Deleted Journal, Год журнала: 2025, Номер unknown, С. 100095 - 100095
Опубликована: Янв. 1, 2025
Язык: Английский
JAMA Psychiatry, Год журнала: 2024, Номер 81(6), С. 586 - 586
Опубликована: Март 6, 2024
Exposure to adverse childhood experiences (ACEs) has consistently been associated with multiple negative mental health outcomes extending into adulthood. However, given that ACEs and psychiatric disorders cluster within families, it remains be comprehensively assessed what extent familial confounding contributes associations between clinically confirmed adult disorders.
Язык: Английский
Процитировано
75
JAMA Psychiatry, Год журнала: 2024, Номер 81(8), С. 769 - 769
Опубликована: Май 1, 2024
Importance Prospective and retrospective measures of childhood maltreatment identify largely different groups individuals. However, it is unclear if these are differentially associated with psychopathology. Objective To analyze the associations prospective Data Sources Based on a preregistered protocol, Embase, PsycInfo, MEDLINE were searched for peer-reviewed studies published by January 1, 2023, that measured child Study Selection Titles abstracts all articles captured search full texts potentially eligible independently screened 2 authors. Observational association psychopathology included. Extraction Synthesis Multiple investigators extracted data. Multilevel random-effects meta-analyses used to pool results test predictors heterogeneity. Main Outcome Measures Associations between or psychopathology, both unadjusted adjusted (ie, measures, vice versa), moderation preselected variables. Results The based 24 including 15 485 individuals (51.0% female; mean age, 21.3 years at report). Retrospective showed stronger relative in analyses (retrospective measures: odds ratio [OR], 2.21; 95%, 1.94-2.42 vs OR, 1.56; 95% CI, 1.39-1.76) 2.14; 1.90-2.42 1.27; 1.13-1.41). There was no statistically significant when assessment self-reports focused internalizing emotional disorders. Conclusions Relevance Psychopathology more strongly measures—which capture first-person, subjective appraisal events reflected memory recall—compared essentially third-person accounts such events. Maltreatment-related may be driven interpretations experiences, distressing memories, schemas, which could targeted cognitive interventions.
Язык: Английский
Процитировано
37
JAMA Psychiatry, Год журнала: 2024, Номер 81(8), С. 782 - 782
Опубликована: Май 8, 2024
The proportion of mental disorders and burden causally attributable to childhood maltreatment is unknown.
Язык: Английский
Процитировано
26
International Journal of Epidemiology, Год журнала: 2022, Номер 52(1), С. 227 - 249
Опубликована: Июль 28, 2022
Abstract Background The use of Mendelian randomization (MR) in epidemiology has increased considerably recent years, with a subsequent increase systematic reviews MR studies. We conducted review tools designed for assessing risk bias and/or quality evidence studies and Methods systematically searched MEDLINE, Embase, the Web Science, preprints servers Google Scholar articles containing assessing, conducting reporting also protocols From eligible we collected data on tool characteristics content, as well details narrative description assessment. Results Our searches retrieved 2464 records to screen, from which 14 tools, 35 38 were included our review. Seven bias/quality evaluation their content revealed that all seven addressed three core assumptions instrumental variable analysis, violation can potentially introduce analysis estimates. Conclusion present an overview methods assess analysis. Issues commonly relate standard variables analyses, choice genetic instrument(s) features population(s) are (particularly two-sample MR), addition more traditional non-MR-specific epidemiological biases. identified should be tested validated general before recommendations made widespread use. findings raise awareness about importance related provide information is useful assessment context reviews.
Язык: Английский
Процитировано
54
Nature Human Behaviour, Год журнала: 2022, Номер 7(2), С. 269 - 290
Опубликована: Дек. 8, 2022
Язык: Английский
Процитировано
46
JAMA Network Open, Год журнала: 2023, Номер 6(11), С. e2340018 - e2340018
Опубликована: Ноя. 1, 2023
Importance Adverse life experiences have been proposed to contribute diverse mental health problems through an association with corticolimbic functioning. Despite compelling evidence from animal models, findings studies in humans mixed; activation likelihood estimation (ALE) meta-analyses failed identify a consistent of adverse events brain function. Objective To investigate the adversity exposure altered reactivity using multilevel kernel density analyses (MKDA), meta-analytic approach considered more robust than ALE small sample sizes and methodological differences between studies. Data Sources Searches were conducted PsycInfo, Medline, EMBASE, Web Science inception May 4, 2022. The following search term combinations used for each database: trauma , posttraumatic stress disorder ( PTSD ), abuse maltreatment poverty or ; functional magnetic resonance imaging fMRI ) neuroimaging; emotion regulation memory processing inhibitory control executive functioning reward . Study Selection Task-based within 4 domains (emotion processing, control, processing) that included measure whole-brain coordinate results reported Talairach Montreal Neurological Institute space included. Conference abstracts, books, reviews, meta-analyses, opinions, studies, articles not English, fewer 5 participants excluded. Extraction Synthesis Using Preferred Reporting Items Systematic Reviews Meta-Analyses reporting guideline, 2 independent reviewers assessed abstracts full-text entry criteria. A third reviewer resolved conflicts errors data extraction. pooled random-effects model analysis occurred August November Main Outcomes Measures Peak x-axis (left-right), y-axis (posterior-anterior), z-axis (inferior-superior) coordinates extracted all submitted MKDA meta-analyses. Results total 83 meta-analysis, yielding combined 5242 801 coordinates. Adversity was associated higher amygdala (familywise error rate corrected at P < .001; = 22; −4; −17) lower prefrontal cortical 10; 60; 10) across range task domains. These responses only observed adult clearest among those who had exposed severe threat trauma. Conclusions Relevance In this meta-analysis function, prior challenges. might better how diminishes ability cope later stressors produces enduring susceptibility problems.
Язык: Английский
Процитировано
32
Development and Psychopathology, Год журнала: 2024, Номер unknown, С. 1 - 16
Опубликована: Март 6, 2024
Abstract Developmental psychopathology started as an intersection of fields and is now a field itself. As we contemplate the future this field, consider ways in which newer, interdisciplinary – human developmental neuroscience can inform, be informed by, psychopathology. To do so, outline principles how they are and/or implemented neuroscience. In turn, highlight collaboration between these lead to richer models more impactful translation. doing describe from enrich directions for
Язык: Английский
Процитировано
10
Acta Psychiatrica Scandinavica, Год журнала: 2025, Номер unknown
Опубликована: Март 3, 2025
ABSTRACT Introduction Childhood maltreatment (CM) and depression are serious global issues with high prevalence lifelong impacts on physical mental health. CM has been proposed as a modifiable risk factor for that, if prevented, may contribute to reduction in the incidence of depressive disorders. Despite this, there is paucity reviews examining strength association between these variables. The aim this systematic review meta‐analysis was evaluate empirical evidence determine supported preventable depression. Methods A search performed July 2024 all peer‐reviewed journal articles written English relationship adult electronic databases EBSCOhost , Proquest Embase . Studies were included they measured before 18 years age independent variable dependent variable. excluded outcome grouped comorbidity did not report primary quantitative data. total 77 studies 516,302 participants met inclusion criteria review. Results random‐effects used generate pooled odds ratio from 87 effect estimates demonstrated that individuals history any 2.5 times more likely experience ( OR = 2.49 [95% CI: 2.25–2.76]). This increase remained regardless how screened Conclusions These findings confirmed strong High heterogeneity meta‐analytic results also suggested further research required applies consistent adjustments comorbidities confounding factors examines temporal variables establish causality.
Язык: Английский
Процитировано
1
American Journal of Psychiatry, Год журнала: 2025, Номер 182(4), С. 360 - 372
Опубликована: Апрель 1, 2025
Estimating the current association between childhood adversity and risk of psychosis is crucial for prevention intervention. We provided an updated synthesis evidence from past four decades, expanded available data by investigating a broad array subtypes, explored sex differences age onset as relevant factors. searched PubMed, EMBASE, PsycINFO, Web Science, WANFANG, CNKI, case-control, cross-sectional cohort studies on psychotic symptoms/illness. Multi-level meta-analysis, prediction intervals calculation, sensitivity analyses were conducted. The main analysis included 183 study samples (N=349,265), with 119 case-control (15,186 cases; 14,879 controls), 51 (N=299,659), 13 (N=19,541). Significant associations observed across all designs, yielding overall odds ratio 2.80 (95% CI=2.18, 3.60). Secondary revealed that exposure to each subtype increased psychosis, highest (3.54 [95% CI=3.04, 4.13]) emotional abuse, lowest (1.58 CI=1.48, 1.68]) parental antipathy. No statistically significant observed, although sexual abuse was higher women. Onset earlier in adversity-exposed individuals (mean difference=-0.79 years, 95% CI=-1.47 -0.12). This largest meta-analysis date psychosis. results have clinical implications, they highlight need selective early adversities implementation trauma-informed therapies treatment
Язык: Английский
Процитировано
1
Nature Human Behaviour, Год журнала: 2025, Номер unknown
Опубликована: Апрель 10, 2025
Язык: Английский
Процитировано
1