Cause and consequence of heterogeneity in human mesenchymal stem cells: Challenges in clinical application

Pathology - Research and Practice, Год журнала: 2024, Номер 260, С. 155354 - 155354

Опубликована: Май 15, 2024

Язык: Английский

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The Dual Role of Mesenchymal Stem Cells in Cancer Pathophysiology: Pro-Tumorigenic Effects versus Therapeutic Potential

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(17), С. 13511 - 13511

Опубликована: Авг. 31, 2023

Mesenchymal stem/stromal cells (MSCs) are multipotent involved in numerous physiological events, including organogenesis, the maintenance of tissue homeostasis, regeneration, or repair. MSCs increasingly recognized as playing a major, dual, and complex role cancer pathophysiology through their ability to limit promote tumor progression. Indeed, these known interact with microenvironment, modulate behavior cells, influence functions, distant metastasis formation secretion mediators, regulation cell–cell interactions, modulation immune response. This dynamic network can lead establishment immunoprivileged niches new tumors proliferation/differentiation into cancer-associated fibroblasts well stem cells. However, exhibit also therapeutic effects anti-tumor, anti-proliferative, anti-inflammatory, anti-oxidative effects. The interest is currently growing, mainly due selectively migrate penetrate sites, which would make them relevant vectors for advanced therapies. Therefore, this review aims provide an overview double-edged sword implications processes. potential will be reviewed melanoma lung cancers.

Язык: Английский

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Nanotechnology and bioengineering approaches to improve the potency of mesenchymal stem cell as an off‐the‐shelf versatile tumor delivery vehicle

Medicinal Research Reviews, Год журнала: 2024, Номер 44(4), С. 1596 - 1661

Опубликована: Фев. 1, 2024

Abstract Targeting actionable mutations in oncogene‐driven cancers and the evolution of immuno‐oncology are two prominent revolutions that have influenced cancer treatment paradigms caused emergence precision oncology. However, intertumoral intratumoral heterogeneity main challenges both fields treatment. In other words, finding a universal marker or pathway patients suffering from particular type is challenging. Therefore, targeting single hallmark with targeted therapeutic will not be efficient for fighting against tumor heterogeneity. Mesenchymal stem cells (MSCs) possess favorable characteristics cellular therapy, including their hypoimmune nature, inherent tumor‐tropism property, straightforward isolation, multilineage differentiation potential. MSCs can loaded various chemotherapeutics oncolytic viruses. The combination these intrinsic features possibility genetic manipulation makes them versatile delivery vehicle used vivo selective chemotherapeutic biological therapeutics. as biofactory local production chemical anticancer agents at site. MSC‐mediated immunotherapy could facilitate sustained release immunotherapeutic specifically site, allow achievement concentrations without need repetitive systemic administration high doses. Despite enthusiasm evoked by preclinical studies MSC therapy approaches, translation into clinical applications has faced serious challenges. This manuscript, critical viewpoint, reviewed evaluated tool gene immunotherapy, chemotherapy. Then, novel nanotechnology bioengineering approaches improve potency overcoming related to low localization sites discussed.

Язык: Английский

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Role of Fruit-Derived Antioxidants in Fighting Cancer: A Narrative Review

Indian Journal of Clinical Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

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Development and application of oncolytic viruses as the nemesis of tumor cells

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Июнь 12, 2023

Viruses and tumors are two pathologies that negatively impact human health, but what occurs when a virus encounters tumor? A global consensus among cancer patients suggests surgical resection, chemotherapy, radiotherapy, other methods the primary means to combat cancer. However, with innovation development of biomedical technology, tumor biotherapy (immunotherapy, molecular targeted therapy, gene oncolytic etc.) has emerged as an alternative treatment for malignant tumors. Oncolytic viruses possess numerous anti-tumor properties, such directly lysing cells, activating immune responses, improving microenvironment. Compared traditional immunotherapy, therapy offers advantages including high killing efficiency, precise targeting, minimal side effects. Although (OV) was introduced novel approach in 19th century, its efficacy suboptimal, limiting widespread application. since U.S. Food Drug Administration (FDA) approved first OV drug, T-VEC, 2015, interest grown significantly. In recent years, shown increasingly promising application prospects become major research focus field treatment. This article reviews development, classification, progress viruses, well their mechanisms action, therapeutic methods, routes administration.

Язык: Английский

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Mesenchymal stem cells - the secret agents of cancer immunotherapy: Promises, challenges, and surprising twists

Oncotarget, Год журнала: 2024, Номер 15(1), С. 793 - 805

Опубликована: Ноя. 22, 2024

// Theia Minev 1 , Shani Balbuena Jaya Mini Gill Francesco M. Marincola 2 Santosh Kesari 3 and Feng Lin CureScience Institute, San Diego, CA 92121, USA Sonata Therapeutics, Boston, MA 02472, Department of Translational Neurosciences, Pacific Neuroscience Institute Providence Saint John's Health Center, Cancer Santa Monica, 90404, Correspondence to: Lin, email: [email protected] Keywords: mesenchymal stem cells; genetic engineering; cancer immunotherapy; cell homing; delivery Received: August 20, 2024 Accepted: November 05, Published: 22, Copyright: © et al. This is an open access article distributed under the terms Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, reproduction in any medium, provided original author source are credited. ABSTRACT Mesenchymal cells (MSCs) recognized for their immunomodulatory capabilities, tumor-homing abilities, capacity to serve as carriers therapeutic agents. review delves into role adoptively transferred MSCs tumor progression, interactions with microenvironment, use delivering anti-cancer drugs, oncolytic viruses, material. It also addresses challenges limitations associated MSC therapy, such variability preparations potential tumorigenic effects emphasizing need advanced engineering personalized approaches enhance efficacy. The concludes optimistic outlook on future MSC-based therapies, underscoring promise develop effective treatments.

Язык: Английский

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Recent advances in molecular targeted therapy of lung cancer: Possible application in translation medicine.

PubMed, Год журнала: 2024, Номер 27(2), С. 122 - 133

Опубликована: Янв. 1, 2024

Lung cancer is one of the leading causes death among all deaths. This classified into two different histological subtypes: non-small cell lung (NSCLC), which most common subtype, and small (SCLC), aggressive subtype. Understanding molecular characteristics has expanded our knowledge cellular origins pathways affected by each these subtypes contributed to development new therapies. Traditional treatments for include surgery, chemotherapy, radiotherapy. Advances in understanding nature specificity have led immunotherapy, newest specialized treatment cancer. Each advantages disadvantages side effects. Today, combination therapy reduces effects increases speed recovery. Despite significant progress that been made last decade, further research drugs therapies needed extend clinical benefits improve outcomes In this review article, we discussed their combinations from advanced newest.

Язык: Английский

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Synthesis of novel skipped diene-3-halocoumarin conjugates as potent anticancer and antibacterial biocompatible agents

Results in Chemistry, Год журнала: 2024, Номер 11, С. 101846 - 101846

Опубликована: Окт. 1, 2024

Язык: Английский

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Advances in Gene Therapy with Oncolytic Viruses and CAR-T Cells and Therapy-Related Groups

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(4), С. 268 - 268

Опубликована: Апрель 10, 2025

Cancer gene therapy is attracting considerable attention as a new treatment method for overcoming intractable cancers. CAR-T cell has already achieved remarkable results, particularly hematological tumors. Because cells can increase within the body, they have advantage of requiring only single administration. In addition, targeting CD19 antigen been established relapsed or refractory disease in young people with CD19-positive acute B-cell leukemia (B-acute lymphoblastic leukemia, B-ALL) and diffuse large lymphoma (DLBCL). addition to therapy, oncolytic viruses represent promising approach cancer treatment, some clinical use others being researched their potential benefits. These infect kill cells, triggering an immune response that helps body recognize fight cancer. Oncolytic virus form immunotherapy uses modified target destroy tumor while potentially stimulating antitumor responses. shown activity trials, approved specific cancers like melanoma. Research ongoing improve efficacy, expand other types, overcome logistical challenges associated delivery. Gene treat diseases caused by recessive disorders cystic fibrosis, hemophilia, muscular dystrophy, sickle anemia, well acquired genetic diseases, such viral infections immunodeficiency syndrome (AIDS).

Язык: Английский

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Applications of Modified Mesenchymal Stem Cells as Targeted Systems against Tumor Cells

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7791 - 7791

Опубликована: Июль 16, 2024

Combined gene and cell therapy are promising strategies for cancer treatment. Given the complexity of cancer, several approaches actively studied to fight this disease. Using mesenchymal stem cells (MSCs) has demonstrated dual antitumor protumor effects as they exert massive immune/regulatory on tissue microenvironment. MSCs have been widely investigated exploit their target delivery system. They can be genetically modified overexpress genes selectively or more efficiently eliminate tumor cells. Current tend produce effective safer therapies using derivatives; however, effect achieved by engineered in solid tumors is still limited depends factors such source, transgene, target. This review describes progress focused a cornerstone against tumors, addressing different MSC-engineering methods that approached over decades research. Furthermore, we summarize main objectives most common cancers discuss challenges, limitations, risks, advantages targeted treatments combined with conventional ones.

Язык: Английский

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