The association of the platelet/high-density lipoprotein cholesterol ratio with self-reported stroke and cardiovascular mortality: a population-based observational study

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Апрель 24, 2024

Abstract Background Previous studies have shown that the relationship between high-density lipoprotein cholesterol (HDL-C) and stroke is controversial, association platelet/high-density ratio (PHR), a novel marker for inflammation hypercoagulability states, has not been established. Methods This study presents an analysis of cross-sectional data from 2005–2018 National Health Nutrition Examination Survey (NHANES). Stroke history, HDL-C levels, platelet counts were obtained during surveys. The PHR was calculated as number platelets to concentration. Weighted logistic regression used assess associations with stroke. Nonlinearity this determined through restricted cubic splines (RCSs) two-piecewise linear identifying inflection points. Furthermore, Cox utilized prospectively analyze concentration cardiovascular disease (CVD) mortality in survivors. Results A total 27,301 eligible participants included study; mean age, 47.28 years 50.57% female, among whom 1,040 had history After full adjustment, odds (OR) associated per standard deviation (SD) increase estimated at 1.13 (95% confidence interval (CI): 1.03 − 1.24, P = 0.01), OR SD 0.95 CI: 0.86–1.05, 0.30). RCS indicated nonlinear both variables ( 0.018 0.003), further piecewise identified points 223.684 1.4 mmol/L. Segmental ≥ segment, per-SD 1.20 1.09 1.31, < 0.001), while significant before or after point > 0.05). showed linearly greater risk CVD survivors (HR: 1.14, 95% 1.06 1.22, 0.001; nonlinear, 0.956), significantly mortality. Conclusion incidence exhibited threshold effect, 223.684. exceeding positively stroke, significant. Additionally,

Язык: Английский

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Association between triglyceride-glucose related indices and mortality among individuals with non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Июль 4, 2024

Abstract Background The prognostic value of triglyceride-glucose (TyG) related indices in non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic (MASLD) is still unclear. This study aimed to determine the associations between TyG-related and long-term mortality this population. Methods data came from National Health Nutrition Examination Survey (NHANES III) Death Index (NDI). Baseline TyG, TyG combining with body mass index (TyG-BMI), waist circumference (TyG-WC) were calculated, status was determined through 31 December 2019. Multivariate Cox restricted cubic spline (RCS) regression models performed evaluate relationship among participants NAFLD/MASLD. In addition, we examined association all-cause within subgroups defined by age, sex, race/ethnicity, fibrosis-4 (FIB-4). Results There 10,390 completed ultrasonography laboratory included study. NAFLD diagnosed 3672/10,390 (35.3%) participants, while MASLD 3556/10,390 (34.2%) amongst overall multivariate analyses showed high levels indices, particularly TyG-BMI TyG-WC significantly associated mortality, cardiovascular diabetes either MASLD. RCS curves a nonlinear trend three Subgroup that more suitable for predicting patients without advanced fibrosis. Conclusion Our highlights clinical survival NAFLD/MASLD would be surrogate biomarkers follow-up population

Язык: Английский

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The triglyceride–glucose index and its obesity-related derivatives as predictors of all-cause and cardiovascular mortality in hypertensive patients: insights from NHANES data with machine learning analysis

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 29, 2025

Язык: Английский

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Insulin resistance surrogates are associated with all-cause mortality and cardiovascular mortality in population with metabolic syndrome: a retrospective cohort study of NHANES

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 8, 2025

The study aimed to assess the association of five insulin resistance surrogates, namely HOMA-β (Homeostasis Model Assessment Beta-cell Function), QUICKI (Quantitative Insulin Sensitivity Check Index), IGR (Insulin Glucose Ratio), e-IS (Estimated Sensitivity), and Bennett ISI(Bennett's sensitivity index) with all-cause cardiovascular mortality in respondents metabolic syndrome(MetS). prospective cohort 6662 participants aged 18 years older syndrome was extracted from National Health Nutrition Examination Survey(NHANES 1999–2016). multivariate Cox proportional hazards regression model, Kaplan-Meier survival curve, log-rank tests were applied determine between indices MetS population. Restricted cubic splines, a two-piece segmented threshold effect analyses performed evaluate nonlinear relationship. then conducted by removing individuals CKD, CHF, CAD, stroke, or cancer, respectively. All (IR) surrogates displayed negative syndrome. spline curves showed QUICKI, IGR, had relationship statistical significance. population at highest quartile exhibited lower event probabilities compared those lowest quartile, similar correlation events. Threshold that there inflection points for mortality. As gradually approached points, two types risks descended 15%[HR 0.85(0.80,0.91)] 19%[HR 0.81(0.71,0.92)], analysis indicated most results robust, but ISI did not exhibit significant outcomes without CKD. Our provides evidence HOMA-β, e-IS, reverse IR should be given more attention during follow-up

Язык: Английский

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Associations between estimated glucose disposal rate and arterial stiffness and mortality among US adults with non-alcoholic fatty liver disease

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Май 8, 2024

Background The estimated glucose disposal rate (eGDR), an effective indicator of insulin resistance, has been related to acute coronary syndrome, ischemic stroke and heart failure. This study aims explore the relationship between eGDR arterial stiffness, all-cause mortality cardiovascular in patients with non-alcoholic fatty liver disease (NAFLD). Methods Participants NAFLD were chosen from National Health Nutrition Examination Survey (NHANES) 1999 2018. main outcomes are stiffness (represented by pulse wave velocity, ePWV), mortality. Multiple cox regression models, restricted cubic spline, sensitivity analysis subgroup carried out investigate correlation resistance indicators stiffness. Furthermore, receiver operating characteristic curves used compare predictive value triglyceride-glucose (TyG) index homeostasis model assessment (HOMA-IR) for Results In this study, a total 4,861 participants included analysis. After adjusting confounding factors multivariate weighted model, was inversely associated (Q4 vs. Q1, HR =0.65 (0.48-0.89, P=0.01) =0.35 (0.19-0.65, P&lt;0.001). Compared TyG HOMA-IR, shows excellent (0.588 0.550 0.513, P &lt; 0.001) (0.625 0.553 0.537, 0.001). addition, we found significant negative (β=-0.13(-0.14–0.11, P&lt; However, HOMA-IR showed no Conclusions Low (an resistance) levels increased risk United States.

Язык: Английский

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Long-term survival in stroke patients: insights into triglyceride-glucose body mass index from ICU data

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Апрель 25, 2024

Abstract Background The Triglyceride Glucose-Body Mass Index (TyG-BMI) has been established as a robust indicator of insulin resistance (IR), reflecting metabolic health across various populations. In general, lower TyG-BMI values are often associated with better outcomes and reduced risk adverse events in non-critically ill Previous studies have highlighted significant negative association between all-cause mortality (ACM) among critically atrial fibrillation patients. Given the high prevalence severe stroke, understanding how at time ICU admission correlates ACM stroke patients becomes imperative. This study aims to assess correlation this specific patient cohort, exploring traditional associations may differ context acute, life-threatening illness. Methods Patient data were retrieved by accessing Medical Information Mart for Intensive Care IV (MIMIC-IV 2.2) database, categorizing into three groups on basis tertiles. evaluated both primary secondary outcomes: included 90-day, 180-day, 1-year ACM, while encompassed ICU, in-hospital, 30-day ACM. Our employed Kaplan–Meier (K–M) curve method outcome comparison utilizing multivariate Cox proportional-hazards regression models restricted cubic splines (RCS) explore these outcomes. Additionally, interaction subgroup analyses performed, focusing different points. Results Among cohort 1707 individuals diagnosed average age was 68 years (interquartile range [IQR]: 58–78 years), 946 (55.42%) participants being male. analysis K-M curves suggested that having level faced heightened long-term whereas short-term exhibited no statistically differences groups. Furthermore, validated increased belonging lowest tertile. RCS results demonstrated L-shaped correlations index short- These findings underscore predictive value patients, highlighting nuanced relationship varies over frames. revealed interactions stratified variables, exception age. Conclusion our study, levels significantly related higher within United States. finding suggests potential marker stratifying population. However, it's crucial note not observed indicating utility be more pronounced prediction. conclusion could serve reliable managing long term is preliminary. To confirm universal applicability prognostic tool, it conduct rigorously designed research

Язык: Английский

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Association of triglyceride-glucose-body mass index with all-cause and cardiovascular mortality among individuals with chronic kidney disease

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 4, 2024

Язык: Английский

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Association of different insulin resistance surrogates with all-cause and cardiovascular mortality among the population with cardiometabolic multimorbidity

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 22, 2025

Язык: Английский

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Associations of metabolic status with all-cause mortality among individuals with osteoarthritis: A prospective cohort study

Journal of Orthopaedic Translation, Год журнала: 2025, Номер 51, С. 207 - 217

Опубликована: Март 1, 2025

Язык: Английский

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The value of the platelet/high-density lipoprotein cholesterol ratio in predicting depression and its cardiovascular disease mortality: a population-based observational study

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Июль 29, 2024

Background Cardiovascular disease (CVD) and depression have a bidirectional association, with inflammation metabolic factors being common important triggers for both conditions. However, as novel inflammatory marker, platelet-to-HDL-C ratio (PHR) has not been established in relation to cardiovascular disease. Materials methods Participants aged 20 years older were included the 2005–2018 NHANES database. PHR was calculated of platelet count (1000 cells/μL) HDL-C (mmol/L). The Patient Health Questionnaire (PHQ-9) used diagnose depression, cutoff value 10. Weighted logistic regression analysis restricted cubic spline (RCS) employed examine association between depression-related features. Additionally, weighted COX RCS analyze CVD mortality patients depression. Receiver operating characteristic curves assess whether had an advantage over predicting Finally, mediating role latest health indicator Life’s Essential 8 explored. Results A total 26,970 eligible participants included, including 2,308 individuals representing approximately 160 million U.S. adults when weighted. After full adjustment, we estimated that odds (OR) associated per standard deviation (SD) increase 1.06 (95% CI: 1.01–1.12, P=0.03). indicated linear (Nonlinear P=0.113). When divided into four groups based on quartiles model after adjustment risk factors, quartile 2, 3, 4 showed trend increasing compared lowest group (P trend=0.01). In addition, revealed SD higher among (HR: 1.38, 95% 1.05–1.81, P=0.02, Nonlinear P=0.400). Subgroup analyses current alcohol consumption enhanced interaction=0.017). Furthermore, areas under ROC (AUC) 0.556 CI, 0.544–0.568; P &lt; 0.001) 0.536 0.524–0.549; DeLong = 0.025). mediation intermediate mechanism LE8 (mediation proportion=5.02%, P=0.02). Conclusion adults, linearly increases better predictive HDL-C. significantly mediates scores

Язык: Английский

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