Development of Iron Oxide Nanochains as a Sensitive Magnetic Particle Imaging Tracer for Cancer Detection DOI Creative Commons
P. P. Praveen Kumar,

Md Nafiujjaman,

Ashley V. Makela

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

The advancement of imaging technologies plays a crucial role in improving the diagnosis and monitoring diseases, including cancer. This study introduces new design iron oxide-based nanoparticles specifically developed for magnetic particle (MPI), aimed at tracking diagnosing breast cancer more effectively. By precisely controlling size, shape, properties these nanoparticles, we enhance responsiveness MPI, resulting an increased signal. In our research, established novel synthetic route fabricating oxide nanochains (FeONCs) characterized by their uniform shape which contribute to high suitable MPI applications. Initial results indicate FeONCs exhibit superior compared conventional spherical superparamagnetic nanocubes, reported nanoworm-type structures. Magnetic relaxometry studies revealed that provide higher sensitivity than commonly used VivoTrax Synomag D50 D70 MPI. Further, size significantly influence cellular uptake. vivo experiments using orthotopic mouse models allow us assess biocompatibility characteristics confirming efficacy. Furthermore, conjugating with RGD peptide, ability target cancer, establishing them as promising tracers applications sensitivity. Thus, findings highlight improve quality, facilitating early detection accurate paves way innovative diagnostic strategies personalized treatment options. Future research will focus on fine-tuning surface chemistry further targeting efficiency optimization practice clinical applications, particularly MPI-based hyperthermia therapy.

Language: Английский

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches DOI Creative Commons
Nazeer Hasan, Arif Nadaf, Mohammad Imran

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 6, 2023

Abstract Skin cancer is a global threat to the healthcare system and estimated incline tremendously in next 20 years, if not diagnosed at an early stage. Even though it curable stage, novel drug identification, clinical success, resistance another major challenge. To bridge gap bring effective treatment, important understand etiology of skin carcinoma, mechanism cell proliferation, factors affecting growth, resistance. The current article focusses on understanding structural diversity cancers, treatments available till date including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgery, combination molecular targets associated with growth metastasis, special emphasis nanotechnology-based approaches for downregulating deleterious disease. A detailed analysis respect types nanoparticles their scope overcoming multidrug as well trials has been discussed. Graphical

Language: Английский

Citations

110
RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions DOI Creative Commons
Hossein Javid, Mahsa Akbari Oryani,

Nastaran Rezagholinejad

et al.

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(2)

Published: Jan. 1, 2024

RGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, fibrinogen. peptides' principal function is to facilitate by interacting with integrin receptors on the surface. They have been intensively researched for use biotechnology medicine, including incorporation into biomaterials, conjugation medicinal molecules or nanoparticles, labeling imaging agents. peptides utilized specifically target cancer cells tumor vasculature engaging these integrins, improving drug delivery efficiency minimizing adverse effects healthy tissues. RGD-functionalized carriers are a viable option therapy this focused approach has demonstrated promise future. Writing review significantly influence how drugs developed future our understanding of peptide, finding knowledge gaps, fostering innovation, making design easier.

Language: Английский

Citations

62
Advancements in dextran-based nanocarriers for treatment and imaging of breast cancer DOI
Mohammad Sameer Khan, B.H. Jaswanth Gowda, Nazim Nasir

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 643, P. 123276 - 123276

Published: July 27, 2023

Language: Английский

Citations

59
PROTAC Prodrug‐Integrated Nanosensitizer for Potentiating Radiation Therapy of Cancer DOI
Shunan Zhang, Yi Lai,

Jiaxing Pan

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 14, 2024

Abstract Radiation therapy (RT) is one of the primary options for clinical cancer therapy, in particular advanced head and neck squamous cell carcinoma (HNSCC). Herein, crucial role bromodomain‐containing protein 4 (BRD4)‐RAD51 associated 1 (RAD51AP1) axis sensitizing RT HNSCC revealed. A versatile nanosensitizer (RPB7H) thus innovatively engineered by integrating a PROteolysis TArgeting Chimeras (PROTAC) prodrug (BPA771) hafnium dioxide (HfO 2 ) nanoparticles to downregulate BRD4‐RAD51AP1 pathway sensitize tumor RT. Upon intravenous administration, RPB7H selectively accumulate at tissue internalize into cells recognizing neuropilin‐1 overexpressed mass. HfO enhance effectiveness amplifying X‐ray deposition, intensifying DNA damage, boosting oxidative stress. Meanwhile, BPA771 can be activated RT‐induced H O secretion degrade BRD4 inactivate RAD51AP1, impeding damage repair. This nanosensitizer, combined with irradiation, effectively regresses growth mouse model. The findings introduce PROTAC prodrug‐based radiosensitization strategy targeting axis, may offer promising avenue augment more effective therapy.

Language: Английский

Citations

29
Carbon nanotube-mediated platinum-based drug delivery for the treatment of cancer: Advancements and future perspectives DOI
Mohammad Sameer Khan, B.H. Jaswanth Gowda, Nazeer Hasan

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 206, P. 112800 - 112800

Published: Jan. 26, 2024

Language: Английский

Citations

27
Pharmaceutical orientation and applications of silver/zinc oxide nanoparticles developed from various fruit peel extracts: an emerging sustainable approach DOI Creative Commons
Mahima Chaudhary, Priyvart Choudhary, Anjali Tripathi

et al.

Discover Sustainability, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 6, 2025

Nanotechnology has witnessed a paradigm shift with the emergence of sustainable and eco-friendly approach for synthesis Ag/ZnO nanoparticles utilizing various fruit peel extracts. The inherent bioactive compounds present in peels offer green alternative, aligning global efforts toward environmentally responsible nanotechnologies. This not only mitigates environmental impacts but also taps into cost-effective readily available resources nanoparticle synthesis. scope this study encompasses comprehensive exploration substantial utilization applications derived from diverse delves process, considering range sources to optimize characteristics. involves tailoring specific by fine-tuning parameters, diversifying sources, fostering interdisciplinary collaborations. emerging extracts represents transformative nanotechnology. controlled release zinc opens avenues agricultural applications, enhancing nutrient availability plants elevating crop yields. customization catalysis, sensing, optoelectronics highlights their versatility adaptability industrial applications. methodology, grounded principles, far-reaching implications. Embracing pathway ensures optimization more ethical trajectory nanotechnology, contributing well-being both industries environment.

Language: Английский

Citations

3
The cubosome-based nanoplatforms in cancer therapy: Seeking new paradigms for cancer theranostics DOI
B.H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Saad Ali Alshehri

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 116894 - 116894

Published: Aug. 14, 2023

Language: Английский

Citations

28
Unravelling the potential of mitochondria-targeted liposomes for enhanced cancer treatment DOI
Mohammad Sameer Khan, B.H. Jaswanth Gowda, Waleed Hassan Almalki

et al.

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 29(1), P. 103819 - 103819

Published: Nov. 7, 2023

Language: Английский

Citations

28
Aptamer-grafted, cell membrane-coated dendrimer loaded with doxorubicin as a targeted nanosystem against epithelial cellular adhesion molecule (EpCAM) for triple negative breast cancer therapy DOI

Afsana Sheikh,

Mohammed A. S. Abourehab, Alaa S. Tulbah

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 86, P. 104745 - 104745

Published: July 7, 2023

Language: Английский

Citations

24
Photodynamically Tumor Vessel Destruction Amplified Tumor Targeting of Nanoparticles for Efficient Chemotherapy DOI
Peipei Yang, Yunxue Xu,

Xin Zhi

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12933 - 12944

Published: May 7, 2024

Efficient tumor-targeted drug delivery is still a challenging and currently unbreakable bottleneck in chemotherapy for tumors. Nanomedicines based on passive or active targeting strategy have not yet achieved convincing chemotherapeutic benefits the clinic due to tumor heterogeneity. Inspired by efficient inflammatory-cell recruitment acute clots, we constructed two-component nanosystem, which composed of an RGD-modified pyropheophorbide-a (Ppa) micelle (PPRM) that mediates vascular-targeted photodynamic reaction activate local coagulation subsequently transmits signals circulating clot-targeted CREKA peptide-modified camptothecin (CPT)-loaded nanodiscs (CCNDs) amplifying targeting. PPRM could effectively bind with vasculature induce sufficient thrombus reaction. Local reaction-induced target amplification greatly increased accumulation CCND 4.2 times, thus significantly enhancing efficacy 4T1 breast model. In other words, this study provides powerful platform amplify tumor-specific taking advantage crosstalk between PPRM-activated cascade CCND.

Language: Английский

Citations

13