YTHDF1 knockout reduced histopathological lesions decreased levels apoptosis, inflammation, oedema proteins tissues mice after TBI. We also found improved fungal mycobiome abundance probiotic (particularly Akkermansia) colonization at 3 days post-CCI. Then, differentially expressed genes (DEGs) cortex YTHDF1-knockout WT mice. These were primarily enriched regulation neurotransmitter-related neuronal signalling pathways, inflammatory apoptotic pathways. This study reveals ITGA6-mediated cell adhesion molecule may be key feature dysfunction. Our results suggest could attenuate

Language: Английский

The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases DOI Creative Commons
Zengliang Jiang,

Lai‐Bao Zhuo,

Yan He

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: May 30, 2022

Abstract Evidence from human cohorts indicates that chronic insomnia is associated with higher risk of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role unclear. Here, in longitudinal cohort ( n = 1809), we find the microbiota-bile acid axis may link positive association between and CMD. Ruminococcaceae UCG-002 UCG-003 are main genera mediating These results also observed an independent cross-sectional 6122). The inverse associations those microbial biomarkers CMD mediated by certain bile acids (isolithocholic acid, muro cholic nor acid). Habitual tea consumption prospectively identified opposite direction compared insomnia. Our work suggests be potential intervention target for reducing impact on health.

Language: Английский

Citations

98
The immunomodulatory mechanisms for acupuncture practice DOI Creative Commons
Meng Wang, Weili Liu,

Jiayi Ge

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 6, 2023

The system physiology approaches that emerge in western countries recent years echo the holistic view of ancient Traditional Chinese Medicine (TCM) practices deal with root, rather than only symptoms diseases. Particularly, TCM practices, including acupuncture, emphasize mobilization self-healing mechanisms to bring back body homeostasis. Acupuncture has been practiced for over two thousand modulate via stimulation at specific regions (acupoints). With development various research on acupuncture therapy, its regulatory effect immune gradually recognized, especially immunological diseases, infectious and allergic In this study, we reviewed immunomodulatory mechanism systematically integrates existing respectively elucidate modulatory innate system, adaptive well-known neuroanatomical mechanisms, intact somatosensory-autonomic reflex pathway. advances made systems studies, now have a great opportunity gain insight into how modulates immunity, subsequently improves efficacy.

Language: Английский

Citations

71
Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke DOI Creative Commons

Mingxu Duan,

Ya Xu,

Yuanshu Li

et al.

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: April 18, 2024

Abstract The notion that the central nervous system is an immunologically immune-exempt organ has changed over past two decades, with increasing evidence of strong links and interactions between peripheral immune system, both in healthy state after ischemic hemorrhagic stroke. Although primary injury stroke certainly important, limited therapeutic efficacy, poor neurological prognosis high mortality have led researchers to realize secondary damage may also play important roles influencing long-term neuroinflammatory process one most influences on disease progression. Here, we summarize stroke, particular, how activates recruits components, review recent advances corresponding approaches clinical studies, emphasizing importance role

Language: Английский

Citations

18
A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomes DOI Creative Commons
Sarah Rewell,

Ali Shad,

Lingjun Chen

et al.

Experimental Neurology, Journal Year: 2025, Volume and Issue: 386, P. 115150 - 115150

Published: Jan. 20, 2025

Language: Английский

Citations

2
In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation DOI Creative Commons
Dan Zhang,

Yikun Ren,

Yuanmeng He

et al.

Materials Today Bio, Journal Year: 2022, Volume and Issue: 15, P. 100278 - 100278

Published: May 10, 2022

The efficacy of neural repair and regeneration strategies for traumatic brain injury (TBI) treatment is greatly hampered by the harsh lesion microenvironment including oxidative stress hyper-inflammatory response. Functionalized hydrogel with capability suppression neuroinflammation inhibition will contribute to repairment TBI. Herein, antioxidant gallic acid-grafted hyaluronic acid (HGA) was combined acid-tyramine (HT) polymer develop an injectable dual-enzymatically crosslinking method. resulting HT/HGA biocompatible possesses effective scavenging activity against DPPH hydroxyl radicals. Meanwhile, this improved cell viability reduced intracellular reactive oxygen species (ROS) production under H2O2 insult. in vivo study showed that situ injection significantly malondialdehyde (MDA) increased glutathione (GSH) expression area after 3 or 21 days, which might be associated activation Nrf2/HO-1 pathway. Furthermore, promoted microglia polarization M2 (Arg1) phenotype, it also decreased level proinflammatory factors TNF-α IL-6 anti-inflammatory factor IL-4. Finally, blood-brain barrier (BBB) protected, neurogenesis hippocampus promoted, motor, learning memory ability enhanced. Therefore, injectable, biocompatible, exhibits a huge potential treating TBI allows us recognize great value novel biomaterial remodeling structure function.

Language: Английский

Citations

59
MCC950 in the treatment of NLRP3-mediated inflammatory diseases: Latest evidence and therapeutic outcomes DOI

Saba Bakhshi,

Saeedeh Shamsi

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 106, P. 108595 - 108595

Published: Feb. 3, 2022

Language: Английский

Citations

54
Gastrointestinal Microbiome and Neurologic Injury DOI Creative Commons
Eric Panther,

William Dodd,

Alec Clark

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(2), P. 500 - 500

Published: Feb. 21, 2022

Communication between the enteric nervous system (ENS) of gastrointestinal (GI) tract and central (CNS) is vital for maintaining systemic homeostasis. Intrinsic extrinsic neurological inputs gut regulate blood flow, peristalsis, hormone release, immunological function. The health microbiome plays a role in regulating overall function well-being individual. Microbes release short-chain fatty acids (SCFAs) that G-protein-coupled receptors to mediate neurotransmitter (i.e., serotonin, dopamine, noradrenaline, γ-aminobutyric acid (GABA), acetylcholine, histamine), inflammation mood. Further gaseous factors nitric oxide) are important have response injury. Neurologic injuries such as ischemic stroke, spinal cord injury, traumatic brain hemorrhagic cerebrovascular lesions can all lead dysbiosis. Additionally, unfavorable alterations composition microbiota may be associated with increased risk these neurologic due proinflammatory molecules clotting factors. Interventions probiotics, fecal transplantation, oral SCFAs been shown stabilize improve microbiome. However, effect this has on injury prevention recovery not studied extensively. purpose review elaborate complex relationship report how modulates status Finally, we will propose various interventions beneficial from

Language: Английский

Citations

51
Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition DOI
Na Li, Ruijia Zhang, Minghai Tang

et al.

Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 66(21), P. 14447 - 14473

Published: Oct. 25, 2023

NLRP3 inflammasome is a multiprotein complex involved in host immune response─which exerts various biological effects by mediating the maturation and secretion of IL-1β IL-18─and pyroptosis. However, its aberrant activation could cause amplification inflammatory effects, thereby triggering range ailments, including Alzheimer's disease, Parkinson's rheumatoid arthritis, gout, type 2 diabetes mellitus, cancer. For past few years, as an attractive anti-inflammatory target, NLRP3-targeting small-molecule inhibitors have been widely reported both academic industrial communities. In order to deeply understand advancement inhibitors, we provide comprehensive insights commentary on drugs currently under clinical investigation, well other from chemical structure point view, with aim new for further development inflammasome-mediated diseases.

Language: Английский

Citations

41
Therapeutic Potential of Cannabis: A Comprehensive Review of Current and Future Applications DOI Creative Commons

Zach J. Leinen,

Rahul Mohan,

Lakmini S. Premadasa

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2630 - 2630

Published: Sept. 25, 2023

Historically, cannabis has been valued for its pain-relieving, anti-inflammatory, and calming properties. Ancient civilizations like the Egyptians, Greeks, Chinese medicines recognized their therapeutic potential. The discovery of endocannabinoid system, which interacts with phytoconstituents, scientifically explained how affects human immune including central nervous system (CNS). This review explores evolving world cannabis-based treatments, spotlighting diverse applications. By researching current research clinical studies, we probe into cannabinoids Δ9-tetrahydrocannabinol (THC) cannabidiol (CBD) help to manage conditions ranging from chronic pain, persistent inflammation, cancer, inflammatory bowel disease, neurological disorders even viral diseases such as Human Immunodeficiency virus (HIV), SARS-CoV-2. emerging monkeypox. long-term recreational use can develop disorder (CUD), therefore, understanding factors contributing development maintenance addiction, genetic predisposition, neurobiological mechanisms, environmental influences, will be timely. Shedding light on adverse impacts CUD underscores importance early intervention, effective treatment approaches, public health initiatives address this complex issue in an landscape policies perceptions.

Language: Английский

Citations

35
Neuroinflammation and Brain Disease DOI Creative Commons
Anna Bersano, Jürgen Engele,

M.K.E. Schäfer

et al.

BMC Neurology, Journal Year: 2023, Volume and Issue: 23(1)

Published: June 12, 2023

Abstract Starting from the perspective of an immune-privileged site, our knowledge inflammatory processes within central nervous system has increased rapidly over last 30 years, leading to a rather puzzling picture today. Of particular interest is emergence disease- and injury-specific responses brain, which may form basis for future therapeutic approaches. To advance this important topic, we invite authors contribute research clinical papers Collection “Neuroinflammation Brain Disease”.

Language: Английский

Citations

25