Microbial Turnover of Glyphosate to Biomass: Utilization as Nutrient Source and Formation of AMPA and Biogenic NER in an OECD 308 Test DOI
Andreas Libonati Brock, Arno Rein, Fabio Polesel

и другие.

Environmental Science & Technology, Год журнала: 2019, Номер 53(10), С. 5838 - 5847

Опубликована: Апрель 17, 2019

Environmental fate assessment of chemicals involves standardized simulation tests with isotope-labeled molecules to balance transformation, mineralization, and formation nonextractable residues (NER). Methods predict microbial turnover biogenic NER have been developed, having limited use when metabolites accumulate, the are not only C source, or provide for other macroelements. To improve predictive capability, we extended a recently developed method growth yield estimation account incomplete degradation multiple-element assimilation combined it dynamic model description in soils sediments. We evaluated results against unique experimental data 13C3-15N co-labeled glyphosate AMPA water-sediment systems (OECD 308). Balancing 13C- 15N- fluxes biomass showed pronounced shift transformation from full mineralization formation. This may be explained by various hypotheses, example, substrate inherent batch conditions test system causing starvation inhibition P release. Modeling indicate initial N overload due lower C/N ratio compared average cell composition leading subsequent demand accumulation AMPA.

Язык: Английский

Environmental fate and effects assessment of human pharmaceuticals: lessons learnt from regulatory data DOI Creative Commons
Simon Schwarz, Daniela Gildemeister, A. Hein

и другие.

Environmental Sciences Europe, Год журнала: 2021, Номер 33(1)

Опубликована: Июнь 2, 2021

Abstract Human pharmaceuticals are extensively studied and assessed before marketing approval. Since 2006, this also includes an assessment of environmental risks. In the European Union, is based on guideline risk medicinal products for human use (EMEA/CHMP/SWP/4447/00 corr 2), which currently under revision. For Germany, German Environment Agency (UBA) tasked with evaluation risks pharmaceuticals. Applicants seeking approval need to submit fate effect data, in case predicted concentrations (PECs) exceed 10 ng/L surface waters, or substance specific concern through its mode action physico-chemical characteristics. Over last decade, regulatory work resulted internal agency database containing data approximately 300 active pharmaceutical ingredients (APIs). A considerable part not publicly available due property rights held by respective applicants. The was evaluated draw conclusions how current approach may be improved. aquatic shows variation ecotoxic concentrations, but supports as PEC limit. endocrine-active substances antibiotics, a clear sensitivity profile observed, allows more targeted future. drawn from terrestrial less clear, itself biased because information only high sorption. Further adaptations strategy, including triggers, appear necessary. Fate show persistence many APIs: 43% all APIs classified very persistent; 12% these DT 50 values range where abiotic biotic degradation expected. Overall, has shown that improvements possible.

Язык: Английский

Процитировано

25
A novel passive sampling and sequential extraction approach to investigate desorption kinetics of emerging organic contaminants at the sediment−water interface DOI
Xiaowen Ji, Jonathan K. Challis,

Jenna Cantin

и другие.

Water Research, Год журнала: 2022, Номер 217, С. 118455 - 118455

Опубликована: Апрель 12, 2022

Язык: Английский

Процитировано

17
The effect of farming techniques on degradation of DDT in historical cotton farms DOI
Kathryn J. Barr, Parinya Panuwet, Eri Saikawa

и другие.

Environmental Pollution, Год журнала: 2024, Номер 351, С. 123961 - 123961

Опубликована: Апрель 11, 2024

Язык: Английский

Процитировано

3
Hydrogen isotope labeling unravels origin of soil-bound organic contaminant residues in biodegradability testing DOI Creative Commons
Sophie Lennartz,

Harriet A. Byrne,

Steffen Kümmel

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 24, 2024

Biodegradability testing in soil helps to identify safe synthetic organic chemicals but is still obscured by the formation of soil-bound 'non-extractable' residues (NERs). Present-day methodologies using radiocarbon or stable (

Язык: Английский

Процитировано

3
Microbial Turnover of Glyphosate to Biomass: Utilization as Nutrient Source and Formation of AMPA and Biogenic NER in an OECD 308 Test DOI
Andreas Libonati Brock, Arno Rein, Fabio Polesel

и другие.

Environmental Science & Technology, Год журнала: 2019, Номер 53(10), С. 5838 - 5847

Опубликована: Апрель 17, 2019

Environmental fate assessment of chemicals involves standardized simulation tests with isotope-labeled molecules to balance transformation, mineralization, and formation nonextractable residues (NER). Methods predict microbial turnover biogenic NER have been developed, having limited use when metabolites accumulate, the are not only C source, or provide for other macroelements. To improve predictive capability, we extended a recently developed method growth yield estimation account incomplete degradation multiple-element assimilation combined it dynamic model description in soils sediments. We evaluated results against unique experimental data 13C3-15N co-labeled glyphosate AMPA water-sediment systems (OECD 308). Balancing 13C- 15N- fluxes biomass showed pronounced shift transformation from full mineralization formation. This may be explained by various hypotheses, example, substrate inherent batch conditions test system causing starvation inhibition P release. Modeling indicate initial N overload due lower C/N ratio compared average cell composition leading subsequent demand accumulation AMPA.

Язык: Английский

Процитировано

27