Advancing healthcare through laboratory on a chip technology: Transforming microorganism identification and diagnostics DOI
Carlos M. Ardila

World Journal of Clinical Cases, Год журнала: 2024, Номер 13(3)

Опубликована: Ноя. 8, 2024

In a recent case report in the World Journal of Clinical Cases, emphasized crucial role rapidly and accurately identifying pathogens to optimize patient treatment outcomes. Laboratory-on-a-chip (LOC) technology has emerged as transformative tool health care, offering rapid, sensitive, specific identification microorganisms. This editorial provides comprehensive overview LOC technology, highlighting its principles, advantages, applications, challenges, future directions. Success studies from field have demonstrated practical benefits devices clinical diagnostics, epidemiology, food safety. Comparative underscored superiority over traditional methods, showcasing improvements speed, accuracy, portability. The integration with biosensors, artificial intelligence, data analytics promises further innovation expansion. call action emphasizes importance continued research, investment, adoption realize full potential improving healthcare outcomes worldwide.

Язык: Английский

Gut microbiota in health and disease: advances and future prospects DOI Creative Commons
Y J Zhang, Hong Wang, Yingpeng Sang

и другие.

MedComm, Год журнала: 2024, Номер 5(12)

Опубликована: Ноя. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Язык: Английский

Процитировано

8

Liver organoids: updates on generation strategies and biomedical applications DOI Creative Commons
Sen Liu, Chuanliang Cheng,

Liuyang Zhu

и другие.

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 7, 2024

The liver is the most important metabolic organ in body. While mouse models and cell lines have further deepened our understanding of biology related diseases, they are flawed replicating key aspects human tissue, particularly its complex structure functions. organoid model represents a major breakthrough that revolutionized biomedical research. Organoids vitro three-dimensional (3D) physiological structures recapitulate morphological functional characteristics tissues vivo, significant advantages over traditional culture methods. In this review, we discuss generation strategies current advances field focusing on their application regenerative medicine, drug discovery modeling diseases.

Язык: Английский

Процитировано

2

Ex Vivo Tools and Models in MASLD Research DOI Creative Commons
Rallia-Iliana Velliou,

Eirini Giannousi,

Christiana Ralliou

и другие.

Cells, Год журнала: 2024, Номер 13(22), С. 1827 - 1827

Опубликована: Ноя. 5, 2024

Metabolic dysfunction-associated fatty liver disease (MASLD) presents a growing global health challenge with limited therapeutic choices. This review delves into the array of ex vivo tools and models utilized in MASLD research, encompassing liver-on-a-chip (LoC) systems, organoid-derived tissue-like structures, human precision-cut slice (PCLS) systems. Given urgent need to comprehend pathophysiology identify novel targets, this paper aims shed light on pivotal role advanced enhancing understanding facilitating development potential therapies. Despite challenges posed by elusive mechanism, these innovative methodologies offer promise reducing utilization for research while accelerating drug discovery biomarker identification, thereby addressing critical unmet clinical needs.

Язык: Английский

Процитировано

1

Advancing healthcare through laboratory on a chip technology: Transforming microorganism identification and diagnostics DOI
Carlos M. Ardila

World Journal of Clinical Cases, Год журнала: 2024, Номер 13(3)

Опубликована: Ноя. 8, 2024

In a recent case report in the World Journal of Clinical Cases, emphasized crucial role rapidly and accurately identifying pathogens to optimize patient treatment outcomes. Laboratory-on-a-chip (LOC) technology has emerged as transformative tool health care, offering rapid, sensitive, specific identification microorganisms. This editorial provides comprehensive overview LOC technology, highlighting its principles, advantages, applications, challenges, future directions. Success studies from field have demonstrated practical benefits devices clinical diagnostics, epidemiology, food safety. Comparative underscored superiority over traditional methods, showcasing improvements speed, accuracy, portability. The integration with biosensors, artificial intelligence, data analytics promises further innovation expansion. call action emphasizes importance continued research, investment, adoption realize full potential improving healthcare outcomes worldwide.

Язык: Английский

Процитировано

0