Materials chemistry horizons., Год журнала: 2024, Номер 3(2), С. 1 - 14
Опубликована: Ноя. 1, 2024
Язык: Английский
Toxics, Год журнала: 2024, Номер 12(4), С. 282 - 282
Опубликована: Апрель 11, 2024
Lead (Pb) and arsenic (As) are commonly occurring heavy metals in the environment produce detrimental impacts on central nervous system. Although they have both been indicated to exhibit neurotoxic properties, it is not known if joint effects, their mechanisms of action likewise unknown. In this study, zebrafish were exposed different concentrations Pb (40 μg/L, 4 mg/L), As (32 3.2 mg/L) combinations μg/L + 32 mg/L for 30 days. The histopathological analyses showed significant brain damage characterized by glial scar formation ventricular enlargement all groups. addition, either or staining inhibited swimming speed zebrafish, which was enhanced high a mixture. To elucidate underlying mechanisms, we examined changes acetylcholinesterase (AChE) activity, neurotransmitter (dopamine, 5-hydroxytryptamine) levels, HPI axis-related hormone (cortisol epinephrine) contents neurodevelopment-related gene expression brain. observations suggest that combined exposure can cause abnormalities behavior ultimately exacerbate neurotoxicity interfering with cholinergic system, dopamine 5-hydroxytryptamine signaling, axis function as well neuronal development. This study provides an important theoretical basis mixed toxicity aquatic organisms.
Язык: Английский
Процитировано
9
Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)
Опубликована: Март 4, 2025
The relationship between Alzheimer's disease (AD) and neuroimmunity has gradually begun to be unveiled. Emerging evidence indicates that cyclic GMP-AMP synthase (cGAS) acts as a cytosolic DNA sensor, recognizing damage-associated molecular patterns (DAMPs), inducing the innate immune response by activating stimulator of interferon genes (STING). Dysregulation this pathway culminates in AD-related neuroinflammation neurodegeneration. A substantial body mitochondria are involved critical pathogenic mechanisms AD, whose damage leads release mitochondrial (mtDNA) into extramitochondrial space. This leaked mtDNA serves DAMP, various pattern recognition receptors defense networks brain, including cGAS-STING pathway, ultimately leading an imbalance homeostasis. Therefore, modulation mtDNA-cGAS-STING restore neuroimmune homeostasis may offer promising prospects for improving AD treatment outcomes. In review, we focus on during stress activation pathway. Additionally, delve research progress further discuss primary directions potential hurdles developing targeted therapeutic drugs, gain deeper understanding pathogenesis provide new approaches its therapy.
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 849 - 849
Опубликована: Июнь 22, 2024
The state of well-being and health our body is regulated by the fine osmotic biochemical balance established between cells different tissues, organs, systems. Specific districts human are defined, kept in correct functioning, and, therefore, protected from exogenous or endogenous insults both mechanical, physical, biological nature presence barrier In addition to placental barrier, which even acts as a linker two organisms, mother fetus, all barriers, including blood-brain (BBB), blood-retinal blood-nerve blood-lymph blood-cerebrospinal fluid operate maintain physiological homeostasis within tissues organs. From pharmaceutical point view, most challenging undoubtedly BBB, since its notably complicates treatment brain disorders. BBB action can impair delivery chemical drugs biopharmaceuticals into brain, reducing their therapeutic efficacy and/or increasing unwanted bioaccumulation surrounding healthy tissues. Recent nanotechnological innovation provides advanced biomaterials ad hoc customized engineering functionalization methods able assist brain-targeted drug delivery. this context, lipid nanocarriers, synthetic (liposomes, solid nanoparticles, nanoemulsions, nanostructured carriers, niosomes, proniosomes, cubosomes) cell-derived ones (extracellular vesicles cell membrane-derived nanocarriers), considered one successful systems due reasonable biocompatibility ability cross BBB. This review aims provide complete up-to-date view on varied whether FDA-approved, involved clinical trials, used vitro vivo studies, for inflammatory, cancerous, infectious diseases.
Язык: Английский
Процитировано
6
Alzheimer s & Dementia, Год журнала: 2024, Номер 20(9), С. 6287 - 6304
Опубликована: Июль 17, 2024
Abstract INTRODUCTION Aging is one of the risk factors for early onset Alzheimer's disease (AD). We previously discovered that age‐dependent increase in Ubiquitin Conjugating Enzyme E2 N (UBE2N) plays a role accumulation misfolded proteins through K63 ubiquitination, which has been linked to AD pathogenesis. However, impact UBE2N on amyloid pathology and clearance remained unknown. RESULTS observed elevated during beta (Aβ) generation brains 5×FAD, APP/PS1 mice, patients with AD, comparison healthy individuals. overexpression exacerbated deposition 5×FAD mice senescent monkeys, whereas knocking down via CRISPR/Cas9 reduced Aβ cognitive deficiency. Moreover, pharmacological inhibition ameliorated subsequent transcript defects mice. DISCUSSION have expression critical regulator pathology. Our findings suggest could serve as potential target advancement therapeutics. Highlights level was mouse patients' brains. monkey. Drug
Язык: Английский
Процитировано
6
Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216601 - 216601
Опубликована: Март 10, 2025
Язык: Английский
Процитировано
0
Current topics in membranes, Год журнала: 2024, Номер unknown, С. 1 - 31
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
1
Advances in Clinical Medicine, Год журнала: 2024, Номер 14(09), С. 1034 - 1041
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Materials chemistry horizons., Год журнала: 2024, Номер 3(2), С. 1 - 14
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0