International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138428 - 138428
Published: Dec. 1, 2024
Language: Английский
ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 884 - 890
Published: Feb. 7, 2025
Language: Английский
Citations
2
Surfaces and Interfaces, Journal Year: 2024, Volume and Issue: 51, P. 104676 - 104676
Published: Aug. 1, 2024
Language: Английский
Citations
4
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
Abstract Meibomian gland dysfunction (MGD) is a leading cause of evaporative dry eye disease, presenting challenge for targeted treatment. Traditional topical ocular drug delivery methods often fail to effectively reach the meibomian glands (MGs). To address this, study has developed soluble microneedles (MN) patch comprising poly(vinyl alcohol), cyclodextrin modified polyacrylic acid, and new indocyanine green. This innovative MN facilitates transdermal release peroxisome proliferator‐activated receptor gamma (PPAR‐γ) agonists, such as rosiglitazone in response near‐infrared ray induced temperature changes. By safely optimizing temperature, liquefied meibum lips, thereby alleviating duct obstruction while releasing drug. patches exhibit sufficient mechanical strength effective skin penetration, its biosafety eyelid application been rigorously assessed vitro vivo. The therapeutic efficiency loaded (ROSI‐MN) treatment MGD evaluated high‐fat mice. After three months treatments, ROSI‐MN administration significantly alleviated clinical manifestations, including surface damage, lipid deposits, glandular hypertrophy, inflammatory infiltration, ultimately improving microstructure biofunction MGs. In conclusion, hold promise an strategy treating diseases beyond MGD.
Language: Английский
Citations
0
Expert Opinion on Drug Safety, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9
Published: Feb. 8, 2025
Background Approved by the FDA in 2021, varenicline solution is first nasal spray specifically designed to enhance basal tear film production for treating dry eye disease (DED). However, there a lack of data comprehensively comparing its safety profile conventional DED therapies. Herein, we assess whether ocular adverse events (AEs) are disproportionately reported with real-world use solution.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125355 - 125355
Published: Feb. 1, 2025
Language: Английский
Citations
0
Journal of Medical Microbiology, Journal Year: 2025, Volume and Issue: 74(3)
Published: March 12, 2025
Introduction. Eye diseases are widespread all over the world and, if left untreated, can lead to blindness. Hypothesis. The use of 0.05% cyclosporine A (CsA) solution for treatment dry eye causes a decrease in discomfort and pain improves objective measures such as tear film breakdown time, Schirmer test results Oxford scale scores due its anti-inflammatory immunomodulatory properties that contribute improved stability production. Aim. This study aimed investigate impact CsA on progression ocular surface diseases. Methodology. An experiment was conducted basis FOCUS ophthalmology centre, Kazakhstan. group 100 individuals diagnosed with mild severe illness were administered drops part protocol. Results. positive effect is explained by effects CsA. showed disease led pain, well an improvement measures, including scores. visual analogue significant reduction symptoms, from 6.8 points at baseline 3.7 day 60. In total, 20% patients reported moderate side effects, during instillation redness surface. Conclusion. It concluded these reduced patient condition enhanced indicators scale, breakup corneal conjunctival staining. differs previous ones it focuses efficacy also examines spectrum frequency which not sufficiently covered studies.
Language: Английский
Citations
0
Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101276 - 101276
Published: March 1, 2025
Language: Английский
Citations
0
Langmuir, Journal Year: 2025, Volume and Issue: unknown
Published: April 4, 2025
Ocular lubrication is a critical component of the biological system. Factors such as tear film instability and corneal epithelial damage can lead to increased friction on ocular surface during blinking, which negatively impacts quality life results in economic burden. Eye drops are commonly used therapeutic purposes. Due frequent movement (blinking, secretion, nasolacrimal drainage), their bioavailability low, requiring applications. In this study, methacylated gellan gum (GGMA) hydrogels were synthesized using methacrylic anhydride low-acyl raw materials. The elastic modulus GGMA hydrogel nearly threefold after introduction alkali metal ions. Macroscopic superlubricity was achieved experiments simulating environment. At contact pressure close 10 kPa, COF reduced 0.004. Detailed sophisticated simulations revealed underlying mechanism, showing that attributed hydration properties ions adsorbed onto surface. exhibits excellent lubricating properties, offering promising potential for enhancing supporting eye health.
Language: Английский
Citations
0
Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Abstract As one of the 3D printing technologies, digital light processing (DLP) technology has been widely applied in biomedical engineering. The principles and advantages DLP are compared with other while characteristics applicable fields each technique analyzed. applications tissue engineering, medical devices pharmaceutical field classified summarized. Besides, prospects challenges engineering discussed. With continuous advancement, will play an increasingly important role personalized medicine regenerative medicine.
Language: Английский
Citations
0
Bioactive Materials, Journal Year: 2025, Volume and Issue: 50, P. 396 - 413
Published: April 22, 2025
Language: Английский
Citations
0