Elevated neutrophil percentage-to-albumin ratio predicts increased all-cause and cardiovascular mortality among individuals with diabetes

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 13, 2024

Evidence regarding the neutrophil percentage-to-albumin ratio (NPAR) and mortality risk in diabetes patients is scarce. This study aimed at investigating prognostic value of NPAR for with diabetes. retrospective analysis was conducted on 6,962 diabetic from NHANES database. Restricted cubic spline (RCS) used to visualize association risk. Weighted multivariable Cox regression models subgroup analyses were adopted assess all-cause cardiovascular mortality. Time-dependent receiver operating characteristic curve (ROC) evaluate accuracy predicting survival outcomes. Mediation explored indirect impact mediated through eGFR. During a median follow-up 6.7 years, there 1,804 deaths recorded, including 602 deaths. The RCS showed that has J-shaped mortality, positive linear CVD Each one-unit increase linked 14% 12% increased respectively. consistent based age, sex, race, BMI, hypertension, CKD, history CVD. time-dependent ROC area under 0.809 0.780 In mediation analyses, eGFR partially these relationships. An elevated independently associated patients.

Language: Английский

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Correlation between neutrophil percentage-to-albumin ratio and all-cause and cerebrovascular mortality among hypertension patients

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 23, 2025

Neutrophil percentage-to-albumin ratio (NPAR) is a novel inflammatory biomarker and correlated with the progression clinical outcomes of many diseases. This investigation aimed to clarified association between NPAR mortality risk among hypertension patients. The database National Health Nutrition Examination Survey provided patient data for hypertension. Using restricted cubic spline (RCS), was investigated. In order assess independent contribution in all-cause cerebrovascular mortality, weighted Cox proportional hazards models were employed. Concordance index receiver operating characteristic (ROC) curve employed how effectively predicted at different times. A total 6,866 cases included this investigation. During follow-up, 2,757 (40%) patients have died, 582 (8.5%) them from disease. RCS regression analysis found positive nonlinear correlation High indicated higher risks (HR = 1.81, 95% CI 1.52–2.37) 2.21, 1.67–2.88) patients, these results remained after adjusting certain parameters. areas under 5-year, 10-year 15-year ROC 0.720, 0.703 0.634, those 0.705, 0.706 0.699, respectively. served as s Higher mortality.

Language: Английский

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Association of glucose to lymphocyte ratio with the risk of death in patients with atherosclerotic cardiovascular disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 31, 2025

Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of mortality worldwide. Dysregulation glucose metabolism and inflammation are key factors in the development atherosclerosis. The glucose-to-lymphocyte ratio (GLR) comprehensive marker for assessing inflammation. This study aims to evaluate association between GLR all-cause as well (CVD) patients with ASCVD within U.S. population. retrospective cohort recruited 1,753 from 2003-2018 National Health Nutrition Examination Survey (NHANES) median follow-up 6.25 years. Mortality outcomes were determined by linkage Death Index (NDI) records up December 31, 2019. Weighted Cox proportional hazard models used assess independent risk. Restricted cubic spline (RCS) curves display relationship visually, two-segment hazards constructed on either side inflection points. Kaplan-Meier survival further mortality, subgroup analyses performed. Receiver operating characteristic curve (ROC) analysis was conducted predictive ability survival. During years, 624 deaths various causes observed, 254 CVD. regression revealed positive both CVD mortality. Based RCS, J-shaped nonlinear observed patients, an point at 3.13. When < 3.13, it showed significant negative (HR 0.65, 95% CI 0.47-0.89). ≥ 3.13 there correlation 1.13, 1.09-1.17). Subgroup across most subgroups, but weaker compared its In addition, interaction detected age relation Moreover, performance seemed superior that or lymphocytes. Our findings indicate elevated closely associated increased risk patients. Notably, exhibited pattern,

Language: Английский

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The association of serum hsa-miR-21-5p expression with the severity and prognosis of heart failure with reduced ejection fraction

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 19, 2025

Language: Английский

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Neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio associated with 28-day all-cause mortality in septic patients with coronary artery disease: a retrospective analysis of MIMIC-IV database

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 29, 2024

Abstract Background High Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte (MLR), Platelet-to-Lymphocyte (PLR) were associated with worse prognosis of patients sepsis. In-hospital mortality has been reported to be higher in coronary artery disease (CAD) and sepsis than those alone. However, the relationship between NLR, MLR, PLR septic remains unclear. The study aimed explore association 28-day all-cause CAD. Methods We performed an observational cohort CAD from Medical Information Mart for Intensive Care (MIMIC)-IV database 2008 2019. categorized by three group (Q1: low levels, Q2: medium Q3: high levels) based on tertiles PLR. associations examined using Cox proportional hazards model. Subsequently, we applied receiver operating characteristic (ROC) analysis predicting combining MLR modified sequential organ failure assessment (mSOFA) scores. Results Overall 1,175 included study. Observed rates 28 days 27.1%. Multivariate regression results showed that was significantly related rising NLR levels (adjusted hazard ratio [aHR]: 1.02; 95% confidence interval [CI]: 1.01–1.02; P < 0.001), (aHR: 1.29; 95%CI: 1.18–1.41; 1.0007; 1.0004–1.0011; 0.001). Meanwhile, (Q3) also had a risk lower (Q1) group. area under ROC curve PLR, mSOFA score 0.630 (95%CI 0.595–0.665), 0.611 0.576–0.646), 0.601 0.567–0.636) 0.718 0.689–0.748), respectively. Combining scores may improve ability (AUC: 0.737, 95%CI 0.709–0.766). Conclusion Higher Further investigation will needed understanding pathophysiology this relationship.

Language: Английский

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The Neutrophil Percentage‐to‐Albumin Ratio as a Biomarker for All‐Cause and Diabetes‐Cause Mortality Among Diabetes Patients: Evidence From the NHANES 1988–2018

Journal of Clinical Laboratory Analysis, Journal Year: 2024, Volume and Issue: 38(21)

Published: Oct. 10, 2024

ABSTRACT Background Neutrophil percentage‐to‐albumin ratio (NPAR) was significantly correlated with diabetes‐related complications. There are little data about NPAR and mortality risk in individuals diabetes. Methods This study included 3858 diabetes patients from the National Health Nutrition Examination Survey (NHANES) conducted 1988 to 2018. Using a restricted cubic spline (RCS), relationship between shown. Multivariable Cox regression models were used evaluate diabetes‐cause all‐cause death. An examination of time‐dependent receiver operating characteristic curve (ROC) assess how well predicted survival outcomes. Results Among individuals, total 1198 (31.1%) died over mean follow‐up 7.86 years; these, 326 (8.4%) had deaths 872 (22.6%) other causes. The RCS analysis showed positive linear association mortality. High group higher univariate multivariate analysis. Compared low group, high rate cases death area under 3‐, 5‐, 10‐year ROC being 0.725, 0.739, 0.734 for 0.754, 0.752, 0.745 mortality, respectively. Conclusion In summary, we examined NHANES database (1998–2018) suggested as biomarker prediction.

Language: Английский

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Association of neutrophil-to-lymphocyte ratio with all-cause and cardiovascular mortality in CVD patients with diabetes or pre-diabetes

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 17, 2024

The neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammation, is crucial in the progression cardiovascular diseases (CVD). Its predictive value for all-cause and mortality CVD patients with diabetes or pre-diabetes remains unclear. We analyzed 3,780 from National Health Nutrition Examination Survey (2001-2018). Kaplan-Meier survival curves, weighted Cox proportional hazards models, restricted cubic spline (RCS) analyses were used to assess relationship between NLR risk. RCS revealed U-shaped association mortality, an inflection point at 1.776. For < 1.776, risk decreased by 13% per unit increase (HR: 0.87, 95% CI: 0.76-0.98). ≥ increased 15% 1.15, 1.10-1.26). A positive linear was found 17% 1.17, 1.10-1.25). No significant interactions observed stratified analyses. Our study pre-diabetes.

Language: Английский

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Insights into the Neutrophil-to-Lymphocyte Ratio and the Platelet-to-Lymphocyte Ratio as Predictors for the Length of Stay and Readmission in Chronic Heart Failure Patients

Diagnostics, Journal Year: 2024, Volume and Issue: 14(18), P. 2102 - 2102

Published: Sept. 23, 2024

Background/Objectives: Chronic heart failure (CHF) is characterized by complex pathophysiology, leading to increased hospitalizations and mortality. Inflammatory biomarkers such as the neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) provide valuable diagnostic insights. Methods: This study evaluates prognostic relationship between NLR, PLR, and, in a specific subcohort, N-terminal pro B-type natriuretic peptide (NT-proBNP), alongside length of stay (LOS) 90-day readmission rates CHF patients, irrespective phenotype. A retrospective analysis 427 admissions (males = 57.84%) was conducted. Results: The mean age entire population 68.48 ± 11.53 years. average LOS 8.33 5.26 days, with rate 73 visits (17.09%) for 56 patients. NLR (3.79 3.32) showed low but positive correlation (r 0.222, p < 0.001). Conversely, PLR (144.84 83.08) did not demonstrate significant association LOS. presented negative days until next admission −0.023, 0.048). In prespecified subanalysis 323 admissions, NT-proBNP exhibited Pearson 0.241, 0.001) 0.151, 0.006). Conclusions: impact across phenotypes may suggest role systemic inflammation understanding managing CHF.

Language: Английский

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The Prognostic Value of Inflammatory Indices in Acute Pulmonary Embolism

Diagnostics, Journal Year: 2025, Volume and Issue: 15(3), P. 312 - 312

Published: Jan. 29, 2025

Background: Acute pulmonary embolism (PE) is a condition with increased morbidity and mortality. It important to identify patients high mortality risk. Inflammation thrombosis are interconnected in the pathophysiology of PE. The aim study was investigate prognostic value multiple blood cellular indices such as neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte (LMR), platelet-to-lymphocyte (PLR), platelet (NLPR), systemic immune–inflammation index (SII), inflammation response (SIRI) aggregate (AISI) acute Methods: A total 157 PE confirmed by chest computed tomographic angiography (CTPA) were enrolled. These divided into two categories according simplified severity (sPESI): risk low Results: Univariate logistic regression analysis showed that right ventricle dysfunction, NLR, SII SIRI significantly associated NLR 4.32 high-risk sensitivity 57.4% specificity 65.7% (AUC = 0.635). 1086.55 55.7% 71.4% 0.614). 2.87 59% 62.9% 0.624). Multivariate demonstrated PLR NLPR independent predictors Secondly, NLPR, correlated in-hospital Based on receiver-operating characteristic (ROC) curve values 7.66 for 0.911, 85.7% sensibility 83%), 0.02 0.871, 70%), 1542.71 0.782, 72%) 5.72 0.788, 73%) could predict Conclusions: (NLR, SIRI) Right ventricular

Language: Английский

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Development and validation of a novel metabolic health-related nomogram to improve predictive performance of cardiovascular disease risk in patients with prediabetes

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 11, 2025

The prevalence of prediabetes among adults in the U.S. is three times higher than that diabetes, highlighting a greater disease burden. Both diabetes and have been demonstrated to be associated with an increased risk cardiovascular (CVD). However, research has primarily focused on limited attention CVD prediction prediabetes. Emerging 13 metabolic health-related indicators proposed optimize predictive effect patients This study aimed compare efficacy these biomarkers further develop nomogram improve performance All eligible participants National Health Nutrition Examination Survey (NHANES) 1999–2020 were enrolled this randomly assigned development validation cohorts ratio 7:3. In cohort, used predict was assessed by receiver operative characteristic (ROC) curves. Independent predictors identified multivariate logistic regression construct nomogram, internal external implemented. ROC curve triglyceride-glucose (TyG) index effective predictor [area under (AUC) = 0.694] exhibited best indices. Based independent factors regression, [including age, gender, hypertension, TyG, stress hyperglycemia (SHR), neutrophil-to-lymphocyte (NLR)] successfully constructed validated good (AUCs/C-indexes > 0.70 for all). developed reliable predicting model robust offered simple yet individualized approach

Language: Английский

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