Ferroptosis: Potential therapeutic targets and prognostic predictions for acute myeloid leukemia (Review) DOI Open Access
Wenlu Zhang, Wen Wen,

Ran Tan

и другие.

Oncology Letters, Год журнала: 2024, Номер 28(6)

Опубликована: Сен. 30, 2024

Ferroptosis is a relatively recently discovered type of regulated cell death that induced by iron-dependent lipid peroxidation. The key contributing factors to ferroptosis are the loss glutathione peroxidase 4 which required for reversing peroxidation, buildup redox-active iron and oxidation phospholipids containing polyunsaturated fatty acids. has been associated with number diseases, including cancers such as hepatocellular carcinoma, breast cancer, acute renal damage neurological disorders Alzheimer's disease disease, there may be an association between myeloid leukemia (AML). present review aims describe primary regulatory pathways ferroptosis, relationship occurrence development AML. Furthermore, comprehensively summarizes latest advances in treatment prognosis

Язык: Английский

Cross-talks of GSH, mitochondria, RNA m6A modification, NRF2, and p53 between ferroptosis and cuproptosis in HCC: A review DOI

Leihan Wang,

Zhenni ChenLiu,

Daorong Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 302, С. 140523 - 140523

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

2
Targeting GPX4 in ferroptosis and cancer: chemical strategies and challenges DOI
Jiao Liu, Daolin Tang, Rui Kang

и другие.

Trends in Pharmacological Sciences, Год журнала: 2024, Номер 45(8), С. 666 - 670

Опубликована: Июнь 12, 2024

Язык: Английский

Процитировано

15
Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy DOI
Weijia Wang,

Behishta Hashimi,

Ping Wang

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Язык: Английский

Процитировано

1
Ferroptosis: CD8+T cells’ blade to destroy tumor cells or poison for self-destruction DOI Creative Commons
Yuan Liang, Yixin Zhao, Zhili Qi

и другие.

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 1, 2025

Abstract Ferroptosis represents an emerging, iron-dependent form of cell death driven by lipid peroxidation. In recent years, it has garnered significant attention in the realm cancer immunotherapy, particularly studies involving immune checkpoint inhibitors. This not only enhances our comprehension tumor microenvironment but is also considered a promising therapeutic strategy to address resistance, investigate activation mechanisms, and facilitate development vaccines. The combination immunotherapy with ferroptosis provides innovative targets fresh perspectives for advancing treatment. Nevertheless, cells appear possess wider array evasion strategies compared CD8 + T cells, which have been conclusively shown be more vulnerable ferroptosis. Furthermore, TME can create favorable environment survival invasion. Under this premise, both inducing inhibiting will impact antitumor immunity some extent, even make final result run counter purpose. paper systematically elucidates dual-edged sword role process briefly outlining complexity within TME. It explores potential side effects associated ferroptosis-inducing therapies critically considers combined application ferroptosis-based ICIs. highlights current challenges faced approach points out future directions development.

Язык: Английский

Процитировано

1
Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects DOI
Y. F. Lu,

Xiao‐Ting Xie,

Lianxiang Luo

и другие.

APOPTOSIS, Год журнала: 2024, Номер 29(11-12), С. 1914 - 1943

Опубликована: Июль 15, 2024

Язык: Английский

Процитировано

7
NFE2L2 and ferroptosis resistance in cancer therapy DOI Open Access
Daolin Tang, Rui Kang

Cancer Drug Resistance, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

NFE2-like basic leucine zipper transcription factor 2 (NFE2L2, also known as NRF2), is a key in the cellular defense against oxidative stress, playing crucial role cancer cell survival and resistance to therapies. This review outlines current knowledge on link between NFE2L2 ferroptosis - form of regulated death characterized by iron-dependent lipid peroxidation within cells. While activation can protect normal cells from damage, its overexpression contributes drug upregulating antioxidant defenses inhibiting ferroptosis. We delve into molecular pathways ferroptosis, highlighting involvement target genes, such

Язык: Английский

Процитировано

6
Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells DOI Creative Commons
Chengwu Zeng, Dingrui Nie, Xianfeng Wang

и другие.

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Окт. 28, 2024

In the ongoing battle against BCR-ABL+ leukemia, despite significant advances with tyrosine kinase inhibitors (TKIs), persistent challenges of drug resistance and enduring presence leukemic stem cells (LSCs) remain formidable barriers to achieving a cure. this study, we demonstrated that Disulfiram (DSF) induces ferroptosis synergize TKIs in inhibiting cells, particularly targeting resistant LSCs, using cell models, mouse primary from patients. We elucidated mechanism by which DSF promotes GPX4 degradation induce through immunofluorescence, co-immunoprecipitation (CO-IP), RNA sequencing, lipid peroxidation assays, rescue experiments. Here, present compelling evidence elucidating sensitivity DSF, an USA FDA-approved for alcohol dependence, towards cells. Our findings underscore DSF's ability selectively potent cytotoxic effect on lines effectively inhibit leukemia Crucially, combined treatment eradicates TKI-insensitive Of particular note is capacity disrupt stability, elevate labile iron pool, intensify peroxidation, ultimately leading ferroptotic death. investigation shows BCR-ABL expression alterations cellular metabolism increases expression. Additionally, demonstrate indispensability LSC development initiation/maintenance leukemia. Mechanical analysis further elucidates overcome reducing levels disruption its binding HSPA8, thereby promoting STUB1-mediated ubiquitination subsequent proteasomal degradation. Furthermore, targets both blast drug-insensitive conferring survival advantage models. summary, dual inhibition presents promising therapeutic strategy synergistically target LSCs patients, offering potential avenues advancing treatment.

Язык: Английский

Процитировано

5
Pan-gastrointestinal adenocarcinoma analysis uncovers the prognostic and immune correlates of ferroptosis-related genes DOI Open Access

Xiaochuan Dong,

Yanyan Xie, Wenxi Chen

и другие.

Translational Gastroenterology and Hepatology, Год журнала: 2025, Номер 10, С. 7 - 7

Опубликована: Янв. 1, 2025

Gastrointestinal adenocarcinomas (GIACs) are common malignant tumors with poor prognosis in the world. Ferroptosis, characterized by accumulation of intracellular iron and lipid reactive oxygen species, emerges as a pivotal process tumorigenesis cancer advancement. However, implications ferroptosis-related genes GIAC remain to be elucidated. This study aimed at exploring potential role on treatment GIAC. In our study, comprehensive clinical, transcriptomic, and/or genomic data were acquired from The Cancer Genome Atlas (TCGA), Cell Line Encyclopedia (CCLE), Genomics Drug Sensitivity (GDSC), Gene Expression Omnibus (GEO). We formulated ferroptosis-score within TCGA cohort through gene set variation analysis (GSVA) subsequently validated 4 GEO datasets (GSE84437, GSE17536, GSE103479, GSE19417). sensitivity immunotherapy efficacy analyzed GDSC dataset PRJEB25780 cohort, respectively. was significantly associated favorable overall survival both training [TCGA: P=0.003; hazard ratio (HR), 0.67, 95% confidence interval (95% CI): 0.52-0.87] across four validation cohorts (GSE17536: P=0.03; HR, 0.57, CI: 0.34-0.96; GSE19417: P=0.047; 0.53, 0.28-1.01; GSE84437: P=0.004; 0.68, 0.51-0.90; GSE103479: 0.55, 0.32-0.96). Furthermore, correlated activation DNA damage repair pathway resistance cisplatin. Notably, GIACs low ferroptosis-scores exhibited heightened expression immune checkpoint molecules such programmed death-(ligand) 1 cytotoxic T lymphocyte antigen-4, elevated densities tumor-infiltrating CD8+ cells, response pembrolizumab monotherapy. Our findings delineated clinical relevance demonstrated utility predicting effectiveness.

Язык: Английский

Процитировано

0
Tumor-derived miR-203a-3p potentiates muscle wasting by inducing muscle ferroptosis in pancreatic cancer DOI

Yumeng Hu,

Yifu Hu,

Shaobo Zhang

и другие.

Cancer Letters, Год журнала: 2025, Номер 614, С. 217523 - 217523

Опубликована: Фев. 6, 2025

Язык: Английский

Процитировано

0
The Dynamic Role of Ferroptosis in Cancer Immunoediting: Implications for Immunotherapy DOI Creative Commons
Jun Lan, Dan Cai,

Shuang Gou

и другие.

Pharmacological Research, Год журнала: 2025, Номер 214, С. 107674 - 107674

Опубликована: Фев. 27, 2025

Currently, cancer immunotherapy strategies are primarily formulated based on the patient's present condition, representing a "static" treatment approach. However, progression is inherently "dynamic," as immune environment not fixed but undergoes continuous changes. This dynamism characterized by ongoing interactions between tumor cells and cells, which ultimately lead to alterations in microenvironment. process can be effectively elucidated concept of immunoediting, divides development into three phases: "elimination," "equilibrium," "escape." Consequently, adjusting regimens these distinct phases may enhance patient survival improve prognosis. Targeting ferroptosis an emerging area immunotherapy, our findings reveal that antioxidant systems associated with possess dual roles, functioning differently across immunoediting. Therefore, this review delve role system progression. It also propose targeting at different stages, aiming illuminate significant implications various for immunotherapy.

Язык: Английский

Процитировано

0