Journal of Controlled Release,
Год журнала:
2024,
Номер
371, С. 146 - 157
Опубликована: Май 29, 2024
Ultrasound
is
widely
used
in
the
diagnosis
and
therapy
of
cancer.
Tumors
can
be
treated
by
thermal
or
mechanical
tissue
ablation.
Furthermore,
tumors
manipulated
hyperthermia,
sonodynamic
sonoporation,
e.g.,
increasing
tumor
perfusion
permeability
biological
barriers
to
enhance
drug
delivery.
These
treatments
induce
various
immune
responses
tumors.
However,
conflicting
data
high
heterogeneity
between
experimental
settings
make
it
difficult
generalize
effects
ultrasound
on
immunity.
Therefore,
we
performed
a
systematic
review
answer
question:
"Does
alter
reaction
peripheral
solid
humans
animals
compared
control
conditions
without
ultrasound?"
A
literature
search
was
PubMed,
EMBASE,
Web
Science
24,401
potentially
relevant
publications
were
identified.
Of
these,
96
eligible
for
inclusion
review.
Experiments
humans,
rats,
mice
focused
different
types,
primarily
breast
melanoma.
We
collected
non-thermal
settings,
use
sono-sensitizers
sono-enhancers,
anti-tumor
therapies.
Six
meta-analyses
quantify
effect
infiltration
T
cells
(cytotoxic,
helper,
regulatory
cells)
blood
cytokines
(interleukin-6,
interferon-γ,
necrosis
factor-α).
provide
robust
scientific
evidence
that
alters
cell
into
increases
cytokine
concentrations.
identified
significant
differences
based
type,
mouse
age.
Stronger
observed
using
hyperthermia
combination
with
young
mice.
The
latter
may
impair
translational
impact
study
results
as
most
cancer
patients
are
older.
Thus,
our
help
refining
parameters
therapeutic
minimize
diagnostic
applications.
Cancer
immunotherapy
effect
can
be
greatly
enhanced
by
other
methods
to
induce
immunogenic
cell
death
(ICD),
which
has
profoundly
affected
as
a
highly
efficient
paradigm.
However,
these
treatments
have
significant
limitations,
either
causing
damage
of
the
immune
system
or
limited
superficial
tumors.
Sonodynamic
therapy
(SDT)
ICD
promote
without
affecting
because
its
excellent
spatiotemporal
selectivity
and
low
side
effects.
Nevertheless,
SDT
is
still
reactive
oxygen
species
yield
complex
tumor
microenvironment.
Recently,
some
emerging
SDT-based
nanomedicines
made
numerous
attractive
encouraging
achievements
in
field
cancer
due
high
immunotherapeutic
efficiency.
this
cross-cutting
research
far
from
being
widely
explored
huge
professional
barriers.
Herein,
characteristics
microenvironment
mechanisms
are
firstly
systematically
summarized.
Subsequently,
therapeutic
mechanism
fully
summarized,
advantages
limitations
discussed.
The
representative
advances
for
further
highlighted.
Finally,
application
prospects
challenges
future
clinical
translation
Advanced Materials,
Год журнала:
2023,
Номер
35(33)
Опубликована: Март 7, 2023
Abstract
Immunotherapy
has
made
remarkable
strides
in
cancer
therapy
over
the
past
decade.
However,
such
emerging
still
suffers
from
low
response
rates
and
immune‐related
adverse
events.
Various
strategies
have
been
developed
to
overcome
these
serious
challenges.
Therein,
sonodynamic
(SDT),
as
a
non‐invasive
treatment,
received
ever‐increasing
attention
especially
treatment
of
deep‐seated
tumors.
Significantly,
SDT
can
effectively
induce
immunogenic
cell
death
trigger
systemic
anti‐tumor
immune
response,
termed
immunotherapy.
The
rapid
development
nanotechnology
revolutionized
effects
with
robust
induction.
As
result,
more
innovative
nanosonosensitizers
synergistic
modalities
are
established
superior
efficacy
safe
profile.
In
this
review,
recent
advances
immunotherapy
summarized
particular
emphasis
on
how
be
explored
harness
for
amplifying
response.
Moreover,
current
challenges
field
prospects
its
clinical
translation
also
presented.
It
is
anticipated
that
review
provide
rational
guidance
facilitate
nanomaterials‐assisted
immunotherapy,
helping
pave
way
next‐generation
eventually
achieve
durable
patients.
Abstract
Programmed
cell
death
(PCD,
mainly
including
apoptosis,
necrosis,
ferroptosis,
pyroptosis,
and
autophagy)
immunogenic
(ICD),
as
important
mechanisms,
are
widely
reported
in
cancer
therapy,
understanding
the
relationship
between
two
is
significant
for
clinical
tumor
treatments.
Considering
that
vast
nanodrugs
developed
to
induce
PCD
ICD
simultaneously,
this
review,
interrelationship
described
using
nanomedicines
examples.
First,
an
overview
of
patterns
focus
on
morphological
differences
interconnections
among
them
provided.
Then
apoptosis
terms
endoplasmic
reticulum
stress
by
introducing
various
treatments
recent
developments
with
inducible
immunogenicity.
Next,
crosstalk
non‐apoptotic
(including
signaling
pathways
introduced
their
through
examples
further
illustrated.
Finally,
its
application
prospects
development
new
nanomaterials
summarized.
This
review
believed
deepen
ICD,
extend
biomedical
applications
nanodrugs,
promote
progress
therapy.
npj Precision Oncology,
Год журнала:
2024,
Номер
8(1)
Опубликована: Фев. 26, 2024
Abstract
Cancer
cell
growth,
metastasis,
and
drug
resistance
pose
significant
challenges
in
the
management
of
lung
adenocarcinoma
(LUAD).
However,
there
is
a
deficiency
optimal
predictive
models
capable
accurately
forecasting
patient
prognoses
guiding
selection
targeted
treatments.
Programmed
death
(PCD)
pathways
play
pivotal
role
development
progression
various
cancers,
offering
potential
as
prognostic
indicators
sensitivity
markers
for
LUAD
patients.
The
validation
were
conducted
by
integrating
13
PCD
patterns
with
comprehensive
analysis
bulk
RNA,
single-cell
RNA
transcriptomics,
pertinent
clinicopathological
details
derived
from
TCGA-LUAD
six
GEO
datasets.
Utilizing
machine
learning
algorithms,
we
identified
ten
critical
differentially
expressed
genes
associated
LUAD,
namely
CHEK2,
KRT18,
RRM2,
GAPDH,
MMP1,
CHRNA5,
TMPRSS4,
ITGB4,
CD79A,
CTLA4.
Subsequently,
programmed
index
(PCDI)
based
on
these
across
aforementioned
cohorts
integrated
this
relevant
clinical
features
to
develop
several
nomograms.
Furthermore,
observed
correlation
between
PCDI
immune
including
infiltration
expression
checkpoint
molecules.
Additionally,
found
that
patients
high
score
may
exhibit
immunotherapy
standard
adjuvant
chemotherapy
regimens;
however,
they
benefit
other
FDA-supported
drugs
such
docetaxel
dasatinib.
In
conclusion,
holds
signature
can
facilitate
personalized
treatment
RSC Advances,
Год журнала:
2022,
Номер
12(35), С. 22722 - 22747
Опубликована: Янв. 1, 2022
Sonodynamic
therapy
(SDT)
is
a
novel
non-invasive
treatment
for
cancer
combining
low-intensity
ultrasound
and
sonosensitizers.
SDT
activates
sonosensitizers
through
ultrasound,
releasing
energy
generating
reactive
oxygen
species
to
kill
tumor
cells.
Compared
with
traditional
photodynamic
(PDT),
promising
anti-cancer
the
advantages
of
better
targeting,
deeper
tissue
penetration,
higher
focusing
ability.
With
development
broad
application
nanomaterials,
tumor-targeting
specificity
can
deliver
deep
tumors
enhance
microenvironment.
In
this
review,
we
first
review
mechanisms
sonodynamic
therapy.
addition,
also
focus
on
current
types
latest
design
strategies
nanomaterials
in
Finally,
summarize
combined
strategy
Chemical Biology & Drug Design,
Год журнала:
2023,
Номер
102(2), С. 235 - 254
Опубликована: Апрель 7, 2023
Abstract
Bioisosterism
is
one
of
the
leading
strategies
in
medicinal
chemistry
for
design
and
modification
drugs,
consisting
replacing
an
atom
or
a
substituent
with
different
group
similar
chemical
properties
inherent
biocompatibility.
The
objective
such
exercise
to
produce
diversity
molecules
behavior
while
enhancing
desire
biological
pharmacological
properties,
without
inducing
significant
changes
framework.
In
drug
discovery
development,
optimization
absorption,
distribution,
metabolism,
elimination,
toxicity
(ADMETox)
profile
paramount
importance.
Silicon
appears
be
right
choice
as
carbon
isostere
because
they
possess
very
intrinsic
properties.
However,
replacement
by
silicon
pharmaceuticals
has
proven
result
improved
efficacy
selectivity,
physicochemical
bioavailability.
current
review
discusses
how
been
strategically
introduced
modulate
drug‐like
anticancer
agents,
from
molecular
strategy,
activity,
computational
modeling,
structure–activity
relationships
perspectives.
