Biomedicines,
Год журнала:
2025,
Номер
13(6), С. 1308 - 1308
Опубликована: Май 27, 2025
Background:
Diabetic
macular
edema
(DME)
is
the
leading
cause
of
vision
impairment
in
diabetic
patients,
with
intravitreal
anti-vascular
endothelial
growth
factor
(anti-VEGF)
injections
being
first-line
therapy.
However,
one-third
patients
exhibit
persistent
DME
despite
treatment,
suggesting
additional
pathogenic
factors.
This
study
aimed
to
evaluate
predictive
value
complete
blood
count
(CBC)-based
inflammation
indexes
and
optical
coherence
tomography
(OCT)
parameters
determining
early
anti-VEGF
treatment
effectiveness
DME.
Methods:
One
hundred
four
naïve
DME,
treated
0.05
mL
aflibercept
were
retrospectively
analyzed.
Blood
analyzed
included
neutrophil-to-lymphocyte
ratio
(NLR),
monocyte-to-lymphocyte
(MLR),
platelet-to-lymphocyte
(PLR),
systemic
immune-inflammation
index
(SII).
Baseline
OCT
biomarkers
subretinal
fluid
(SRF),
intraretinal
cysts
(IRC),
hyperreflective
retinal
spots
(HRS),
disorganization
inner
layers
(DRIL).
Treatment
response
was
defined
as
a
minimum
10%
reduction
central
thickness
(CMT)
at
one
month
post-injection.
Results:
NLR,
MLR,
PLR,
SII
significantly
higher
non-responders
(p
<
0.001),
but
their
fair,
an
area
under
ROC
curve
ranging
between
0.704
(MLR)
0.788
A
multivariate
model
including
SII,
initial
CMT,
presence
IRC
showed
excellent
prediction
for
anatomical
(AUC
0.911).
At
same
time,
lower
DRIL,
SRF,
absence
HRF
correlated
gain
BCVA.
Conclusions:
CBC-derived
indices
have
prognostic
predicting
therapy
terms
functional
outcomes.
These
findings
could
help
identify
poor
responders
guide
personalized
strategies.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Март 6, 2024
Affected
by
aging,
the
elderly
diabetes
patients
have
many
pathological
characteristics
different
from
young
people,
including
more
complications,
vascular
cognitive
impairment,
osteoporosis,
and
sarcopenia.
This
article
will
explore
their
pathogenesis
mechanism
of
Traditional
Chinese
medicine
(TCM)
intervention,
use
method
systematic
review
to
evaluate
clinical
application
TCM
in
diabetes.
Non-alcoholic
fatty
liver
disease
stands
as
the
predominant
cause
of
chronic
disease,
with
its
prevalence
and
morbidity
expected
to
escalate
significantly,
leading
substantial
healthcare
costs
diminished
health-related
quality
life.
It
comprises
a
range
manifestations
that
commence
basic
steatosis,
involving
accumulation
lipids
in
hepatocytes,
distinctive
histological
feature.
If
left
untreated,
it
often
advances
non-alcoholic
steatohepatitis,
marked
by
inflammatory
and/or
fibrotic
hepatic
changes,
eventual
development
disease-related
cirrhosis
hepatocellular
carcinoma.
Because
liver's
vital
role
body
metabolism,
is
considered
both
consequence
contributor
metabolic
abnormalities
observed
syndrome.
As
date,
there
are
no
authorized
pharmacological
agents
for
or
steatohepatitis.
Semaglutide,
glycemic
weight
loss
advantages,
could
potentially
offer
benefits
individuals
disease.
This
review
aims
investigate
impact
semaglutide
on
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 6, 2025
Vascular
calcification
(VC)
commonly
occurs
in
diabetes
and
is
associated
with
cardiovascular
disease
incidence
mortality.
Currently,
there
no
drug
treatment
for
VC.
The
Danlian-Tongmai
formula
(DLTM)
a
traditional
Chinese
medicine
(TCM)
prescription
used
diabetic
VC
(DVC),
but
its
mechanisms
of
action
remain
unclear.
This
study
aims
to
elucidate
the
effects
DLTM
on
DVC
explore
underlying
action.
Ultra-high-performance
liquid
chromatography-mass
spectrometry
(UHPLC-MS)
was
identify
metabolites
DLTM.
A
rat
model
established
using
streptozotocin
(STZ)
combined
vitamin
D3
(VitD3).
were
evaluated
through
alizarin
red
staining,
calcium
deposition,
changes
osteogenic
contractile
markers.
specific
molecular
mechanism
treating
comprehensively
analyzed
by
transcriptomics,
docking
vivo
experimental
verification.
We
identified
108
major
In
vivo,
high-dose
significantly
alleviated
rats.
Transcriptomic
analysis
showed
that
markedly
altered
transcriptomic
profile
aortas,
which
regulating
CCN3/NOTCH
signaling
pathway,
promoting
vascular
smooth
muscle
contraction,
inhibiting
inflammatory
responses.
Molecular
dynamics
simulation
demonstrated
strong
binding
interactions
between
key
molecules
within
including
NOTCH1,
DLL1,
DLL4,
hes1,
hey1.
experiments
confirmed
could
upregulate
CCN3,
inhibit
activation
NOTCH
ligands
DLL1
downstream
transcription
factors
hes1
hey1,
reduce
release
cytokines
IL6,
IL1β,
TNFα.
alleviates
axis
Our
research
provides
basis
clinical
transformation
