ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(6), С. 6689 - 6708
Опубликована: Фев. 1, 2024
Tumor
development
and
metastasis
are
closely
related
to
the
complexity
of
metabolism
network.
Recently,
reprogramming
strategies
have
attracted
much
attention
in
tumor
therapy.
Although
there
is
preliminary
success
therapy
agents,
their
therapeutic
effects
been
restricted
by
effective
reaching
sites
drugs.
Nanodelivery
systems
with
unique
physical
properties
elaborate
designs
can
specifically
deliver
tumors.
In
this
review,
we
first
summarize
research
progress
nanodelivery
based
on
enhance
therapies
depleting
glucose,
inhibiting
glycolysis,
lactic
acid,
lipid
metabolism,
glutamine
glutathione,
disrupting
metal
metabolisms
combined
other
therapies,
including
chemotherapy,
radiotherapy,
photodynamic
therapy,
etc.
We
further
discuss
detail
advantages
for
As
well
as
opportunities
challenges
integrating
into
analyze
outlook
these
emerging
areas.
This
review
expected
improve
our
understanding
modulating
enhanced
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Март 8, 2024
Ferroptosis
is
a
non-apoptotic
form
of
regulated
cell
death
characterized
by
the
lethal
accumulation
iron-dependent
membrane-localized
lipid
peroxides.
It
acts
as
an
innate
tumor
suppressor
mechanism
and
participates
in
biological
processes
tumors.
Intriguingly,
mesenchymal
dedifferentiated
cancer
cells,
which
are
usually
resistant
to
apoptosis
traditional
therapies,
exquisitely
vulnerable
ferroptosis,
further
underscoring
its
potential
treatment
approach
for
cancers,
especially
refractory
cancers.
However,
impact
ferroptosis
on
extends
beyond
direct
cytotoxic
effect
cells.
induction
not
only
inhibits
but
also
promotes
development
due
negative
anticancer
immunity.
Thus,
comprehensive
understanding
role
crucial
successful
translation
therapy
from
laboratory
clinical
applications.
In
this
review,
we
provide
overview
recent
advancements
cancer,
covering
molecular
mechanisms,
functions,
regulatory
pathways,
interactions
with
microenvironment.
We
summarize
applications
immunotherapy,
radiotherapy,
systemic
therapy,
well
inhibition
various
conditions.
finally
discuss
markers,
current
challenges
future
directions
cancer.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Авг. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Abstract
The
immunological
implications
of
cuproptosis,
a
form
cell
death
highly
sensitive
to
oxygen
presence,
remain
largely
unexplored
in
the
context
tumor
immunotherapy.
Herein,
we
initially
investigate
positive
correlation
between
cuproptosis
and
immunotherapy
through
bioinformatics
analysis.
Subsequently,
an
generator
loaded
with
copper
ions
(
Cu/AP
H‐M)
has
been
constructed,
which
serves
as
effective
carrier
crucially
enhances
oxygenation
microenvironment.
Importantly,
H‐M‐mediated
dual
strengthening
radiotherapy
could
not
only
trigger
powerful
antitumor
immunity
related
immunogenic
by
RNA‐sequencing
analysis,
but
also
effectively
inhibit
growth
both
distal
situ
low
rectal
tumors
after
combined
immunotherapy,
creating
robust
immune
memory
effect.
Our
work
reveals
beneficial
effects
enhanced
radio‐immunotherapy
elucidates
its
underlying
mechanisms,
provides
novel
approach
for
synergistic
integration
radiotherapy,
broadening
scope
cuproptosis‐mediated
therapy.
iScience,
Год журнала:
2024,
Номер
27(6), С. 109979 - 109979
Опубликована: Май 15, 2024
This
review
explores
the
hallmarks
of
cancer
resistance,
including
drug
efflux
mediated
by
ATP-binding
cassette
(ABC)
transporters,
metabolic
reprogramming
characterized
Warburg
effect,
and
dynamic
interplay
between
cells
mitochondria.
The
role
stem
(CSCs)
in
treatment
resistance
regulatory
influence
non-coding
RNAs,
such
as
long
RNAs
(lncRNAs),
microRNAs
(miRNAs),
circular
(circRNAs),
are
studied.
chapter
emphasizes
future
directions,
encompassing
advancements
immunotherapy,
strategies
to
counter
adaptive
integration
artificial
intelligence
for
predictive
modeling,
identification
biomarkers
personalized
treatment.
comprehensive
exploration
these
provides
a
foundation
innovative
therapeutic
approaches,
aiming
navigate
complex
landscape
enhance
patient
outcomes.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 7, 2025
The
advent
of
immune
checkpoint
inhibitors
(ICIs)
in
colorectal
cancer
(CRC)
treatment
marks
a
major
breakthrough.
These
therapies
have
proven
safer
and
more
effective
than
traditional
radiotherapy
targeted
treatments.
Immunotherapies
like
pembrolizumab,
nivolumab,
ipilimumab
pioneered
new
avenues,
potentially
improving
patient
outcomes
quality
life.
Additionally,
advances
immunotherapy
prompted
detailed
research
into
CRC
therapies,
especially
those
integrating
ICIs
with
conventional
treatments,
providing
hope
for
patients
shaping
future
practice.
This
review
delves
the
mechanisms
various
evaluates
their
therapeutic
potential
when
combined
radiotherapy,
chemotherapy,
clinical
settings.
It
also
sheds
light
on
current
application
involving
treatment.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1425 - 1425
Опубликована: Фев. 8, 2025
Ras
proteins
are
pivotal
in
the
regulation
of
cell
proliferation
signals,
and
their
dysregulation
is
intricately
linked
to
pathogenesis
various
malignancies.
Peptide
inhibitors
hold
distinct
advantages
targeting
proteins,
attributable
extensive
binding
domains,
which
result
from
smooth
surfaces
proteins.
The
array
specific
strategies
includes
employment
full
hydrocarbon
chains,
cyclic
peptides,
linear
N-terminal
nucleation
polypeptides.
These
methods
effectively
suppress
signaling
pathway
through
mechanisms,
highlighting
potential
as
anti-neoplastic
agents.
Moreover,
cutting-edge
methodologies,
including
aspartate
strategy
utilization
hydrocarbon-stapled
transforming
landscape
therapeutics
aimed
at
innovations
highlight
promise
peptide
libraries
combinatorial
chemistry
augmenting
affinity,
specificity,
cellular
permeability,
for
development
potent
anti-cancer
incorporation
dual
therapeutic
strategies,
such
synergy
between
conventional
chemotherapy
or
use
radiotherapy
enhancers,
emerges
a
compelling
bolster
efficacy
cancer
treatments
Ras-MAPK
pathway.
Furthermore,
recent
studies
have
demonstrated
that
Ras-targeting
stabilized
peptides
can
amplify
radio-sensitivity
cells,
offering
an
innovative
approach
enhance
radiation
therapy
within
management.
