Ultrasound-induced immune responses in tumors: A systematic review and meta-analysis DOI Creative Commons
Anne Rix, Helen Heinrichs, Céline Porte

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 146 - 157

Published: May 29, 2024

Ultrasound is widely used in the diagnosis and therapy of cancer. Tumors can be treated by thermal or mechanical tissue ablation. Furthermore, tumors manipulated hyperthermia, sonodynamic sonoporation, e.g., increasing tumor perfusion permeability biological barriers to enhance drug delivery. These treatments induce various immune responses tumors. However, conflicting data high heterogeneity between experimental settings make it difficult generalize effects ultrasound on immunity. Therefore, we performed a systematic review answer question: "Does alter reaction peripheral solid humans animals compared control conditions without ultrasound?" A literature search was PubMed, EMBASE, Web Science 24,401 potentially relevant publications were identified. Of these, 96 eligible for inclusion review. Experiments humans, rats, mice focused different types, primarily breast melanoma. We collected non-thermal settings, use sono-sensitizers sono-enhancers, anti-tumor therapies. Six meta-analyses quantify effect infiltration T cells (cytotoxic, helper, regulatory cells) blood cytokines (interleukin-6, interferon-γ, necrosis factor-α). provide robust scientific evidence that alters cell into increases cytokine concentrations. identified significant differences based type, mouse age. Stronger observed using hyperthermia combination with young mice. The latter may impair translational impact study results as most cancer patients are older. Thus, our help refining parameters therapeutic minimize diagnostic applications.

Language: Английский

Emerging Sonodynamic Therapy‐Based Nanomedicines for Cancer Immunotherapy DOI Creative Commons

Yunrong Yang,

Jia Huang, Min Liu

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 27, 2022

Cancer immunotherapy effect can be greatly enhanced by other methods to induce immunogenic cell death (ICD), which has profoundly affected as a highly efficient paradigm. However, these treatments have significant limitations, either causing damage of the immune system or limited superficial tumors. Sonodynamic therapy (SDT) ICD promote without affecting because its excellent spatiotemporal selectivity and low side effects. Nevertheless, SDT is still reactive oxygen species yield complex tumor microenvironment. Recently, some emerging SDT-based nanomedicines made numerous attractive encouraging achievements in field cancer due high immunotherapeutic efficiency. this cross-cutting research far from being widely explored huge professional barriers. Herein, characteristics microenvironment mechanisms are firstly systematically summarized. Subsequently, therapeutic mechanism fully summarized, advantages limitations discussed. The representative advances for further highlighted. Finally, application prospects challenges future clinical translation

Language: Английский

Citations

147
Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy DOI
Shuang Liang, Jianjun Yao, Dan Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: March 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Language: Английский

Citations

142
Interrelation between Programmed Cell Death and Immunogenic Cell Death: Take Antitumor Nanodrug as an Example DOI
Qi Meng, Binbin Ding,

Ping’an Ma

et al.

Small Methods, Journal Year: 2023, Volume and Issue: 7(5)

Published: Jan. 27, 2023

Abstract Programmed cell death (PCD, mainly including apoptosis, necrosis, ferroptosis, pyroptosis, and autophagy) immunogenic (ICD), as important mechanisms, are widely reported in cancer therapy, understanding the relationship between two is significant for clinical tumor treatments. Considering that vast nanodrugs developed to induce PCD ICD simultaneously, this review, interrelationship described using nanomedicines examples. First, an overview of patterns focus on morphological differences interconnections among them provided. Then apoptosis terms endoplasmic reticulum stress by introducing various treatments recent developments with inducible immunogenicity. Next, crosstalk non‐apoptotic (including signaling pathways introduced their through examples further illustrated. Finally, its application prospects development new nanomaterials summarized. This review believed deepen ICD, extend biomedical applications nanodrugs, promote progress therapy.

Language: Английский

Citations

51
Machine learning reveals diverse cell death patterns in lung adenocarcinoma prognosis and therapy DOI Creative Commons
Shun Wang,

Ruohuang Wang,

Dingtao Hu

et al.

npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)

Published: Feb. 26, 2024

Abstract Cancer cell growth, metastasis, and drug resistance pose significant challenges in the management of lung adenocarcinoma (LUAD). However, there is a deficiency optimal predictive models capable accurately forecasting patient prognoses guiding selection targeted treatments. Programmed death (PCD) pathways play pivotal role development progression various cancers, offering potential as prognostic indicators sensitivity markers for LUAD patients. The validation were conducted by integrating 13 PCD patterns with comprehensive analysis bulk RNA, single-cell RNA transcriptomics, pertinent clinicopathological details derived from TCGA-LUAD six GEO datasets. Utilizing machine learning algorithms, we identified ten critical differentially expressed genes associated LUAD, namely CHEK2, KRT18, RRM2, GAPDH, MMP1, CHRNA5, TMPRSS4, ITGB4, CD79A, CTLA4. Subsequently, programmed index (PCDI) based on these across aforementioned cohorts integrated this relevant clinical features to develop several nomograms. Furthermore, observed correlation between PCDI immune including infiltration expression checkpoint molecules. Additionally, found that patients high score may exhibit immunotherapy standard adjuvant chemotherapy regimens; however, they benefit other FDA-supported drugs such docetaxel dasatinib. In conclusion, holds signature can facilitate personalized treatment

Language: Английский

Citations

42
Application of nanosonosensitizer materials in cancer sono-dynamic therapy DOI Creative Commons
Chaotao Hu,

Biao Hou,

Songlin Xie

et al.

RSC Advances, Journal Year: 2022, Volume and Issue: 12(35), P. 22722 - 22747

Published: Jan. 1, 2022

Sonodynamic therapy (SDT) is a novel non-invasive treatment for cancer combining low-intensity ultrasound and sonosensitizers. SDT activates sonosensitizers through ultrasound, releasing energy generating reactive oxygen species to kill tumor cells. Compared with traditional photodynamic (PDT), promising anti-cancer the advantages of better targeting, deeper tissue penetration, higher focusing ability. With development broad application nanomaterials, tumor-targeting specificity can deliver deep tumors enhance microenvironment. In this review, we first review mechanisms sonodynamic therapy. addition, also focus on current types latest design strategies nanomaterials in Finally, summarize combined strategy

Language: Английский

Citations

46
Current advances in metal–organic frameworks for cancer nanodynamic therapies DOI

Zhu Liu,

Ziwei Yan,

Yifan Di

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215434 - 215434

Published: Sept. 17, 2023

Language: Английский

Citations

44
Mitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy DOI

Thuy Giang Nguyen Cao,

Quan Truong Hoang, Eun Ji Hong

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 651 - 663

Published: Jan. 25, 2023

Language: Английский

Citations

37
Recent advances in sonodynamic therapy by MOFs-based platforms for biomedical applications DOI
Wenbin Hu, Sanying Wang,

Chenyi Jiang

et al.

Dyes and Pigments, Journal Year: 2023, Volume and Issue: 219, P. 111596 - 111596

Published: Aug. 1, 2023

Language: Английский

Citations

33
Silicon switch: Carbon–silicon Bioisosteric replacement as a strategy to modulate the selectivity, physicochemical, and drug‐like properties in anticancer pharmacophores DOI
Jean Fotie,

Caitlyn M. Matherne,

Jordan E. Wroblewski

et al.

Chemical Biology & Drug Design, Journal Year: 2023, Volume and Issue: 102(2), P. 235 - 254

Published: April 7, 2023

Abstract Bioisosterism is one of the leading strategies in medicinal chemistry for design and modification drugs, consisting replacing an atom or a substituent with different group similar chemical properties inherent biocompatibility. The objective such exercise to produce diversity molecules behavior while enhancing desire biological pharmacological properties, without inducing significant changes framework. In drug discovery development, optimization absorption, distribution, metabolism, elimination, toxicity (ADMETox) profile paramount importance. Silicon appears be right choice as carbon isostere because they possess very intrinsic properties. However, replacement by silicon pharmaceuticals has proven result improved efficacy selectivity, physicochemical bioavailability. current review discusses how been strategically introduced modulate drug‐like anticancer agents, from molecular strategy, activity, computational modeling, structure–activity relationships perspectives.

Language: Английский

Citations

32
Multifunctional nano MOF drug delivery platform in combination therapy DOI

Dongwei Ma,

Gang Wang, Jing-Sheng Lu

et al.

European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 261, P. 115884 - 115884

Published: Oct. 16, 2023

Language: Английский

Citations

31