Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Окт. 6, 2023

Abstract Skin cancer is a global threat to the healthcare system and estimated incline tremendously in next 20 years, if not diagnosed at an early stage. Even though it curable stage, novel drug identification, clinical success, resistance another major challenge. To bridge gap bring effective treatment, important understand etiology of skin carcinoma, mechanism cell proliferation, factors affecting growth, resistance. The current article focusses on understanding structural diversity cancers, treatments available till date including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgery, combination molecular targets associated with growth metastasis, special emphasis nanotechnology-based approaches for downregulating deleterious disease. A detailed analysis respect types nanoparticles their scope overcoming multidrug as well trials has been discussed. Graphical

Язык: Английский

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RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions

Cancer Medicine, Год журнала: 2024, Номер 13(2)

Опубликована: Янв. 1, 2024

RGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, fibrinogen. peptides' principal function is to facilitate by interacting with integrin receptors on the surface. They have been intensively researched for use biotechnology medicine, including incorporation into biomaterials, conjugation medicinal molecules or nanoparticles, labeling imaging agents. peptides utilized specifically target cancer cells tumor vasculature engaging these integrins, improving drug delivery efficiency minimizing adverse effects healthy tissues. RGD-functionalized carriers are a viable option therapy this focused approach has demonstrated promise future. Writing review significantly influence how drugs developed future our understanding of peptide, finding knowledge gaps, fostering innovation, making design easier.

Язык: Английский

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Advancements in dextran-based nanocarriers for treatment and imaging of breast cancer

International Journal of Pharmaceutics, Год журнала: 2023, Номер 643, С. 123276 - 123276

Опубликована: Июль 27, 2023

Язык: Английский

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Carbon nanotube-mediated platinum-based drug delivery for the treatment of cancer: Advancements and future perspectives

European Polymer Journal, Год журнала: 2024, Номер 206, С. 112800 - 112800

Опубликована: Янв. 26, 2024

Язык: Английский

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PROTAC Prodrug‐Integrated Nanosensitizer for Potentiating Radiation Therapy of Cancer

Advanced Materials, Год журнала: 2024, Номер 36(23)

Опубликована: Фев. 14, 2024

Abstract Radiation therapy (RT) is one of the primary options for clinical cancer therapy, in particular advanced head and neck squamous cell carcinoma (HNSCC). Herein, crucial role bromodomain‐containing protein 4 (BRD4)‐RAD51 associated 1 (RAD51AP1) axis sensitizing RT HNSCC revealed. A versatile nanosensitizer (RPB7H) thus innovatively engineered by integrating a PROteolysis TArgeting Chimeras (PROTAC) prodrug (BPA771) hafnium dioxide (HfO 2 ) nanoparticles to downregulate BRD4‐RAD51AP1 pathway sensitize tumor RT. Upon intravenous administration, RPB7H selectively accumulate at tissue internalize into cells recognizing neuropilin‐1 overexpressed mass. HfO enhance effectiveness amplifying X‐ray deposition, intensifying DNA damage, boosting oxidative stress. Meanwhile, BPA771 can be activated RT‐induced H O secretion degrade BRD4 inactivate RAD51AP1, impeding damage repair. This nanosensitizer, combined with irradiation, effectively regresses growth mouse model. The findings introduce PROTAC prodrug‐based radiosensitization strategy targeting axis, may offer promising avenue augment more effective therapy.

Язык: Английский

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The cubosome-based nanoplatforms in cancer therapy: Seeking new paradigms for cancer theranostics

Environmental Research, Год журнала: 2023, Номер 237, С. 116894 - 116894

Опубликована: Авг. 14, 2023

Язык: Английский

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Aptamer-grafted, cell membrane-coated dendrimer loaded with doxorubicin as a targeted nanosystem against epithelial cellular adhesion molecule (EpCAM) for triple negative breast cancer therapy

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 86, С. 104745 - 104745

Опубликована: Июль 7, 2023

Язык: Английский

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Unravelling the potential of mitochondria-targeted liposomes for enhanced cancer treatment

Drug Discovery Today, Год журнала: 2023, Номер 29(1), С. 103819 - 103819

Опубликована: Ноя. 7, 2023

Язык: Английский

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Photodynamically Tumor Vessel Destruction Amplified Tumor Targeting of Nanoparticles for Efficient Chemotherapy

ACS Nano, Год журнала: 2024, Номер 18(20), С. 12933 - 12944

Опубликована: Май 7, 2024

Efficient tumor-targeted drug delivery is still a challenging and currently unbreakable bottleneck in chemotherapy for tumors. Nanomedicines based on passive or active targeting strategy have not yet achieved convincing chemotherapeutic benefits the clinic due to tumor heterogeneity. Inspired by efficient inflammatory-cell recruitment acute clots, we constructed two-component nanosystem, which composed of an RGD-modified pyropheophorbide-a (Ppa) micelle (PPRM) that mediates vascular-targeted photodynamic reaction activate local coagulation subsequently transmits signals circulating clot-targeted CREKA peptide-modified camptothecin (CPT)-loaded nanodiscs (CCNDs) amplifying targeting. PPRM could effectively bind with vasculature induce sufficient thrombus reaction. Local reaction-induced target amplification greatly increased accumulation CCND 4.2 times, thus significantly enhancing efficacy 4T1 breast model. In other words, this study provides powerful platform amplify tumor-specific taking advantage crosstalk between PPRM-activated cascade CCND.

Язык: Английский

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Advancements of metallic nanoparticles: A promising frontier in cancer treatment

Science Progress, Год журнала: 2024, Номер 107(4)

Опубликована: Окт. 1, 2024

The incidence of cancer is increasing and evolving as a major source mortality. Nanotechnology has garnered considerable scientific interest in recent decades can offer promising solution to the challenges encountered with traditional chemotherapy. Nanoparticle utilization holds promise combating other diseases, offering exciting prospects for drug delivery systems medicinal applications. Metallic nanoparticles exhibit remarkable physical chemical properties, such their minute size, composition, structure, extensive surface area, rendering them versatile cost-effective. Research demonstrated significant beneficial impact on treatment, characterized by enhanced targeting abilities, gene activity suppression, improved efficiency. By incorporating ligands, functionalized metal ensure precise energy deposition within tumors, thereby augmenting treatment accuracy. Moreover, beyond therapeutic efficacy, serve valuable tools cell visualization, contributing diagnostic techniques. Utilizing allows simultaneous diagnosis while also facilitating controlled release, thus revolutionizing care. This narrative review investigates advancements types mechanisms cells, application clinical scenarios, potential toxicity medicine.

Язык: Английский

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