Environmental Science & Technology,
Journal Year:
2019,
Volume and Issue:
53(10), P. 5838 - 5847
Published: April 17, 2019
Environmental
fate
assessment
of
chemicals
involves
standardized
simulation
tests
with
isotope-labeled
molecules
to
balance
transformation,
mineralization,
and
formation
nonextractable
residues
(NER).
Methods
predict
microbial
turnover
biogenic
NER
have
been
developed,
having
limited
use
when
metabolites
accumulate,
the
are
not
only
C
source,
or
provide
for
other
macroelements.
To
improve
predictive
capability,
we
extended
a
recently
developed
method
growth
yield
estimation
account
incomplete
degradation
multiple-element
assimilation
combined
it
dynamic
model
description
in
soils
sediments.
We
evaluated
results
against
unique
experimental
data
13C3-15N
co-labeled
glyphosate
AMPA
water-sediment
systems
(OECD
308).
Balancing
13C-
15N-
fluxes
biomass
showed
pronounced
shift
transformation
from
full
mineralization
formation.
This
may
be
explained
by
various
hypotheses,
example,
substrate
inherent
batch
conditions
test
system
causing
starvation
inhibition
P
release.
Modeling
indicate
initial
N
overload
due
lower
C/N
ratio
compared
average
cell
composition
leading
subsequent
demand
accumulation
AMPA.
Environmental Sciences Europe,
Journal Year:
2021,
Volume and Issue:
33(1)
Published: June 2, 2021
Abstract
Human
pharmaceuticals
are
extensively
studied
and
assessed
before
marketing
approval.
Since
2006,
this
also
includes
an
assessment
of
environmental
risks.
In
the
European
Union,
is
based
on
guideline
risk
medicinal
products
for
human
use
(EMEA/CHMP/SWP/4447/00
corr
2),
which
currently
under
revision.
For
Germany,
German
Environment
Agency
(UBA)
tasked
with
evaluation
risks
pharmaceuticals.
Applicants
seeking
approval
need
to
submit
fate
effect
data,
in
case
predicted
concentrations
(PECs)
exceed
10
ng/L
surface
waters,
or
substance
specific
concern
through
its
mode
action
physico-chemical
characteristics.
Over
last
decade,
regulatory
work
resulted
internal
agency
database
containing
data
approximately
300
active
pharmaceutical
ingredients
(APIs).
A
considerable
part
not
publicly
available
due
property
rights
held
by
respective
applicants.
The
was
evaluated
draw
conclusions
how
current
approach
may
be
improved.
aquatic
shows
variation
ecotoxic
concentrations,
but
supports
as
PEC
limit.
endocrine-active
substances
antibiotics,
a
clear
sensitivity
profile
observed,
allows
more
targeted
future.
drawn
from
terrestrial
less
clear,
itself
biased
because
information
only
high
sorption.
Further
adaptations
strategy,
including
triggers,
appear
necessary.
Fate
show
persistence
many
APIs:
43%
all
APIs
classified
very
persistent;
12%
these
DT
50
values
range
where
abiotic
biotic
degradation
expected.
Overall,
has
shown
that
improvements
possible.
Environmental Science & Technology,
Journal Year:
2019,
Volume and Issue:
53(10), P. 5838 - 5847
Published: April 17, 2019
Environmental
fate
assessment
of
chemicals
involves
standardized
simulation
tests
with
isotope-labeled
molecules
to
balance
transformation,
mineralization,
and
formation
nonextractable
residues
(NER).
Methods
predict
microbial
turnover
biogenic
NER
have
been
developed,
having
limited
use
when
metabolites
accumulate,
the
are
not
only
C
source,
or
provide
for
other
macroelements.
To
improve
predictive
capability,
we
extended
a
recently
developed
method
growth
yield
estimation
account
incomplete
degradation
multiple-element
assimilation
combined
it
dynamic
model
description
in
soils
sediments.
We
evaluated
results
against
unique
experimental
data
13C3-15N
co-labeled
glyphosate
AMPA
water-sediment
systems
(OECD
308).
Balancing
13C-
15N-
fluxes
biomass
showed
pronounced
shift
transformation
from
full
mineralization
formation.
This
may
be
explained
by
various
hypotheses,
example,
substrate
inherent
batch
conditions
test
system
causing
starvation
inhibition
P
release.
Modeling
indicate
initial
N
overload
due
lower
C/N
ratio
compared
average
cell
composition
leading
subsequent
demand
accumulation
AMPA.
