Meta-hallmarks of aging and cancer

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(1), P. 12 - 35

Published: Jan. 1, 2023

Language: Английский

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Chronic inflammation and the hallmarks of aging

Molecular Metabolism, Journal Year: 2023, Volume and Issue: 74, P. 101755 - 101755

Published: June 16, 2023

Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, low-grade inflammation during aging, without overt infection, is defined as "inflammaging," which associated with increased morbidity mortality in population. Emerging evidence suggests a bidirectional cyclical relationship between development age-related conditions, such cardiovascular diseases, neurodegeneration, cancer, frailty. How crosstalk other underlies biological mechanisms disease thus particular interest current geroscience research.

Language: Английский

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SenNet recommendations for detecting senescent cells in different tissues

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(12), P. 1001 - 1023

Published: June 3, 2024

Language: Английский

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Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 13, 2023

Abstract Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as capacity preserve and/or rapidly restore functions that promote disease resistance (immunocompetence) and control inflammation infectious diseases well other causes of inflammatory stress. We gauge IR levels with two distinct peripheral blood metrics quantify balance between (i) CD8 + CD4 T-cell (ii) gene expression signatures tracking longevity-associated immunocompetence mortality-associated inflammation. Profiles ~48,500 individuals collectively indicate some persons resist degradation both during aging when challenged varied stressors. With resistance, preservation tracked a lower risk HIV acquisition, AIDS development, symptomatic influenza infection, recurrent skin cancer; survival COVID-19 sepsis; (iii) longevity. potentially reversible by decreasing Overall, show trait observed across age spectrum, more common females, aligned specific immunocompetence-inflammation linked favorable immunity-dependent health outcomes. mechanisms have utility biomarkers for measuring improving

Language: Английский

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The role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap

Molecular Neurodegeneration, Journal Year: 2023, Volume and Issue: 18(1)

Published: June 5, 2023

Abstract Peripheral inflammation, defined as inflammation that occurs outside the central nervous system, is an age-related phenomenon has been identified a risk factor for Alzheimer’s disease. While role of chronic peripheral well characterized in context dementia and other conditions, less known about neurologic contribution acute inflammatory insults take place system. Herein, we define immune challenge form pathogen exposure (e.g., viral infection) or tissue damage surgery) causes large, yet time-limited, response. We provide overview clinical translational research examined connection between disease, focusing on three categories have received considerable attention recent years: infection, critical illness, surgery. Additionally, review neurobiological mechanisms which facilitate neural response to discuss potential blood–brain barrier components neuro-immune axis After highlighting knowledge gaps this area research, propose roadmap address methodological challenges, suboptimal study design, paucity transdisciplinary efforts thus far limited our understanding how pathogen- damage-mediated may contribute Finally, therapeutic approaches designed promote resolution be used following preserve brain health limit progression neurodegenerative pathology.

Language: Английский

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Aging and Inflammation

Cold Spring Harbor Perspectives in Medicine, Journal Year: 2023, Volume and Issue: 14(6), P. a041197 - a041197

Published: Dec. 5, 2023

Amit Singh1,6, Shepherd H. Schurman2,6, Arsun Bektas3, Mary Kaileh1, Roshni Roy1,5, David M. Wilson III4, Ranjan Sen1 and Luigi Ferrucci3 1Laboratory of Molecular Biology Immunology, National Institute on Aging, Baltimore, Maryland 21224, USA 2Clinical Research Unit, 3Translational Gerontology Branch, 4Biomedical Institute, Hasselt University, Diepenbeek 3500, Belgium Correspondence: ferruccilu{at}grc.nia.nih.gov ↵6 These authors contributed equally to this work. ↵5 Present address: Department Microbiology Emory University School Medicine, Atlanta, Georgia 30322, USA.

Language: Английский

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Bioinformatics analysis of shared biomarkers and immune pathways of preeclampsia and periodontitis

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 27, 2025

Epidemiological evidence indicates that preeclampsia (PE) is associated with comorbidities such as periodontitis (PD). However, the underlying mechanism remains unclear. To enhance our understanding of their co-pathogenesis, this research investigated shared biomarkers and pathological mechanisms. We systematically retrieved transcriptomic datasets from Gene Expression Omnibus database. These encompass a comparative analysis periodontium without PD placenta PE. Differentially Expressed Genes Analysis Weighted Go-expression Network (WGCNA) were used to identify key crosstalk genes in patients The functional characterisation these was performed using enrichment analysis. Protein–protein interaction networks machine learning methods leveraged hub genes. XG-Boost algorithm applied construct diagnostic models gain insight into disease aetiology. identified validated by single-cell RNA sequencing ensure robustness biological relevance. A total 55 identified, which primarily enriched immune-related pathways limma WGCNA. Among them, twenty-four protein–protein methods. model constructed outperformed other two (area under receiver operating characteristic curve [ROC] = 0.7786 0.7454 for PE PD, respectively). Pathways involving mapped Kyoto Encyclopedia Genomes In addition, showed expression BIN2, LYN, PIK3AP1, NEDD9 neutrophils significantly downregulated, LYN fibroblasts endothelial cells consistently upregulated. Shared immunologic characterised between NEDD9, suggesting pathogenesis could pave way development effective diagnostic, treatment, management strategies.

Language: Английский

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Physiological Concentrations of Calciprotein Particles Trigger Activation and Pro-Inflammatory Response in Endothelial Cells and Monocytes

Biochemistry (Moscow), Journal Year: 2025, Volume and Issue: 90(1), P. 132 - 160

Published: Jan. 1, 2025

Language: Английский

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The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging

Aging Cell, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

ABSTRACT Human aging presents an evolutionary paradox: while rates remain constant, healthspan and lifespan vary widely. We address this conundrum via salutogenesis—the active production of health—through immune resilience (IR), the capacity to resist disease despite inflammation. Analyzing ~17,500 individuals across stages inflammatory challenges, we identified a core salutogenic mechanism: IR centered on TCF7 , conserved transcription factor maintaining T‐cell stemness regenerative potential. integrates innate adaptive immunity counter three mortality drivers: chronic inflammation (inflammaging), aging, cellular senescence. By mitigating these mechanisms, confers survival advantages: At age 40, with poor face 9.7‐fold higher rate—a risk equivalent that 55.5‐year‐olds optimal IR—resulting in 15.5‐year gap survival. Optimal preserves youthful profiles at any age, enhances vaccine responses, reduces burdens cardiovascular disease, Alzheimer's, serious infections. Two key themes emerge: first, female‐predominant IR, including likely reflects pressures favoring reproductive success caregiving; second, midlife (40–70 years) is critical window where by 69%. After 70, converge between resilient non‐resilient groups, reflecting biological limits longevity extension. TNFα‐blockers restore salutogenesis pathways, indicating delays aging‐related processes rather than altering rates. reframing as salutogenic‐pathogenic balance, establish ‐centered central healthy longevity. Targeted interventions enhance offer actionable strategies maximize before constraints limit benefits.

Language: Английский

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An Integrated Multi-Omics and Artificial Intelligence Framework for Advance Plant Phenotyping in Horticulture

Biology, Journal Year: 2023, Volume and Issue: 12(10), P. 1298 - 1298

Published: Sept. 30, 2023

This review discusses the transformative potential of integrating multi-omics data and artificial intelligence (AI) in advancing horticultural research, specifically plant phenotyping. The traditional methods phenotyping, while valuable, are limited their ability to capture complexity biology. advent (meta-)genomics, (meta-)transcriptomics, proteomics, metabolomics has provided an opportunity for a more comprehensive analysis. AI machine learning (ML) techniques can effectively handle volume data, providing meaningful interpretations predictions. Reflecting multidisciplinary nature this area review, readers will find collection state-of-the-art solutions that key integration phenotyping experiments horticulture, including experimental design considerations with several technical non-technical challenges, which discussed along solutions. future prospects include precision predictive breeding, improved disease stress response management, sustainable crop exploration biodiversity. holds immense promise revolutionizing research applications, heralding new era

Language: Английский

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