European journal of psychotraumatology,
Год журнала:
2012,
Номер
3(1)
Опубликована: Апрель 27, 2012
This
paper
outlines
the
state
of
affairs
in
psychobiological
research
on
psychotrauma
and
PTSD
with
a
focus
role
oxytocin
system
traumatic
stress.
With
high
prevalence
trauma
Netherlands,
new
preventive
therapeutic
interventions
are
needed.
The
is
social
support
bonding
coming
to
grips
psychological
trauma,
about
as
basis
for
reducing
stress
response
creating
feeling
bonding,
binding
words
painful
emotions
psychotherapy,
bonds
between
researchers
clinicians.
American Journal of Psychiatry,
Год журнала:
2014,
Номер
171(8), С. 872 - 880
Опубликована: Май 16, 2014
Differential
effects
of
maternal
and
paternal
posttraumatic
stress
disorder
(PTSD)
have
been
observed
in
adult
offspring
Holocaust
survivors
both
glucocorticoid
receptor
sensitivity
vulnerability
to
psychiatric
disorder.
The
authors
examined
the
relative
influences
PTSD
on
DNA
methylation
exon
1F
promoter
(GR-1F)
gene
(NR3C1)
peripheral
blood
mononuclear
cells
its
relationship
offspring.Adult
with
at
least
one
survivor
parent
(N=80)
demographically
similar
participants
without
parental
exposure
or
(N=15)
completed
clinical
interviews,
self-report
measures,
biological
procedures.
Blood
samples
were
collected
for
analysis
GR-1F
cortisol
levels
response
low-dose
dexamethasone,
two-way
covariance
was
performed
using
as
main
effects.
Hierarchical
clustering
used
permit
visualization
compared
variables
methylation.A
significant
interaction
demonstrated
that
absence
PTSD,
showed
higher
methylation,
whereas
lower
methylation.
Lower
significantly
associated
greater
postdexamethasone
suppression.
revealed
differentially
indicators
methylation.This
is
first
study
demonstrate
alterations
relation
neuroendocrine
outcomes.
moderation
by
suggests
different
mechanisms
intergenerational
transmission
trauma-related
vulnerabilities.
Frontiers in Psychiatry,
Год журнала:
2013,
Номер
4
Опубликована: Янв. 1, 2013
Epigenetic
alterations
offer
promise
as
prognostic
or
diagnostic
markers,
but
it
is
not
known
whether
these
measures
associate
with,
predict,
clinical
state.
These
questions
were
addressed
in
a
pilot
study
with
combat
veterans
PTSD
to
determine
cytosine
methylation
promoter
regions
of
the
glucocorticoid
related
NR3C1
and
FKBP51
genes
would
predict
treatment
outcome.
Veterans
received
prolonged
exposure
(PE)
psychotherapy,
yielding
responders
(n=8),
defined
by
no
longer
meeting
criteria
for
PTSD,
non-responders
(n=8).
Blood
samples
obtained
at
pre-treatment,
after
12
weeks
psychotherapy
(post-treatment),
3
month
follow-up.
Methylation
was
examined
DNA
extracted
from
lymphocytes.
Measures
reflecting
receptor
(GR)
activity
also
lymphocytes
(i.e.,
plasma
24h-urinary
cortisol,
ACTH,
lysozyme
IC50-DEX,
neuropetide-Y).
GR
gene
(NR3C1)
exon
1F
assessed
pre-treatment
predicted
outcome,
significantly
altered
post-treatment
In
contrast,
FKBP5
(FKBP51)
1
region
did
response,
decreased
association
recovery.
subset,
corresponding
group
difference
expression
observed,
showing
higher
than
non-responders.
Endocrine
markers
changed
symptom
change.
preliminary
observations
require
replication
validation.
However,
results
support
research
indicating
that
some
are
subject
environmental
regulation
throughout
life.
Moreover,
constitutes
form
'environmental
regulation'
may
alter
epigenetic
Finally,
further
suggest
different
be
associated
prognosis
state,
respec
The
central
theme
of
personalized
medicine
is
the
premise
that
an
individual's
unique
physiologic
characteristics
play
a
significant
role
in
both
disease
vulnerability
and
response
to
specific
therapies.
major
goals
are
therefore
predict
susceptibility
developing
illness,
achieve
accurate
diagnosis,
optimize
most
efficient
favorable
treatment.
goal
achieving
psychiatry
laudable
one,
because
its
attainment
should
be
associated
with
marked
reduction
morbidity
mortality.
In
this
review,
we
summarize
illustrative
selection
studies
laying
foundation
towards
personalizing
depressive
disorder,
bipolar
schizophrenia.
addition,
present
emerging
applications
likely
advance
psychiatry,
emphasis
on
novel
biomarkers
neuroimaging.
