Biology,
Год журнала:
2023,
Номер
13(1), С. 21 - 21
Опубликована: Дек. 29, 2023
Traumatic
brain
injury
(TBI)
is
a
leading
cause
of
mortality
and
long-term
impairment
globally.
TBI
has
dynamic
pathology,
encompassing
variety
metabolic
molecular
events
that
occur
in
two
phases:
primary
secondary.
A
forceful
external
blow
to
the
initiates
phase,
followed
by
secondary
phase
involves
release
calcium
ions
(Ca2+)
initiation
cascade
inflammatory
processes,
including
mitochondrial
dysfunction,
rise
oxidative
stress,
activation
glial
cells,
damage
blood–brain
barrier
(BBB),
resulting
paracellular
leakage.
Currently,
there
are
no
FDA-approved
drugs
for
TBI,
but
existing
approaches
rely
on
delivering
micro-
macromolecular
treatments,
which
constrained
BBB,
poor
retention,
off-target
toxicity,
complex
pathology
TBI.
Therefore,
demand
innovative
alternative
therapeutics
with
effective
delivery
tactics
diagnosis
treatment
Tissue
engineering,
includes
use
biomaterials,
one
such
approach.
Biomaterials,
as
hydrogels,
self-assembling
peptides
electrospun
nanofibers,
can
be
used
alone
or
combination
neuronal
stem
cells
induce
neurite
outgrowth,
differentiation
human
neural
nerve
gap
bridging
This
review
examines
inclusion
biomaterials
potential
treatments
their
types,
synthesis,
mechanisms
action.
also
discusses
challenges
faced
development
biodegradable,
biocompatible,
mechanically
flexible
and,
if
combined
survival
rate
transplanted
cells.
better
understanding
drawbacks
these
novel
therapeutic
will
help
guide
design
future
therapies.
Journal of Hematology & Oncology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Ноя. 30, 2023
Inflammation
is
a
fundamental
defensive
response
to
harmful
stimuli,
but
the
overactivation
of
inflammatory
responses
associated
with
most
human
diseases.
Reactive
oxygen
species
(ROS)
are
class
chemicals
that
generated
after
incomplete
reduction
molecular
oxygen.
At
moderate
levels,
ROS
function
as
critical
signaling
molecules
in
modulation
various
physiological
functions,
including
responses.
However,
at
excessive
exert
toxic
effects
and
directly
oxidize
biological
macromolecules,
such
proteins,
nucleic
acids
lipids,
further
exacerbating
development
causing
Therefore,
designing
manufacturing
biomaterials
scavenge
has
emerged
an
important
approach
for
restoring
homeostasis,
limiting
protecting
host
against
damage.
This
review
systematically
outlines
dynamic
balance
production
clearance
under
conditions.
We
focus
on
mechanisms
by
which
regulate
cell
proteins
how
these
affect
inflammation.
Furthermore,
we
discuss
use
potential
currently
available-biomaterials
ROS,
agents
were
engineered
reduce
levels
blocking
generation,
chemically
reacting
or
catalytically
accelerating
clearance,
treatment
Finally,
evaluate
challenges
prospects
controlled
material
design
scavenging
biomaterials.
Materials Today Bio,
Год журнала:
2023,
Номер
20, С. 100614 - 100614
Опубликована: Март 22, 2023
Repairing
central
nervous
system
(CNS)
is
difficult
due
to
the
inability
of
neurons
recover
after
damage.
A
clinically
acceptable
treatment
promote
CNS
functional
recovery
and
regeneration
currently
unavailable.
According
recent
studies,
injectable
hydrogels
as
biodegradable
scaffolds
for
tissue
engineering
have
exceptionally
desirable
attributes.
Hydrogel
has
a
biomimetic
structure
similar
extracellular
matrix,
hence
been
considered
3D
scaffold
regeneration.
An
interesting
new
type
hydrogel,
hydrogels,
can
be
injected
into
target
areas
with
little
invasiveness
imitate
several
aspects
CNS.
Injectable
are
being
researched
therapeutic
agents
because
they
may
numerous
properties
tissues
reduce
subsequent
injury
regenerate
neural
tissue.
Because
their
less
adverse
effects
cost,
easier
use
implantation
pain,
faster
capacity,
more
than
non-injectable
hydrogels.
This
article
discusses
pathophysiology
kinds
brain
spinal
cord
engineering,
paying
particular
emphasis
experimental
studies.
Polymers,
Год журнала:
2023,
Номер
15(10), С. 2373 - 2373
Опубликована: Май 19, 2023
The
prevention
of
disease
and
infection
requires
immune
systems
that
operate
effectively.
This
is
accomplished
by
the
elimination
infections
abnormal
cells.
Immune
or
biological
therapy
treats
either
stimulating
inhibiting
system,
dependent
upon
circumstances.
In
plants,
animals,
microbes,
polysaccharides
are
abundant
biomacromolecules.
Due
to
intricacy
their
structure,
may
interact
with
impact
response;
hence,
they
play
a
crucial
role
in
treatment
several
human
illnesses.
There
an
urgent
need
for
identification
natural
biomolecules
prevent
treat
chronic
disease.
article
addresses
some
naturally
occurring
known
therapeutic
potential
have
already
been
identified.
also
discusses
extraction
methods
immunological
modulatory
capabilities.
Abstract
Deregulated
inflammations
induced
by
various
factors
are
one
of
the
most
common
diseases
in
people's
daily
life,
while
severe
inflammation
can
even
lead
to
death.
Thus,
efficient
treatment
has
always
been
hot
topic
research
medicine.
In
past
decades,
as
a
potential
biomaterial,
stimuli‐responsive
hydrogels
have
focus
attention
for
due
their
excellent
biocompatibility
and
design
flexibility.
Recently,
thanks
rapid
development
nanotechnology
material
science,
more
efforts
made
develop
safer,
personal
effective
therapy
some
frequent
but
tough
such
sepsis,
rheumatoid
arthritis,
osteoarthritis,
periodontitis,
ulcerative
colitis.
Herein,
from
recent
studies
articles,
conventional
emerging
delivery
anti‐inflammatory
drugs
summarized.
And
prospects
clinical
translation
future
also
discussed
further
detail.
Biomaterials Science,
Год журнала:
2024,
Номер
12(6), С. 1405 - 1424
Опубликована: Янв. 1, 2024
This
review
introduces
gallic-acid
hydrogels,
covering
their
crosslinking
mechanisms,
physicochemical
properties,
synthesis
methods,
and
biomedical
applications,
aiming
to
provide
inspiration
for
the
design
of
multifunctional
polyphenol
hydrogels.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 6, 2025
Traumatic
brain
injury
(TBI)
represents
a
significant
global
public
health
issue,
with
effective
management
posing
numerous
challenges.
The
pathophysiology
of
TBI
is
typically
categorized
into
two
phases:
primary
and
secondary
injuries.
Secondary
involves
pathophysiological
mechanisms
such
as
blood-brain
barrier
(BBB)
disruption,
mitochondrial
dysfunction,
oxidative
stress,
inflammatory
responses.
Current
pharmacological
strategies
often
encounter
obstacles
in
treating
effectively,
primarily
due
to
challenges
BBB
penetration,
inadequate
target
site
accumulation,
off-target
toxicity.
Versatile
hydrogels
nanoparticles
offer
potential
solutions
these
limitations.
This
review
discusses
recent
progress
utilizing
for
treatment
over
the
past
5
years,
highlighting
their
relevance
underlying
pathophysiology.
Hydrogels
demonstrate
substantial
promise
addressing
injury,
providing
broad
spectrum
future
therapeutic
opportunities.
