Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

Age-related diseases have emerged as a global concern the population ages. Consequently, understanding underlying causes of aging and exploring potential anti-aging interventions is imperative. In females, ovaries serve principal organs responsible for ovulation production female hormones. The are related to infertility, menopause, associated menopausal syndromes, with menopause representing culmination ovarian aging. Current evidence indicates that may contribute dysfunction across multiple organ systems, including, but not limited to, cognitive impairment, osteoporosis, cardiovascular disease. Nevertheless, due widespread distribution sex hormone receptors throughout body, affects only these specific also influences broader spectrum age-related in women. Despite this, impact on overall has been largely neglected. This review provides thorough summary diseases, encompassing nervous, circulatory, locomotor, urinary, digestive, respiratory, endocrine systems. Additionally, we outlined prospective therapeutic approaches addressing both aim mitigating their impacts preserving women's fertility, physical health, psychological well-being.

Язык: Английский

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Vitamin C: Its Role in Cosmeceuticals

Dermatological Reviews, Год журнала: 2025, Номер 6(1)

Опубликована: Янв. 14, 2025

ABSTRACT Background Vitamin C is a well‐known product used in cosmeceuticals for its various topical application benefits ranging from antioxidative, antiaging, anti‐inflammatory, and anti‐pigmentary among others. The main problems encountered with vitamin products include the stability, penetrance into skin, tolerance of C's forms. Aims This paper aims to explore current literature on role cosmetic dermatology present review how have developed certain purposes their outcomes. Methods A search was conducted PubMed reviewing non‐cosmetic formulations utility dermatologic conditions. Research produced by journals then investigated highlight uses potential field. Results Numerous studies support varied claims regarding C, particularly as an antioxidant, anti‐pigmentary, anti‐inflammatory agent. integration other ingredients rapidly developing, E natural plant extracts several exfoliative acids growth factors. industry's next steps involve better stabilization improve synergistic mechanisms without lowering bioavailability, efficacy, or absorption. Conclusions has proven be powerful player dermatology, both stand‐alone element combination ingredients. showcases some most pertinent clinical that efficacy mitigating photoaging, oxidative stress, abnormal pigmentation, inflammation concerns, underscoring promise behind C.

Язык: Английский

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Vitamin C: From Self-Sufficiency to Dietary Dependence in the Framework of Its Biological Functions and Medical Implications

Life, Год журнала: 2025, Номер 15(2), С. 238 - 238

Опубликована: Фев. 5, 2025

Vitamin C is an organic compound biosynthesized in plants and most vertebrates. Since its discovery, the benefits of vitamin use cure prevention various pathologies have been frequently reported, including anti-oxidant, anti-inflammatory, anticoagulant, immune modulatory properties. plays important role collagen synthesis subsequent scurvy prevention. It also required vivo as a cofactor for enzymes involved carnitine catecholamine norepinephrine biosynthesis, peptide amidation, tyrosine catabolism. Moreover, enzymatic cofactor, processes gene transcription epigenetic regulation. The absence L-gulono-1,4-lactone oxidase, key enzyme pathway synthesis, inborn metabolism error some fishes several bird mammalian species, humans non-human primates; it caused by changes structure original GULO gene, making these affected species dependent on external sources C. evolutionary cause pseudogenization remains controversial, either dietary supplementation or neutral selection evoked. An improvement control redox homeostasis was considered, potentially toxic H2O2 generated byproduct biosynthesis pathway. inactivation reliance may broader implications aging age-related diseases, one actions anti-oxidant. Therefore, aim medical professionals regarding human animal health should be establishing that are unable to synthesize themselves, preventing such cardiovascular cognitive decline, even cancer.

Язык: Английский

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Vitamin C ameliorates D-galactose-induced senescence in HEI-OC1 cells by inhibiting the ROS/NF-κB pathway

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Ноя. 15, 2024

Язык: Английский

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