International Journal of Pharmaceutics, Год журнала: 2024, Номер 652, С. 123865 - 123865
Опубликована: Янв. 28, 2024
Язык: Английский
Cancers, Год журнала: 2023, Номер 15(3), С. 585 - 585
Опубликована: Янв. 18, 2023
Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic (PDT), non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance therapy, but some unavoidable disadvantages, including limited light penetration depth, poor tumor selectivity, as well oxygen dependence, largely limit its efficiency for solid tumors treatment. Thus, strategies gone into overcoming these obstacles, such exploring new photosensitizers with higher conversion efficiency, alleviating hypoxia to fuel generation of reactive species (ROS), designing tumor-targeted PS, and applying PDT-based combination strategies. In this review, briefly summarized related approaches, which are mainly characterized by advanced PSs, PSs excellent additional refreshing features. We also summarize therapies effects.
Язык: Английский
Процитировано
138
International Journal of Nanomedicine, Год журнала: 2022, Номер Volume 17, С. 6427 - 6446
Опубликована: Дек. 1, 2022
Photoactivation therapy based on photodynamic (PDT) and photothermal (PTT) has been identified as a tumour ablation modality for numerous cancer indications, with photosensitisers conversion agents playing important roles in the phototherapy process, especially recent decades.In addition, iteration of nanotechnology strongly promoted development treatment.PDT can increase sensitivity cells to PTT by interfering microenvironment, whereas heat generated blood flow, improve oxygen supply enhance PDT therapeutic effect.In cell debris serve tumour-associated antigens, evoking antitumor immune responses.In this review, research progress phototherapy, its effects combination immunotherapy treatment tumours are mainly outlined, issues that may need continued attention future raised.
Язык: Английский
Процитировано
101
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Март 22, 2023
Abstract Osteosarcoma, the most common malignant tumor of bone, seriously influences people’s lives and increases their economic burden. Conventional chemotherapy drugs achieve limited therapeutic effects owing to poor targeting severe systemic toxicity. Nanocarrier-based drug delivery systems can significantly enhance utilization efficiency chemotherapeutic through ligand modifications reduce occurrence adverse effects. A variety ligand-modified nano-drug have been developed for different schemes. Here we review biological characteristics main challenges current therapy OS, further elaborate on schemes selection osteosarcoma, which may provide new horizons development advanced targeted in future.
Язык: Английский
Процитировано
81
MedComm, Год журнала: 2024, Номер 5(7)
Опубликована: Июнь 22, 2024
Photodynamic therapy (PDT) is a temporally and spatially precisely controllable, noninvasive, potentially highly efficient method of phototherapy. The three components PDT primarily include photosensitizers, oxygen, light. employs specific wavelengths light to active photosensitizers at the tumor site, generating reactive oxygen species that are fatal cells. Nevertheless, traditional have disadvantages such as poor water solubility, severe oxygen-dependency, low targetability, difficult penetrate deep tissue, which remains toughest task in application clinic. Here, we systematically summarize development molecular mechanisms challenges management, highlighting advantages nanocarriers-based against cancer. third generation has opened up new horizons PDT, cooperation between nanocarriers attained satisfactory achievements. Finally, clinical studies discussed. Overall, present an overview our perspective field believe this work will provide insight into tumor-based PDT.
Язык: Английский
Процитировано
32
Small, Год журнала: 2024, Номер 20(26)
Опубликована: Янв. 14, 2024
Abstract Ferroptosis, a novel form of nonapoptotic cell death, can effectively enhance photodynamic therapy (PDT) performance by disrupting intracellular redox homeostasis and promoting apoptosis. However, the extremely hypoxic tumor microenvironment (TME) together with highly expressed hypoxia‐inducible factor‐1α (HIF‐1α) presents considerable challenge for clinical PDT against osteosarcoma (OS). Hence, an innovative nanoplatform that enhances antitumor inducing ferroptosis alleviating hypoxia is fabricated. Capsaicin (CAP) widely reported to specifically activate transient receptor potential vanilloid 1 (TRPV1) channel, trigger increase in Ca 2+ concentration, which closely linked ferroptosis, participate decreased oxygen consumption inhibiting HIF‐1α cells, potentiating efficiency. Thus, CAP photosensitizer IR780 are coencapsulated into biocompatible human serum albumin (HSA) construct (CI@HSA NPs) synergistic treatment under near‐infrared (NIR) irradiation. Furthermore, underlying signaling pathways combination investigated. CI@HSA NPs achieve real‐time dynamic distribution monitoring exhibit excellent efficacy superior biosafety vivo. Overall, this work highlights promising NIR imaging‐guided “pro‐death” strategy overcome limitations OS hypoxia, providing inspiration support future approaches.
Язык: Английский
Процитировано
21
RSC Advances, Год журнала: 2024, Номер 14(15), С. 10608 - 10637
Опубликована: Янв. 1, 2024
This review summarized the function of cancer cell membranes and comprehensively discussed preparation membrane-coated nanoparticles (CCM-NPs) their application in anti-tumor therapy. The graphical abstract figure was drawn by Figdraw (https://www.figdraw.com).
Язык: Английский
Процитировано
21
Asian Journal of Pharmaceutical Sciences, Год журнала: 2023, Номер 18(4), С. 100829 - 100829
Опубликована: Июль 1, 2023
Current antitumor monotherapy has many limitations, highlighting the need for novel synergistic anticancer strategies. Ferroptosis is an iron-dependent form of nonapoptotic cell death that plays a pivotal regulatory role in tumorigenesis and treatment. Photodynamic therapy (PDT) causes irreversible chemical damage to target lesions widely used therapy. However, PDT's effectiveness usually hindered by several obstacles, such as hypoxia, excess glutathione (GSH), tumor resistance. improves efficacy PDT increasing oxygen reactive species (ROS) or reducing GSH levels, also enhances ferroptosis induction due ROS effect microenvironment (TME). Strategies based on nanoparticles (NPs) can subtly exploit potential synergy PDT. This review explores recent advances current challenges landscape underlying mechanisms regulating PDT, well nano delivery system-mediated activity. These include polymers, biomimetic materials, metal organic frameworks (MOFs), inorganics, carrier-free NPs. Finally, we highlight future perspectives this emerging paradigm targeted cancer therapies.
Язык: Английский
Процитировано
38
Advanced Science, Год журнала: 2023, Номер 10(24)
Опубликована: Июнь 17, 2023
Bone diseases including bone defects, infections, osteoarthritis, and tumors seriously affect life quality of the patient bring serious economic burdens to social health management, for which current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial-based strategies have been widely applied in treatment orthopedic but are still plagued by deficient bioreactivity. With development nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, excellent drug loading delivery capabilities arise widespread attention achieved considerable achievements disease last decade. However, authors' best knowledge, no review has comprehensively summarized advances LDHs treating so far. Herein, advantages disorders outlined corresponding state-of-the-art first time. The potential LDHs-based nanocomposites extended therapeutics is highlighted perspectives scaffold design proposed facilitated translation.
Язык: Английский
Процитировано
37
Cell Death Discovery, Год журнала: 2023, Номер 9(1)
Опубликована: Дек. 18, 2023
Ferritinophagy, a process involving selective autophagy of ferritin facilitated by nuclear receptor coactivator 4 (NCOA4), entails the recognition NCOA4 and subsequent delivery to autophagosome. Within autophagosome, undergoes degradation, leading release iron in lysosome. It is worth noting that excessive levels can trigger cell death. Recent evidence has elucidated significant roles played ferritinophagy ferroptosis regulation initiation progression cancer. Given crucial role tumor biology, it may serve as potential target for future anti-tumor therapeutic interventions. In this study, we have provided distinctive features its distinctions from ferroptosis. Moreover, briefly examined fundamental regulatory mechanisms ferritinophagy, encompassing involvement specific NCOA4, Nrf2/HO-1 signaling other pathways. Subsequently, synthesized current understanding impact on cancer applications, with particular emphasis utilization chemotherapy, nanomaterials, immunotherapy pathway purposes.
Язык: Английский
Процитировано
29
Coordination Chemistry Reviews, Год журнала: 2023, Номер 500, С. 215532 - 215532
Опубликована: Ноя. 10, 2023
Язык: Английский
Процитировано
26