Gut microbiota in health and disease: advances and future prospects
MedComm,
Год журнала:
2024,
Номер
5(12)
Опубликована: Ноя. 20, 2024
Abstract
The
gut
microbiota
plays
a
critical
role
in
maintaining
human
health,
influencing
wide
range
of
physiological
processes,
including
immune
regulation,
metabolism,
and
neurological
function.
Recent
studies
have
shown
that
imbalances
composition
can
contribute
to
the
onset
progression
various
diseases,
such
as
metabolic
disorders
(e.g.,
obesity
diabetes)
neurodegenerative
conditions
Alzheimer's
Parkinson's).
These
are
often
accompanied
by
chronic
inflammation
dysregulated
responses,
which
closely
linked
specific
forms
cell
death,
pyroptosis
ferroptosis.
Pathogenic
bacteria
trigger
these
death
pathways
through
toxin
release,
while
probiotics
been
found
mitigate
effects
modulating
responses.
Despite
insights,
precise
mechanisms
influences
diseases
remain
insufficiently
understood.
This
review
consolidates
recent
findings
on
impact
immune‐mediated
inflammation‐associated
conditions.
It
also
identifies
gaps
current
research
explores
potential
advanced
technologies,
organ‐on‐chip
models
microbiome–gut–organ
axis,
for
deepening
our
understanding.
Emerging
tools,
single‐bacterium
omics
spatial
metabolomics,
discussed
their
promise
elucidating
microbiota's
disease
development.
Язык: Английский
Liver organoids: updates on generation strategies and biomedical applications
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Авг. 7, 2024
The
liver
is
the
most
important
metabolic
organ
in
body.
While
mouse
models
and
cell
lines
have
further
deepened
our
understanding
of
biology
related
diseases,
they
are
flawed
replicating
key
aspects
human
tissue,
particularly
its
complex
structure
functions.
organoid
model
represents
a
major
breakthrough
that
revolutionized
biomedical
research.
Organoids
vitro
three-dimensional
(3D)
physiological
structures
recapitulate
morphological
functional
characteristics
tissues
vivo,
significant
advantages
over
traditional
culture
methods.
In
this
review,
we
discuss
generation
strategies
current
advances
field
focusing
on
their
application
regenerative
medicine,
drug
discovery
modeling
diseases.
Язык: Английский
Ex Vivo Tools and Models in MASLD Research
Cells,
Год журнала:
2024,
Номер
13(22), С. 1827 - 1827
Опубликована: Ноя. 5, 2024
Metabolic
dysfunction-associated
fatty
liver
disease
(MASLD)
presents
a
growing
global
health
challenge
with
limited
therapeutic
choices.
This
review
delves
into
the
array
of
ex
vivo
tools
and
models
utilized
in
MASLD
research,
encompassing
liver-on-a-chip
(LoC)
systems,
organoid-derived
tissue-like
structures,
human
precision-cut
slice
(PCLS)
systems.
Given
urgent
need
to
comprehend
pathophysiology
identify
novel
targets,
this
paper
aims
shed
light
on
pivotal
role
advanced
enhancing
understanding
facilitating
development
potential
therapies.
Despite
challenges
posed
by
elusive
mechanism,
these
innovative
methodologies
offer
promise
reducing
utilization
for
research
while
accelerating
drug
discovery
biomarker
identification,
thereby
addressing
critical
unmet
clinical
needs.
Язык: Английский
Advancing healthcare through laboratory on a chip technology: Transforming microorganism identification and diagnostics
World Journal of Clinical Cases,
Год журнала:
2024,
Номер
13(3)
Опубликована: Ноя. 8, 2024
In
a
recent
case
report
in
the
World
Journal
of
Clinical
Cases,
emphasized
crucial
role
rapidly
and
accurately
identifying
pathogens
to
optimize
patient
treatment
outcomes.
Laboratory-on-a-chip
(LOC)
technology
has
emerged
as
transformative
tool
health
care,
offering
rapid,
sensitive,
specific
identification
microorganisms.
This
editorial
provides
comprehensive
overview
LOC
technology,
highlighting
its
principles,
advantages,
applications,
challenges,
future
directions.
Success
studies
from
field
have
demonstrated
practical
benefits
devices
clinical
diagnostics,
epidemiology,
food
safety.
Comparative
underscored
superiority
over
traditional
methods,
showcasing
improvements
speed,
accuracy,
portability.
The
integration
with
biosensors,
artificial
intelligence,
data
analytics
promises
further
innovation
expansion.
call
action
emphasizes
importance
continued
research,
investment,
adoption
realize
full
potential
improving
healthcare
outcomes
worldwide.
Язык: Английский