Systemic Inflammatory Predictors of In-Hospital Mortality in COVID-19 Patients: A Retrospective Study

Diagnostics, Год журнала: 2022, Номер 12(4), С. 859 - 859

Опубликована: Март 30, 2022

The purpose of this study was to investigate whether routine blood tests and clinical characteristics can predict in-hospital mortality in COVID-19. Clinical data 285 patients aged 59.7 ± 10.3 yrs. (males n = 189, females 96) were retrospectively collected from December 2020 June 2021. Routine recorded within the 1st hour admission hospital. inflammatory variables, such as C-reactive protein (CRP), procalcitonin (PCT), neutrophils−lymphocyte ratio (NLR) systemic index (SII), exceeded reference values all significantly higher deceased (n 108) compared survivors 177). log-rank test for comparing two survival curves showed that ≥60.5 years, with PCT ≥ 0.188 ng/mL or NLR 11.57 103/µL at a greater risk death. demonstrated high impact on COVID-19 (HR 1.317; 95%CI 1.004−1.728; p < 0.05), whereas CRP SII no effect 1.000; 1.000−1.004; 0.085 HR 1.078; 0.865−1.344; 0.503, respectively). In first Polish including patients, we age relation simple parameters derived complete cell count has prognostic implications course identify mortality.

Язык: Английский

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Inflammaging at the Time of COVID-19

Clinics in Geriatric Medicine, Год журнала: 2022, Номер 38(3), С. 473 - 481

Опубликована: Март 21, 2022

Язык: Английский

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Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Allergy, Год журнала: 2023, Номер 79(5), С. 1089 - 1122

Опубликована: Дек. 18, 2023

Abstract The accumulation of senescent cells drives inflammaging and increases morbidity chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy substrates for proliferation, differentiation, activation. Metabolic imposed by environmental stress inflammation on immune tissue microenvironment thus chiefly involved the pathophysiology allergic other immune‐driven Altered is also a hallmark senescence, condition characterized loss proliferative activity remain metabolically active. Accelerated senescence can be triggered acute or responses. In contrast, replicative occurs as part physiological aging process has protective roles cancer surveillance wound healing. Importantly, change hamper response to diverse therapeutic treatments. Understanding metabolic pathways structural therefore critical detect, prevent, revert detrimental aspects senescence‐related immunopathology, developing specific diagnostics targeted therapies. this paper, we review main alterations occurring (macrophages, B cells, T cells). Subsequently, present footprints described translational studies patients with asthma obstructive pulmonary disease (COPD), ongoing preclinical clinical trials approaches aiming at targeting antagonize pathological senescence. Because recently emerging field allergy immunology, better understanding profile complex landscape needed. progress achieved so far already providing opportunities new therapies, well strategies aimed prevention supporting healthy aging.

Язык: Английский

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Sports and Immunity, from the recreational to the elite athlete

Infectious Diseases Now, Год журнала: 2024, Номер 54(4), С. 104893 - 104893

Опубликована: Март 24, 2024

The pivotal role of the immune system in physical activity is well-established. While interactions are complex, they tend to constitute discrete responses. Moderate intensity exercise causes leukocytosis with a mild anti-inflammatory cytokine profile and immunoenhancement. Above threshold intensity, lactate-mediated IL-6 release proinflammatory state followed by depressed inflammatory state, which stimulates adaptation longer term cardiometabolic enhancement. Exercise-related responses modulated sex, age immunonutrition. At all ability levels, these factors collectively affect balance between enhancement or overload dysfunction. Excessive training, mental stress insufficient recovery risks cell exhaustion hypothalamic pituitary axis (HPA) causing immunodepression negative impacts on performance general health. Participation sport provides additional benefits terms ensuring regularity, social inclusion, well-being healthier life choices diet reduced smoking alcohol, thereby consolidating healthy lifestyles Significant differences exist recreational professional athletes inherent characteristics, training resilience stresses arising from competition schedules, travel-related infections stress. Exercise immunology examines central immunity physiology straddles multiple disciplines ranging neuroendocrinology nutrition genetics, aim guiding train optimally safely. This review brief outline main exercise, some influencing factors, current guidance maintaining

Язык: Английский

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Biological aging of different blood cell types

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Июль 26, 2024

Abstract Biological age (BA) captures detrimental age-related changes. The best-known and most-used BA indicators include DNA methylation–based epigenetic clocks telomere length (TL). most common biological sample material for epidemiological aging studies, whole blood, is composed of different cell types. We aimed to compare differences in BAs between blood types assessed the indicators’ type-specific associations with chronological (CA). An analysis indicators, including TL, methylation level at cg16867657 ELOVL2 , as well Hannum, Horvath, DNAmPhenoAge, DunedinPACE clocks, was performed on 428 samples 12 values were majority pairwise comparisons types, comparison ( p < 0.05). DNAmPhenoAge showed largest type differences, up 44.5 years methylation-based TL lowest differences. T cells generally had "youngest" values, across subsets, whereas monocytes "oldest" values. All except DunedinPACE, strongly correlated CA within a type. Some such DNAmPhenoAge-difference naïve CD4 + constant regardless donor's (range 20–80 years), while they not. In conclusion, exhibit type–specific characteristics. Our results have implications understanding molecular mechanisms underlying underscore importance considering composition when utilizing them success interventions.

Язык: Английский

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Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies

Cells, Год журнала: 2025, Номер 14(7), С. 499 - 499

Опубликована: Март 27, 2025

Cellular senescence is an irreversible state of cell cycle arrest. Senescent cells (SCs) accumulate in the body with age and secrete harmful substances known as senescence-associated secretory phenotype (SASP), causing chronic inflammation; at same time, inflammation leads to a decrease immune system function, immunosenescence, which further accelerates aging process. immunosenescence are closely related variety diseases, including cardiovascular metabolic disorders, autoimmune neurodegenerative diseases. Studying mechanisms cellular developing targeted interventions crucial for improving function quality life elderly people. Here, we review series recent studies focusing on molecular regulation by system, latest advances basic clinical research senolytics. We summarize animal models research, well mechanisms, strategies, future directions from immunological perspective, hope laying foundation novel practical anti-aging therapies.

Язык: Английский

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Does excess body weight accelerate immune aging?

Experimental Gerontology, Год журнала: 2024, Номер 187, С. 112377 - 112377

Опубликована: Фев. 15, 2024

Overweight and obesity in older adults increase the risk of a range comorbidities by sustaining chronic inflammation thus enhancing immunosenescence. This study aimed to assess whether excess body mass affected disproportion T lymphocytes. Therefore, was designed explain individuals numbers lymphocytes anthropometric indices immune profile expressed as CD4/CD8 ratio are diagnostically useful analysis One hundred three aged 73.6 ± 3.1 years were allocated normal (body index (BMI) 18.5–24.9 kg/m2, n = 39), pre-obesity (BMI 25.0–29.9 44) or ≥30.0 20) group, based on WHO recommendations. Details subjects' medical history lifestyle obtained health questionnaire. Anthropometric performed bioelectrical impedance method, biochemical made automatic analyzer ELISA immunoassays, B lymphocyte counts determined eight-parameter flow cytometry. Additionally, visceral adiposity index, (BAI), shape (ABSI) evaluated circumference, BMI lipid-lipoprotein measurements. The highest percentage CD3+CD4+ (59.4 12.6 %) lowest CD3+CD8+ (31.6 10.0 noted patients group. cut-off value 1.9 for recorded vs model. > 2.5 >20 % our groups while 64.5 group had < 1. High diagnostic usefulness demonstrated both BAI lipid accumulation product (LAP) (AUC values ~0.800 ~ 0.900 respectively) models: pre-obesity, obesity, obesity. odds ratios (OR) model (OR 16.1, 95%CI 3.8–93.6) indicated potential clinical prognosis aging relation weight adults. AUC following + 0.927), LAP 1.00), ABSI 0.865) proved provide excellent discrimination between with mass.

Язык: Английский

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Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging

International Journal of Environmental Research and Public Health, Год журнала: 2021, Номер 18(24), С. 12949 - 12949

Опубликована: Дек. 8, 2021

Aging is characterized by several progressive physiological changes, including changes in the circadian rhythm. Circadian rhythms influence behavior, physiology, and metabolic processes order to maintain homeostasis; they also function of endothelial cells, smooth muscle immune cells vessel wall. A clock misalignment could favor vascular damage indirectly affect skeletal function. In this review, we focus on dysregulation rhythm due aging its relationship with health as possible risk factors for development sarcopenia, well role physical exercise a potential modulator these processes.

Язык: Английский

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Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Июнь 1, 2023

Methods: We examined whether immune cell profiles differ between healthy women (n = 38) and breast cancer survivors 27) within 2 years of treatment, any group-differences were influenced by age, cytomegalovirus infection, cardiorespiratory fitness body composition. Using flow cytometry, CD4+ CD8+ T subsets, including naïve (NA), central memory (CM) effector cells (EM EMRA) identified using CD27/CD45RA. Activation was measured HLA-DR expression. Stem cell-like (TSCMs) CD95/CD127. B cells, plasmablasts, memory, immature CD19/CD27/CD38/CD10. Effector regulatory Natural Killer CD56/CD16. Results: Compared to women, CM +Δ21% higher among (p 0.028) NA -Δ25% lower 0.034). Across the proportion activated (HLA-DR+) +Δ31% survivors: (+Δ25%), EM (+Δ32%) EMRA (+Δ43%), total (+Δ30%), (+Δ30%) (+Δ25%) < 0.046). The counts NK CD16+ (+Δ100%, +Δ108% +Δ143% respectively, p 0.04). Subsequent analyses statistically significant differences in participant characteristics, immunological groups. older (56 ± 6 y vs. 45 11 y), had (V˙O2max mL kg-1 min-1: 28.8 5.0 36.2 8.5), lean mass (42.3 kg 48.4 15.8 kg), fat (36.3% 5.3% 32.7% 6.4%) index (FMI kg/m2: 9.5 2.2 8.1 2.7) (all 0.033). Analysis covariance revealed divergent moderating effects CMV serostatus, composition on groups, depending type examined. Moreover, across all participants, positively associated with HLA-DR+ EM/EMRA (Pearson correlation: r > 0.305, 0.019). association withstood statistical adjustment for variables, fitness, potentially implicating these as contributors inflammatory/immune-dysfunction overweight/obesity.

Язык: Английский

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Pre-Existing Hypertension Is Related with Disproportions in T-Lymphocytes in Older Age

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(2), С. 291 - 291

Опубликована: Янв. 6, 2022

Age-related immune deficiencies increase the risk of comorbidities and mortality. This study evaluated immunosenescence patterns by flow cytometry naïve memory T cell subpopulations profile (IRP), expressed as CD4/CD8 ratio IgG CMV related to comorbidities. The disproportions in cells, well ratio, were analysed 99 elderly individuals (71.9 ± 5.8 years) diagnosed with hypertension (n = 51) or without 48), using an eight-parameter cytometer. percentage CD4+ lymphocytes was significantly higher hypertensive than other independently from infections, approximately 34% having > 2.5, only 4% < 1. a normal BMI demonstrated ≥ 1 ≤ while overweight obese participants showed tendency inverted ratio. increased gradually age reached highest values aged >75 years. decline more prominent CMV+ men when compared women. changes lymphocyte population, CD4/CD8, seropositivity included IRP are important markers health status that dependent on hypertension.

Язык: Английский

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