The Current Status of Photodynamic Therapy in Cancer Treatment

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 585 - 585

Published: Jan. 18, 2023

Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic (PDT), non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance therapy, but some unavoidable disadvantages, including limited light penetration depth, poor tumor selectivity, as well oxygen dependence, largely limit its efficiency for solid tumors treatment. Thus, strategies gone into overcoming these obstacles, such exploring new photosensitizers with higher conversion efficiency, alleviating hypoxia to fuel generation of reactive species (ROS), designing tumor-targeted PS, and applying PDT-based combination strategies. In this review, briefly summarized related approaches, which are mainly characterized by advanced PSs, PSs excellent additional refreshing features. We also summarize therapies effects.

Language: Английский

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Combined Photodynamic and Photothermal Therapy and Immunotherapy for Cancer Treatment: A Review

International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 6427 - 6446

Published: Dec. 1, 2022

Photoactivation therapy based on photodynamic (PDT) and photothermal (PTT) has been identified as a tumour ablation modality for numerous cancer indications, with photosensitisers conversion agents playing important roles in the phototherapy process, especially recent decades.In addition, iteration of nanotechnology strongly promoted development treatment.PDT can increase sensitivity cells to PTT by interfering microenvironment, whereas heat generated blood flow, improve oxygen supply enhance PDT therapeutic effect.In cell debris serve tumour-associated antigens, evoking antitumor immune responses.In this review, research progress phototherapy, its effects combination immunotherapy treatment tumours are mainly outlined, issues that may need continued attention future raised.

Language: Английский

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Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: March 22, 2023

Abstract Osteosarcoma, the most common malignant tumor of bone, seriously influences people’s lives and increases their economic burden. Conventional chemotherapy drugs achieve limited therapeutic effects owing to poor targeting severe systemic toxicity. Nanocarrier-based drug delivery systems can significantly enhance utilization efficiency chemotherapeutic through ligand modifications reduce occurrence adverse effects. A variety ligand-modified nano-drug have been developed for different schemes. Here we review biological characteristics main challenges current therapy OS, further elaborate on schemes selection osteosarcoma, which may provide new horizons development advanced targeted in future.

Language: Английский

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Photodynamic therapy for cancer: mechanisms, photosensitizers, nanocarriers, and clinical studies

MedComm, Journal Year: 2024, Volume and Issue: 5(7)

Published: June 22, 2024

Photodynamic therapy (PDT) is a temporally and spatially precisely controllable, noninvasive, potentially highly efficient method of phototherapy. The three components PDT primarily include photosensitizers, oxygen, light. employs specific wavelengths light to active photosensitizers at the tumor site, generating reactive oxygen species that are fatal cells. Nevertheless, traditional have disadvantages such as poor water solubility, severe oxygen-dependency, low targetability, difficult penetrate deep tissue, which remains toughest task in application clinic. Here, we systematically summarize development molecular mechanisms challenges management, highlighting advantages nanocarriers-based against cancer. third generation has opened up new horizons PDT, cooperation between nanocarriers attained satisfactory achievements. Finally, clinical studies discussed. Overall, present an overview our perspective field believe this work will provide insight into tumor-based PDT.

Language: Английский

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Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform

RSC Advances, Journal Year: 2024, Volume and Issue: 14(15), P. 10608 - 10637

Published: Jan. 1, 2024

This review summarized the function of cancer cell membranes and comprehensively discussed preparation membrane-coated nanoparticles (CCM-NPs) their application in anti-tumor therapy. The graphical abstract figure was drawn by Figdraw (https://www.figdraw.com).

Language: Английский

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Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro‐Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia

Small, Journal Year: 2024, Volume and Issue: 20(26)

Published: Jan. 14, 2024

Abstract Ferroptosis, a novel form of nonapoptotic cell death, can effectively enhance photodynamic therapy (PDT) performance by disrupting intracellular redox homeostasis and promoting apoptosis. However, the extremely hypoxic tumor microenvironment (TME) together with highly expressed hypoxia‐inducible factor‐1α (HIF‐1α) presents considerable challenge for clinical PDT against osteosarcoma (OS). Hence, an innovative nanoplatform that enhances antitumor inducing ferroptosis alleviating hypoxia is fabricated. Capsaicin (CAP) widely reported to specifically activate transient receptor potential vanilloid 1 (TRPV1) channel, trigger increase in Ca 2+ concentration, which closely linked ferroptosis, participate decreased oxygen consumption inhibiting HIF‐1α cells, potentiating efficiency. Thus, CAP photosensitizer IR780 are coencapsulated into biocompatible human serum albumin (HSA) construct (CI@HSA NPs) synergistic treatment under near‐infrared (NIR) irradiation. Furthermore, underlying signaling pathways combination investigated. CI@HSA NPs achieve real‐time dynamic distribution monitoring exhibit excellent efficacy superior biosafety vivo. Overall, this work highlights promising NIR imaging‐guided “pro‐death” strategy overcome limitations OS hypoxia, providing inspiration support future approaches.

Language: Английский

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Nanoparticle-mediated synergistic anticancer effect of ferroptosis and photodynamic therapy: novel insights and perspectives

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(4), P. 100829 - 100829

Published: July 1, 2023

Current antitumor monotherapy has many limitations, highlighting the need for novel synergistic anticancer strategies. Ferroptosis is an iron-dependent form of nonapoptotic cell death that plays a pivotal regulatory role in tumorigenesis and treatment. Photodynamic therapy (PDT) causes irreversible chemical damage to target lesions widely used therapy. However, PDT's effectiveness usually hindered by several obstacles, such as hypoxia, excess glutathione (GSH), tumor resistance. improves efficacy PDT increasing oxygen reactive species (ROS) or reducing GSH levels, also enhances ferroptosis induction due ROS effect microenvironment (TME). Strategies based on nanoparticles (NPs) can subtly exploit potential synergy PDT. This review explores recent advances current challenges landscape underlying mechanisms regulating PDT, well nano delivery system-mediated activity. These include polymers, biomimetic materials, metal organic frameworks (MOFs), inorganics, carrier-free NPs. Finally, we highlight future perspectives this emerging paradigm targeted cancer therapies.

Language: Английский

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Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Advanced Science, Journal Year: 2023, Volume and Issue: 10(24)

Published: June 17, 2023

Bone diseases including bone defects, infections, osteoarthritis, and tumors seriously affect life quality of the patient bring serious economic burdens to social health management, for which current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial-based strategies have been widely applied in treatment orthopedic but are still plagued by deficient bioreactivity. With development nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, excellent drug loading delivery capabilities arise widespread attention achieved considerable achievements disease last decade. However, authors' best knowledge, no review has comprehensively summarized advances LDHs treating so far. Herein, advantages disorders outlined corresponding state-of-the-art first time. The potential LDHs-based nanocomposites extended therapeutics is highlighted perspectives scaffold design proposed facilitated translation.

Language: Английский

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Ferritinophagy: research advance and clinical significance in cancers

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Dec. 18, 2023

Ferritinophagy, a process involving selective autophagy of ferritin facilitated by nuclear receptor coactivator 4 (NCOA4), entails the recognition NCOA4 and subsequent delivery to autophagosome. Within autophagosome, undergoes degradation, leading release iron in lysosome. It is worth noting that excessive levels can trigger cell death. Recent evidence has elucidated significant roles played ferritinophagy ferroptosis regulation initiation progression cancer. Given crucial role tumor biology, it may serve as potential target for future anti-tumor therapeutic interventions. In this study, we have provided distinctive features its distinctions from ferroptosis. Moreover, briefly examined fundamental regulatory mechanisms ferritinophagy, encompassing involvement specific NCOA4, Nrf2/HO-1 signaling other pathways. Subsequently, synthesized current understanding impact on cancer applications, with particular emphasis utilization chemotherapy, nanomaterials, immunotherapy pathway purposes.

Language: Английский

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Self-assembled albumin nanoparticles induce pyroptosis for photodynamic/photothermal/immuno synergistic therapies in triple-negative breast cancer

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 25, 2023

Triple-negative breast cancer (TNBC) is characterized by a high degree of malignancy, early metastasis, limited treatment, and poor prognosis. Immunotherapy, as new most promising treatment for cancer, has efficacy in TNBC because the immunosuppressive tumor microenvironment (TME). Inducing pyroptosis activating cyclic guanosine monophosphate-adenosine monophosphate synthase/interferon gene stimulator (cGAS/STING) signaling pathway to upregulate innate immunity have become an emerging strategy enhancing immunotherapy. In this study, albumin nanospheres were constructed with photosensitizer-IR780 encapsulated core cGAS–STING agonists/H 2 S producer-ZnS loaded on shell (named IR780-ZnS@HSA). vitro , IR780-ZnS@HSA produced photothermal therapy (PTT) photodynamic (PDT) effects. addition, it stimulated immunogenic cell death (ICD) activated cells via caspase-3–GSDME pathway. also The two pathways synergistically boost immune response. vivo + laser significantly inhibited growth 4T1 tumor-bearing mice triggered response, improving anti-APD-L1 antibody (aPD-L1). conclusion, IR780-ZnS@HSA, novel inducer pyroptosis, can inhibit improve aPD-L1.

Language: Английский

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