Prognostic value of plasma phenylalanine and gut microbiota-derived metabolite phenylacetylglutamine in coronary in-stent restenosis DOI Creative Commons
Yuan Fu, Yixing Yang, Chen Fang

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2022, Volume and Issue: 9

Published: Aug. 30, 2022

This study was designed to explore the predictive value of plasma phenylalanine (Phe) and gut microbiota-derived metabolite phenylacetylglutamine (PAGln) in coronary in-stent restenosis (ISR).Patients with ISR, hyperplasia (ISH), patency (ISP) were retrospectively enrolled this study. Multivariable logistic regression analyses used identify independent risk factors ISR. The Phe PAGln levels evaluated by receiver operating characteristic (ROC) curve analysis. areas under ROC (AUCs) compared using Z-test. correlation between clinical characteristics examined Spearman's analysis.Seventy-two patients (mean age, 64.74 ± 9.47 years) divided into three groups according stent patency: ISR (n = 28), ISH 11), ISP 33) groups. significantly higher group than group. positively associated erythrocyte sedimentation rate, homocysteine, SYNTAX score, triglyceride high-density lipoprotein ratio, Phe, microbiota-related intermediate phenylacetic acid (PA). In group, aggravation restenosis, also elevated. multivariate analyses, score predictors (all P < 0.05). both [AUC 0.732; 95% confidence interval (CI), 0.606-0.858; 0.002] (AUC 0.861; CI, 0.766-0.957; 0.001) had good discrimination performance predicting power better (P 0.031).Plasma are valuable indices for microbes may be a promising intervention target prevent progression.

Language: Английский

Intelligent microneedle patch with prolonged local release of hydrogen and magnesium ions for diabetic wound healing DOI Creative Commons

Pei Wang,

Jiayingzi Wu, Haiyan Yang

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 24, P. 463 - 476

Published: Jan. 6, 2023

Diabetes mellitus, an epidemic with a rapidly increasing number of patients, always leads to delayed wound healing associated consistent pro-inflammatory M1 polarization, decreased angiogenesis and increased reactive oxygen species (ROS) in the microenvironment. Herein, poly (lactic-co-glycolic acid) (PLGA)-based microneedle patch loaded magnesium hydride (MgH2) (MN-MgH2) is manufactured for defeating diabetic wounds. The application contributes transdermal delivery prolonged release MgH2 that can generate hydrogen (H2) ions (Mg2+) after reaction body fluids. released H2 reduces production ROS, transforming pathological microenvironment induced by diabetes mellitus. Meanwhile, Mg2+ promotes polarization pro-healing M2 macrophages. Consequently, cell proliferation migration are improved, tissue regeneration enhanced. Such intelligent provides novel way accelerating through steadily preserving releasing locally sustainably.

Language: Английский

Citations

90
SGLT-2 inhibitors and in-stent restenosis-related events after acute myocardial infarction: an observational study in patients with type 2 diabetes DOI Creative Commons
Raffaele Marfella, Celestino Sardu, Nunzia D’Onofrio

et al.

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Feb. 24, 2023

No study evaluated the incidence of intra-stent restenosis (ISR)-related events in patients with type 2 diabetes (T2DM) and acute myocardial infarction (AMI) treated or not sodium/glucose cotransporter inhibitors (SGLT2i).We recruited 377 T2DM AMI undergoing percutaneous coronary intervention (PCI). Among them, 177 were SGLT2 before PCI. The primary outcome was major adverse cardiovascular (MACE) defined as cardiac death, re-infarction, heart failure related to ISR. In without ISR, minimal lumen area diameter assessed by CT-angiography at 1-year follow-up.Glycemic control similar SGLT2i-treated never SGLT2i-users. ISR-related MACE higher SGLT2i-users compared patients, an effect independent glycemic status (HR = 0.418, 95% CI 0.241-0.725, P 0.002) observed also subgroup HbA1c < 7% 0.393, 0.157-0.984, 0.027). event, stent patency greater follow-up.SGLT2i treatment is associated a reduced events, independently control.

Language: Английский

Citations

54
COVID-19 Causes Ferroptosis and Oxidative Stress in Human Endothelial Cells DOI Creative Commons
Stanislovas S. Jankauskas, Urna Kansakar, Celestino Sardu

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 326 - 326

Published: Jan. 31, 2023

Oxidative stress and endothelial dysfunction have been shown to play crucial roles in the pathophysiology of COVID-19 (coronavirus disease 2019). On these grounds, we sought investigate impact on lipid peroxidation ferroptosis human cells. We hypothesized that oxidative induced by cells could be linked outcome. Thus, collected serum from patients hospital admission, incubated sera with cells, comparing effects generation reactive oxygen species (ROS) between who survived did not survive. found non-survivors significantly increased peroxidation. Moreover, markedly regulated expression levels main markers ferroptosis, including GPX4, SLC7A11, FTH1, SAT1, a response was rescued silencing TNFR1 Taken together, our data indicate survive triggers

Language: Английский

Citations

48
Hyperglycemia and Physical Impairment in Frail Hypertensive Older Adults DOI Creative Commons

Antonella Pansini,

Angela Lombardi,

Maria Morgante

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: April 14, 2022

Frailty is a multidimensional condition typical of elders. Frail older adults have high risk functional decline, hospitalization, and mortality. Hypertension one the most common comorbidities in Hyperglycemia (HG) frequently observed frail adults, represents an independent predictor worst outcomes, with or without diabetes mellitus (DM). We aimed at investigating impact HG on physical impairment frailty.We studied consecutive frailty hypertension ASL (local health unit Italian Ministry Health) Avellino, Italy, from March 2021 to September 2021. Exclusion criteria were: age <65 years, no frailty, hypertension, left ventricular ejection fraction <25%, previous myocardial infarction, primary percutaneous coronary intervention and/or artery bypass grafting. Blood glucose, Hb1Ac, creatinine were measured all patients. Physical was assessed applying Fried Criteria; we performed 5-meter gait speed (5mGS) test patients.149 hypertensive enrolled study, which 82 had normoglycemia (NG), 67 HG. significantly slower 5mGS group compared NG (0.52 ± 0.1 vs. 0.69 0.06; p<0.001). Moreover, found strong significant correlation between glycemia (r: 0.833; A multivariable linear regression analysis using as dependent variable revealed association (p<0.001) after adjusting for likely confounders.HG drives independently DM.

Language: Английский

Citations

43
Glycemic Control and Coronary Stent Failure in Patients With Type 2 Diabetes Mellitus DOI
Irene Santos‐Pardo, Mikael Andersson,

Bo Lagerqvist

et al.

Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 84(3), P. 260 - 272

Published: May 14, 2024

Language: Английский

Citations

10
Glycaemic control in people with diabetes following acute myocardial infarction DOI Creative Commons
Harriet Esdaile, Neil Hill, Jamil Mayet

et al.

Diabetes Research and Clinical Practice, Journal Year: 2023, Volume and Issue: 199, P. 110644 - 110644

Published: March 29, 2023

Language: Английский

Citations

17
Sodium-Glucose Cotransporter-2 Inhibitors Stabilize Coronary Plaques in Acute Coronary Syndrome With Diabetes Mellitus DOI
Atsumasa Kurozumi, Koki Shishido, Takayoshi Yamashita

et al.

The American Journal of Cardiology, Journal Year: 2024, Volume and Issue: 214, P. 47 - 54

Published: Jan. 10, 2024

Language: Английский

Citations

6
Current Management of In-Stent Restenosis DOI Open Access
Daniele Giacoppo, Placido Maria Mazzone, Davide Capodanno

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(8), P. 2377 - 2377

Published: April 19, 2024

In-stent restenosis (ISR) remains the primary cause of target lesion failure following percutaneous coronary intervention (PCI), resulting in 10-year incidences revascularization at a rate approximately 20%. The treatment ISR is challenging due to its inherent propensity for recurrence and varying susceptibility available strategies, influenced by complex interplay between clinical lesion-specific conditions. Given multiple mechanisms contributing development ISR, proper identification underlying substrate, especially using intravascular imaging, becomes pivotal as it can indicate distinct therapeutic requirements. Among standalone treatments, drug-coated balloon (DCB) angioplasty drug-eluting stent (DES) implantation have been most effective. main advantage DCB-based approach avoidance an additional metallic layer, which may otherwise enhance neointimal hyperplasia, provide substratum developing neoatherosclerosis, expose patient persistently higher risk ischemic events. On other hand, vessel scaffolding DES confers relevant mechanical advantages over DCB angioplasty, generally larger luminal gain, while drug elution from surface ensures inhibition hyperplasia. Nevertheless, repeat stenting with also implies permanent layer that reiterate promote leading ISR. Against this background, selection either or on patient- basis well implementation adjuvant including cutting/scoring balloons, lithotripsy, rotational atherectomy, hold potential improve effectiveness time. In review, we comprehensively assessed evidence randomized trials define contemporary interventional insights future directions.

Language: Английский

Citations

6
Omega-3 fatty acids coordinate glucose and lipid metabolism in diabetic patients DOI Creative Commons
Pasquale Mone, Fahimeh Varzideh, Urna Kansakar

et al.

Lipids in Health and Disease, Journal Year: 2022, Volume and Issue: 21(1)

Published: March 25, 2022

Omega 3 polyunsaturated fatty acids (n-3 PUFA) are known to have beneficial effects on cardiovascular and metabolic health. However, whether different sources of n-3 PUFA, for instance fish vs vegetable oils, could elicit glucose lipid metabolism, remains be determined. Herein we examine recent findings showing that while a plant-based PUFA supplementation six months can reduce fasting blood glucose, marine-based instead serum levels triglycerides. We also discuss the potential molecular mechanisms underlie these regulation glycolipid metabolism.

Language: Английский

Citations

21
The association between the AIP and undiagnosed diabetes in ACS patients with different body mass indexes and LDL-C levels: findings from the CCC-ACS project DOI Creative Commons

Shuwan Xu,

Jun Liu, Dong Zhao

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Feb. 20, 2024

Abstract Background The atherogenic index of plasma (AIP) has been demonstrated to be significantly associated with the incidence prediabetes and diabetes. This study aimed investigate association between AIP undiagnosed diabetes in acute coronary syndrome (ACS) patients. Methods Among 113,650 ACS patients treated angiography at 240 hospitals Improving Care for Cardiovascular Disease China-ACS Project from 2014 2019, 11,221 available clinical surgical information were included. We analyzed these patients’ characteristics after stratification according tertiles, body mass (BMI) low-density lipoprotein cholesterol (LDL-C) levels. Results was independently a greater T3 group than T1 adjustment confounders [T3 OR 1.533 (1.199–1.959) p < 0.001]. relationship consistent within normal weight an LDL-C level ≥ 1.8 mmol/L. In overweight obese patients, as continuous variable age, sex, BMI but not categorical variable. area under receiver operating characteristic curve (AUC) score, triglyceride (TG) concentration, HDL-C concentration 0.601 (0.581–0.622; 0.001), 0.624 (0.603–0.645; 0.493 (0.472–0.514; = 0.524), respectively. A nonlinear found (p nonlinearity this trend remained males females. may negative biomarker ranging 0.176 0.738. Conclusion especially those or diabetes, male female ranges

Language: Английский

Citations

4