Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing

Bioactive Materials, Год журнала: 2023, Номер 24, С. 463 - 476

Опубликована: Янв. 6, 2023

Diabetes mellitus, an epidemic with a rapidly increasing number of patients, always leads to delayed wound healing associated consistent pro-inflammatory M1 polarization, decreased angiogenesis and increased reactive oxygen species (ROS) in the microenvironment. Herein, poly (lactic-co-glycolic acid) (PLGA)-based microneedle patch loaded magnesium hydride (MgH2) (MN-MgH2) is manufactured for defeating diabetic wounds. The application contributes transdermal delivery prolonged release MgH2 that can generate hydrogen (H2) ions (Mg2+) after reaction body fluids. released H2 reduces production ROS, transforming pathological microenvironment induced by diabetes mellitus. Meanwhile, Mg2+ promotes polarization pro-healing M2 macrophages. Consequently, cell proliferation migration are improved, tissue regeneration enhanced. Such intelligent provides novel way accelerating through steadily preserving releasing locally sustainably.

Язык: Английский

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SGLT-2 inhibitors and in-stent restenosis-related events after acute myocardial infarction: an observational study in patients with type 2 diabetes

BMC Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Фев. 24, 2023

No study evaluated the incidence of intra-stent restenosis (ISR)-related events in patients with type 2 diabetes (T2DM) and acute myocardial infarction (AMI) treated or not sodium/glucose cotransporter inhibitors (SGLT2i).We recruited 377 T2DM AMI undergoing percutaneous coronary intervention (PCI). Among them, 177 were SGLT2 before PCI. The primary outcome was major adverse cardiovascular (MACE) defined as cardiac death, re-infarction, heart failure related to ISR. In without ISR, minimal lumen area diameter assessed by CT-angiography at 1-year follow-up.Glycemic control similar SGLT2i-treated never SGLT2i-users. ISR-related MACE higher SGLT2i-users compared patients, an effect independent glycemic status (HR = 0.418, 95% CI 0.241-0.725, P 0.002) observed also subgroup HbA1c < 7% 0.393, 0.157-0.984, 0.027). event, stent patency greater follow-up.SGLT2i treatment is associated a reduced events, independently control.

Язык: Английский

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COVID-19 Causes Ferroptosis and Oxidative Stress in Human Endothelial Cells

Antioxidants, Год журнала: 2023, Номер 12(2), С. 326 - 326

Опубликована: Янв. 31, 2023

Oxidative stress and endothelial dysfunction have been shown to play crucial roles in the pathophysiology of COVID-19 (coronavirus disease 2019). On these grounds, we sought investigate impact on lipid peroxidation ferroptosis human cells. We hypothesized that oxidative induced by cells could be linked outcome. Thus, collected serum from patients hospital admission, incubated sera with cells, comparing effects generation reactive oxygen species (ROS) between who survived did not survive. found non-survivors significantly increased peroxidation. Moreover, markedly regulated expression levels main markers ferroptosis, including GPX4, SLC7A11, FTH1, SAT1, a response was rescued silencing TNFR1 Taken together, our data indicate survive triggers

Язык: Английский

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Hyperglycemia and Physical Impairment in Frail Hypertensive Older Adults

Frontiers in Endocrinology, Год журнала: 2022, Номер 13

Опубликована: Апрель 14, 2022

Frailty is a multidimensional condition typical of elders. Frail older adults have high risk functional decline, hospitalization, and mortality. Hypertension one the most common comorbidities in Hyperglycemia (HG) frequently observed frail adults, represents an independent predictor worst outcomes, with or without diabetes mellitus (DM). We aimed at investigating impact HG on physical impairment frailty.We studied consecutive frailty hypertension ASL (local health unit Italian Ministry Health) Avellino, Italy, from March 2021 to September 2021. Exclusion criteria were: age <65 years, no frailty, hypertension, left ventricular ejection fraction <25%, previous myocardial infarction, primary percutaneous coronary intervention and/or artery bypass grafting. Blood glucose, Hb1Ac, creatinine were measured all patients. Physical was assessed applying Fried Criteria; we performed 5-meter gait speed (5mGS) test patients.149 hypertensive enrolled study, which 82 had normoglycemia (NG), 67 HG. significantly slower 5mGS group compared NG (0.52 ± 0.1 vs. 0.69 0.06; p<0.001). Moreover, found strong significant correlation between glycemia (r: 0.833; A multivariable linear regression analysis using as dependent variable revealed association (p<0.001) after adjusting for likely confounders.HG drives independently DM.

Язык: Английский

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Glycemic Control and Coronary Stent Failure in Patients With Type 2 Diabetes Mellitus

Journal of the American College of Cardiology, Год журнала: 2024, Номер 84(3), С. 260 - 272

Опубликована: Май 14, 2024

Язык: Английский

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Glycaemic control in people with diabetes following acute myocardial infarction

Diabetes Research and Clinical Practice, Год журнала: 2023, Номер 199, С. 110644 - 110644

Опубликована: Март 29, 2023

Язык: Английский

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Sodium-Glucose Cotransporter-2 Inhibitors Stabilize Coronary Plaques in Acute Coronary Syndrome With Diabetes Mellitus

The American Journal of Cardiology, Год журнала: 2024, Номер 214, С. 47 - 54

Опубликована: Янв. 10, 2024

Язык: Английский

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Current Management of In-Stent Restenosis

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(8), С. 2377 - 2377

Опубликована: Апрель 19, 2024

In-stent restenosis (ISR) remains the primary cause of target lesion failure following percutaneous coronary intervention (PCI), resulting in 10-year incidences revascularization at a rate approximately 20%. The treatment ISR is challenging due to its inherent propensity for recurrence and varying susceptibility available strategies, influenced by complex interplay between clinical lesion-specific conditions. Given multiple mechanisms contributing development ISR, proper identification underlying substrate, especially using intravascular imaging, becomes pivotal as it can indicate distinct therapeutic requirements. Among standalone treatments, drug-coated balloon (DCB) angioplasty drug-eluting stent (DES) implantation have been most effective. main advantage DCB-based approach avoidance an additional metallic layer, which may otherwise enhance neointimal hyperplasia, provide substratum developing neoatherosclerosis, expose patient persistently higher risk ischemic events. On other hand, vessel scaffolding DES confers relevant mechanical advantages over DCB angioplasty, generally larger luminal gain, while drug elution from surface ensures inhibition hyperplasia. Nevertheless, repeat stenting with also implies permanent layer that reiterate promote leading ISR. Against this background, selection either or on patient- basis well implementation adjuvant including cutting/scoring balloons, lithotripsy, rotational atherectomy, hold potential improve effectiveness time. In review, we comprehensively assessed evidence randomized trials define contemporary interventional insights future directions.

Язык: Английский

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Omega-3 fatty acids coordinate glucose and lipid metabolism in diabetic patients

Lipids in Health and Disease, Год журнала: 2022, Номер 21(1)

Опубликована: Март 25, 2022

Omega 3 polyunsaturated fatty acids (n-3 PUFA) are known to have beneficial effects on cardiovascular and metabolic health. However, whether different sources of n-3 PUFA, for instance fish vs vegetable oils, could elicit glucose lipid metabolism, remains be determined. Herein we examine recent findings showing that while a plant-based PUFA supplementation six months can reduce fasting blood glucose, marine-based instead serum levels triglycerides. We also discuss the potential molecular mechanisms underlie these regulation glycolipid metabolism.

Язык: Английский

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Platelet bioenergetic profiling uncovers a metabolic pattern of high dependency on mitochondrial fatty acid oxidation in type 2 diabetic patients who developed in-stent restenosis

Redox Biology, Год журнала: 2024, Номер 72, С. 103146 - 103146

Опубликована: Апрель 2, 2024

Although platelet bioenergetic dysfunction is evident early in the pathogenesis of diabetic macrovascular complications, characteristics type 2 patients who developed coronary in-stent restenosis (ISR) and their effects on function remain unclear. Here, we performed profiling to characterize alterations 28 with ISR compared without (non-ISR) healthy individuals. Generally, platelets from exhibited a specific alteration characterized by high dependency fatty acid (FA) oxidation, which subsequently induced complex III deficiency, causing decreased mitochondrial respiration, increased oxidant production, low efficiency ATP generation. This pattern showed close relationships both α-granule dense granule secretion as measured surface P-selectin expression, release, profiles cargo proteins releasates. Importantly, ex vivo reproduction FA oxidation exposing non-ISR its agonist mimicked observed enhanced secretion, whereas pharmaceutical inhibition normalized respiratory redox states diminished secretion. Further, causal mediation analyses identified strong association between angiographical severity ISR, was significantly mediated status Our findings, for first time, uncover enhance current understanding mechanistic link abnormalities context diabetes.

Язык: Английский

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