Experimental Cell Research, Год журнала: 2022, Номер 418(2), С. 113274 - 113274
Опубликована: Июль 8, 2022
Язык: Английский
International Immunopharmacology, Год журнала: 2022, Номер 106, С. 108634 - 108634
Опубликована: Фев. 19, 2022
Язык: Английский
Процитировано
81
Gels, Год журнала: 2023, Номер 9(5), С. 373 - 373
Опубликована: Май 1, 2023
Chitosan hydrogels have a wide range of applications in tissue engineering scaffolds, mainly due to the advantages their chemical and physical properties. This review focuses on application chitosan scaffolds for vascular regeneration. We introduced these following aspects: progress regeneration modification improve Finally, this paper discusses prospects
Язык: Английский
Процитировано
49
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Июнь 6, 2024
Abstract Adipose-derived stem cells (ADSCs) are a subset of mesenchymal (MSCs) isolated from adipose tissue. They possess remarkable properties, including multipotency, self-renewal, and easy clinical availability. ADSCs also capable promoting tissue regeneration through the secretion various cytokines, factors, extracellular vesicles (EVs). ADSC-derived EVs (ADSC-EVs) act as intercellular signaling mediators that encapsulate range biomolecules. These have been found to mediate therapeutic activities donor by proliferation migration effector cells, facilitating angiogenesis, modulating immunity, performing other specific functions in different tissues. Compared themselves, ADSC-EVs offer advantages such fewer safety concerns more convenient transportation storage for application. As result, these received significant attention cell-free agents with potential future application regenerative medicine. In this review, we focus on recent research progress regarding medical use across conditions, wound healing, chronic limb ischemia, myocardial infarction, diabetic nephropathy, fat graft survival, bone regeneration, cartilage tendinopathy tendon peripheral nerve acute lung injury, among others. We discuss underlying mechanisms responsible inducing effects. believe deciphering biological effects, associated will provide foundation developing novel approach Graphical
Язык: Английский
Процитировано
26
Periodontology 2000, Год журнала: 2024, Номер 94(1), С. 257 - 414
Опубликована: Фев. 1, 2024
Abstract Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with ability to communicate other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due their be utilized as therapeutic options for a wide array diseases/conditions. Over 5000 publications currently being published yearly on this topic, number is only expected dramatically increase novel strategies continue developed. Today exosomes have been applied numerous contexts including neurodegenerative disorders (Alzheimer's disease, central nervous system, depression, multiple sclerosis, Parkinson's post‐traumatic stress disorders, traumatic brain injury, peripheral nerve injury), damaged organs (heart, kidney, liver, stroke, myocardial infarctions, ovaries), degenerative processes (atherosclerosis, diabetes, hematology musculoskeletal degeneration, osteoradionecrosis, respiratory disease), infectious diseases (COVID‐19, hepatitis), procedures (antiaging, bone regeneration, cartilage/joint osteoarthritis, cutaneous wounds, dental dermatology/skin erectile dysfunction, hair regrowth, intervertebral disc repair, spinal cord vascular regeneration), cancer therapy (breast, colorectal, gastric osteosarcomas), immune function (allergy, autoimmune regulation, inflammatory diseases, lupus, rheumatoid arthritis). This scoping review first its kind aimed at summarizing extensive potential broad range disorders.
Язык: Английский
Процитировано
21
Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 23, 2025
Articular cartilage injuries can lead to pain, stiffness, and reduced mobility, may eventually progress osteoarthritis (OA). Despite substantial research efforts, effective therapies capable of regenerating are still lacking. Mesenchymal stromal cells (MSCs) known for their differentiation immunomodulatory capabilities, yet challenges such as limited survival post-injection inconsistent therapeutic outcomes hinder clinical application. Recent evidence suggests that the beneficial effects MSCs largely mediated by secreted small extracellular vesicles (sEVs), which have been shown promote tissue repair reduce inflammation. MSC-derived sEVs promise in mitigating degradation chondrocyte apoptosis, positioning them a promising alternative MSC-based OA treatment. This review explores potential limitations regeneration. systematic was conducted following PRISMA guidelines, with comprehensive search Web Science Scopus databases studies published between 2019 2024. A total 223 records were identified, 132 articles assessed eligibility based on general selection criteria. After full-text screening, 60 initially selected, comprising 58 vitro 40 vivo studies. Following further exclusion specific criteria, 33 28 from 47 scientific papers included final qualitative synthesis. Most indicate enhance proliferation, improve matrix composition, matrix-degrading enzymes inflammation, thereby delaying progression. growing body supports use tool preventing progression, most reporting structure function. However, remain optimizing standardizing isolation, dosage, delivery methods Further is necessary elucidate mechanisms underlying sEVs-mediated regeneration facilitate translation into therapies.
Язык: Английский
Процитировано
3
Bioactive Materials, Год журнала: 2022, Номер 22, С. 423 - 452
Опубликована: Окт. 20, 2022
Osteoarthritis (OA) is a highly prevalent whole-joint disease that causes disability and pain affects patient's quality of life. However, currently, there lack effective early diagnosis treatment. Although stem cells can promote cartilage repair treat OA, problems such as immune rejection tumorigenicity persist. Extracellular vesicles (EVs) transmit genetic information from donor mediate intercellular communication, which considered functional paracrine factor cells. Increasing evidences suggest EVs may play an essential complex role in the pathogenesis, diagnosis, treatment OA. Here, we introduced OA progression by influencing inflammation, metabolism, aging. Next, discussed blood, synovial fluid, joint-related for diagnosis. Moreover, outlined potential modified unmodified their combination with biomaterials therapy. Finally, discuss deficiencies put forward prospects challenges related to application field
Язык: Английский
Процитировано
63
Frontiers in Endocrinology, Год журнала: 2022, Номер 13
Опубликована: Окт. 28, 2022
Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of articular cartilage, inflammation, and changes in periarticular subchondral bone joints. Osteoporosis (OP) another systemic skeletal low mass mineral density (BMD) accompanied microarchitectural deterioration tissue increased fragility fracture risk. Both OA OP are mainly affected on elderly people. Recent studies have shown that osteopontin (OPN) plays a vital role metabolism homeostasis. OPN involves these biological activities through participating proliferation, migration, differentiation, adhesion several bone-related cells, including chondrocytes, synoviocytes, osteoclasts, osteoblasts, marrow mesenchymal stem cells (MSCs). has been demonstrated to be closely related occurrence development many diseases, such as OP. This review summarizes regulating inflammation activity Furthermore, some drugs targeted treat also summarized review. However, complex mechanism not fully elucidated, which drives us explore depth effect two diseases.
Язык: Английский
Процитировано
48
Chemical Reviews, Год журнала: 2023, Номер 123(19), С. 11559 - 11618
Опубликована: Сен. 27, 2023
With the growing demand for next-generation health care, integration of electronic components into implantable medical devices (IMDs) has become a vital factor in achieving sophisticated healthcare functionalities such as electrophysiological monitoring and electroceuticals worldwide. However, these confront technological challenges concerning noninvasive power supply biosafe device removal. Addressing is crucial to ensure continuous operation patient comfort minimize physical economic burden on system. This Review highlights promising capabilities bioresorbable triboelectric nanogenerators (B-TENGs) temporary self-clearing sources self-powered IMDs. First, we present an overview progress energy harvesting devices, focusing their working principles, materials development, biodegradation mechanisms. Next, examine current state on-demand transient implants biomedical applications. Finally, address future perspectives B-TENGs, aimed at expanding scope developing innovative solutions. discusses advancements science, chemistry, microfabrication that can advance solutions available These innovations potentially change paradigm, contribute enhanced longevity, reshape landscape soon.
Язык: Английский
Процитировано
39
Ageing Research Reviews, Год журнала: 2023, Номер 85, С. 101864 - 101864
Опубликована: Янв. 25, 2023
Язык: Английский
Процитировано
33
Journal of Controlled Release, Год журнала: 2023, Номер 355, С. 685 - 708
Опубликована: Фев. 19, 2023
Extracellular vesicles (EVs) are a population of small secreted by essentially all cell types, containing wide variety biological macromolecules. Due to their intrinsic capabilities for efficient intercellular communication, they involved in various aspects cellular functioning. In the past decade, EVs derived from stem cells attracted interest field regenerative medicine. Owing properties, have great potential use tissue repair, particular tissues with limited such as cartilage. The maintenance articular cartilage is dependent on precarious balance many different components that can be disrupted onset prevalent rheumatic diseases. However, while strong mechanical properties withstand movement and heavy loads years, it virtually incapable repairing itself after damage has occurred. Stem cell-derived (SC-EVs) transport proteins nucleic acids parental recipient cells, thereby promoting healing. Many possible pathways through which SC-EVs execute function been reported, but likely there still numerous other unknown. This review discusses preclinical studies investigating intra-articular injections free SC-EVs, which, often chondrogenesis repair vivo, showed recurring limitation need multiple administrations achieve sufficient regeneration. Potentially, this drawback overcome making an EV delivery platform capable sustainably releasing over time. With remarkable versatility favourable chemical, hydrogels facilitate release profile encapsulating porous structure. Ideally, optimal formed in-situ, means injectable hydrogel administered directly into affected joint. Relevant research fulfilling these criteria discussed detail, including steps taken before sustained applied context regeneration clinic.
Язык: Английский
Процитировано
28