Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 13, 2024
Evidence
regarding
the
neutrophil
percentage-to-albumin
ratio
(NPAR)
and
mortality
risk
in
diabetes
patients
is
scarce.
This
study
aimed
at
investigating
prognostic
value
of
NPAR
for
with
diabetes.
retrospective
analysis
was
conducted
on
6,962
diabetic
from
NHANES
database.
Restricted
cubic
spline
(RCS)
used
to
visualize
association
risk.
Weighted
multivariable
Cox
regression
models
subgroup
analyses
were
adopted
assess
all-cause
cardiovascular
mortality.
Time-dependent
receiver
operating
characteristic
curve
(ROC)
evaluate
accuracy
predicting
survival
outcomes.
Mediation
explored
indirect
impact
mediated
through
eGFR.
During
a
median
follow-up
6.7
years,
there
1,804
deaths
recorded,
including
602
deaths.
The
RCS
showed
that
has
J-shaped
mortality,
positive
linear
CVD
Each
one-unit
increase
linked
14%
12%
increased
respectively.
consistent
based
age,
sex,
race,
BMI,
hypertension,
CKD,
history
CVD.
time-dependent
ROC
area
under
0.809
0.780
In
mediation
analyses,
eGFR
partially
these
relationships.
An
elevated
independently
associated
patients.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 23, 2025
Neutrophil
percentage-to-albumin
ratio
(NPAR)
is
a
novel
inflammatory
biomarker
and
correlated
with
the
progression
clinical
outcomes
of
many
diseases.
This
investigation
aimed
to
clarified
association
between
NPAR
mortality
risk
among
hypertension
patients.
The
database
National
Health
Nutrition
Examination
Survey
provided
patient
data
for
hypertension.
Using
restricted
cubic
spline
(RCS),
was
investigated.
In
order
assess
independent
contribution
in
all-cause
cerebrovascular
mortality,
weighted
Cox
proportional
hazards
models
were
employed.
Concordance
index
receiver
operating
characteristic
(ROC)
curve
employed
how
effectively
predicted
at
different
times.
A
total
6,866
cases
included
this
investigation.
During
follow-up,
2,757
(40%)
patients
have
died,
582
(8.5%)
them
from
disease.
RCS
regression
analysis
found
positive
nonlinear
correlation
High
indicated
higher
risks
(HR
=
1.81,
95%
CI
1.52–2.37)
2.21,
1.67–2.88)
patients,
these
results
remained
after
adjusting
certain
parameters.
areas
under
5-year,
10-year
15-year
ROC
0.720,
0.703
0.634,
those
0.705,
0.706
0.699,
respectively.
served
as
s
Higher
mortality.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 31, 2025
Atherosclerotic
cardiovascular
disease
(ASCVD)
is
a
leading
cause
of
mortality
worldwide.
Dysregulation
glucose
metabolism
and
inflammation
are
key
factors
in
the
development
atherosclerosis.
The
glucose-to-lymphocyte
ratio
(GLR)
comprehensive
marker
for
assessing
inflammation.
This
study
aims
to
evaluate
association
between
GLR
all-cause
as
well
(CVD)
patients
with
ASCVD
within
U.S.
population.
retrospective
cohort
recruited
1,753
from
2003-2018
National
Health
Nutrition
Examination
Survey
(NHANES)
median
follow-up
6.25
years.
Mortality
outcomes
were
determined
by
linkage
Death
Index
(NDI)
records
up
December
31,
2019.
Weighted
Cox
proportional
hazard
models
used
assess
independent
risk.
Restricted
cubic
spline
(RCS)
curves
display
relationship
visually,
two-segment
hazards
constructed
on
either
side
inflection
points.
Kaplan-Meier
survival
further
mortality,
subgroup
analyses
performed.
Receiver
operating
characteristic
curve
(ROC)
analysis
was
conducted
predictive
ability
survival.
During
years,
624
deaths
various
causes
observed,
254
CVD.
regression
revealed
positive
both
CVD
mortality.
Based
RCS,
J-shaped
nonlinear
observed
patients,
an
point
at
3.13.
When
<
3.13,
it
showed
significant
negative
(HR
0.65,
95%
CI
0.47-0.89).
≥
3.13
there
correlation
1.13,
1.09-1.17).
Subgroup
across
most
subgroups,
but
weaker
compared
its
In
addition,
interaction
detected
age
relation
Moreover,
performance
seemed
superior
that
or
lymphocytes.
Our
findings
indicate
elevated
closely
associated
increased
risk
patients.
Notably,
exhibited
pattern,
Journal of Clinical Laboratory Analysis,
Год журнала:
2024,
Номер
38(21)
Опубликована: Окт. 10, 2024
ABSTRACT
Background
Neutrophil
percentage‐to‐albumin
ratio
(NPAR)
was
significantly
correlated
with
diabetes‐related
complications.
There
are
little
data
about
NPAR
and
mortality
risk
in
individuals
diabetes.
Methods
This
study
included
3858
diabetes
patients
from
the
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
1988
to
2018.
Using
a
restricted
cubic
spline
(RCS),
relationship
between
shown.
Multivariable
Cox
regression
models
were
used
evaluate
diabetes‐cause
all‐cause
death.
An
examination
of
time‐dependent
receiver
operating
characteristic
curve
(ROC)
assess
how
well
predicted
survival
outcomes.
Results
Among
individuals,
total
1198
(31.1%)
died
over
mean
follow‐up
7.86
years;
these,
326
(8.4%)
had
deaths
872
(22.6%)
other
causes.
The
RCS
analysis
showed
positive
linear
association
mortality.
High
group
higher
univariate
multivariate
analysis.
Compared
low
group,
high
rate
cases
death
area
under
3‐,
5‐,
10‐year
ROC
being
0.725,
0.739,
0.734
for
0.754,
0.752,
0.745
mortality,
respectively.
Conclusion
In
summary,
we
examined
NHANES
database
(1998–2018)
suggested
as
biomarker
prediction.
BMC Infectious Diseases,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июль 29, 2024
Abstract
Background
High
Neutrophil-to-Lymphocyte
Ratio
(NLR),
Monocyte-to-Lymphocyte
(MLR),
Platelet-to-Lymphocyte
(PLR)
were
associated
with
worse
prognosis
of
patients
sepsis.
In-hospital
mortality
has
been
reported
to
be
higher
in
coronary
artery
disease
(CAD)
and
sepsis
than
those
alone.
However,
the
relationship
between
NLR,
MLR,
PLR
septic
remains
unclear.
The
study
aimed
explore
association
28-day
all-cause
CAD.
Methods
We
performed
an
observational
cohort
CAD
from
Medical
Information
Mart
for
Intensive
Care
(MIMIC)-IV
database
2008
2019.
categorized
by
three
group
(Q1:
low
levels,
Q2:
medium
Q3:
high
levels)
based
on
tertiles
PLR.
associations
examined
using
Cox
proportional
hazards
model.
Subsequently,
we
applied
receiver
operating
characteristic
(ROC)
analysis
predicting
combining
MLR
modified
sequential
organ
failure
assessment
(mSOFA)
scores.
Results
Overall
1,175
included
study.
Observed
rates
28
days
27.1%.
Multivariate
regression
results
showed
that
was
significantly
related
rising
NLR
levels
(adjusted
hazard
ratio
[aHR]:
1.02;
95%
confidence
interval
[CI]:
1.01–1.02;
P
<
0.001),
(aHR:
1.29;
95%CI:
1.18–1.41;
1.0007;
1.0004–1.0011;
0.001).
Meanwhile,
(Q3)
also
had
a
risk
lower
(Q1)
group.
area
under
ROC
curve
PLR,
mSOFA
score
0.630
(95%CI
0.595–0.665),
0.611
0.576–0.646),
0.601
0.567–0.636)
0.718
0.689–0.748),
respectively.
Combining
scores
may
improve
ability
(AUC:
0.737,
95%CI
0.709–0.766).
Conclusion
Higher
Further
investigation
will
needed
understanding
pathophysiology
this
relationship.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Окт. 17, 2024
The
neutrophil-to-lymphocyte
ratio
(NLR),
a
simple
marker
of
systemic
inflammation,
is
crucial
in
the
progression
cardiovascular
diseases
(CVD).
Its
predictive
value
for
all-cause
and
mortality
CVD
patients
with
diabetes
or
pre-diabetes
remains
unclear.
We
analyzed
3,780
from
National
Health
Nutrition
Examination
Survey
(2001-2018).
Kaplan-Meier
survival
curves,
weighted
Cox
proportional
hazards
models,
restricted
cubic
spline
(RCS)
analyses
were
used
to
assess
relationship
between
NLR
risk.
RCS
revealed
U-shaped
association
mortality,
an
inflection
point
at
1.776.
For
<
1.776,
risk
decreased
by
13%
per
unit
increase
(HR:
0.87,
95%
CI:
0.76-0.98).
≥
increased
15%
1.15,
1.10-1.26).
A
positive
linear
was
found
17%
1.17,
1.10-1.25).
No
significant
interactions
observed
stratified
analyses.
Our
study
pre-diabetes.
Diagnostics,
Год журнала:
2024,
Номер
14(18), С. 2102 - 2102
Опубликована: Сен. 23, 2024
Background/Objectives:
Chronic
heart
failure
(CHF)
is
characterized
by
complex
pathophysiology,
leading
to
increased
hospitalizations
and
mortality.
Inflammatory
biomarkers
such
as
the
neutrophil-to-lymphocyte
ratio
(NLR)
platelet-to-lymphocyte
(PLR)
provide
valuable
diagnostic
insights.
Methods:
This
study
evaluates
prognostic
relationship
between
NLR,
PLR,
and,
in
a
specific
subcohort,
N-terminal
pro
B-type
natriuretic
peptide
(NT-proBNP),
alongside
length
of
stay
(LOS)
90-day
readmission
rates
CHF
patients,
irrespective
phenotype.
A
retrospective
analysis
427
admissions
(males
=
57.84%)
was
conducted.
Results:
The
mean
age
entire
population
68.48
±
11.53
years.
average
LOS
8.33
5.26
days,
with
rate
73
visits
(17.09%)
for
56
patients.
NLR
(3.79
3.32)
showed
low
but
positive
correlation
(r
0.222,
p
<
0.001).
Conversely,
PLR
(144.84
83.08)
did
not
demonstrate
significant
association
LOS.
presented
negative
days
until
next
admission
−0.023,
0.048).
In
prespecified
subanalysis
323
admissions,
NT-proBNP
exhibited
Pearson
0.241,
0.001)
0.151,
0.006).
Conclusions:
impact
across
phenotypes
may
suggest
role
systemic
inflammation
understanding
managing
CHF.
As
a
type
of
atherosclerotic
lesion
affecting
the
peripheral
vascular
system,
arterial
disease
(PAD)
has
an
elevated
disability
rate
and
seriously
affects
patients'
quality
life.
Estimated
pulse
wave
velocity
(ePWV)
is
alternative
indicator
closely
linked
with
atherosclerosis.
However,
link
between
ePWV
PAD
unelucidated.
