The Role of Endothelial Cell Mitophagy in Age-Related Cardiovascular Diseases DOI Creative Commons

Quancheng Han,

Yiding Yu,

Xiujuan Liu

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Aging is a major risk factor for cardiovascular diseases (CVD), and mitochondrial autophagy impairment considered significant physiological change associated with aging. Endothelial cells play crucial role in maintaining vascular homeostasis function, participating various processes such as regulating tone, coagulation, angiogenesis, inflammatory responses. As aging progresses, endothelial worsens, leading to the development of numerous diseases. Therefore, vital preventing treating age-related However, there currently lack systematic reviews this area. To address gap, we have written review provide new research therapeutic strategies managing

Language: Английский

Mechanism of traditional Chinese medicine in elderly diabetes mellitus and a systematic review of its clinical application DOI Creative Commons
Qiqi Zhang,

Shiwan Hu,

Zishan Jin

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 6, 2024

Affected by aging, the elderly diabetes patients have many pathological characteristics different from young people, including more complications, vascular cognitive impairment, osteoporosis, and sarcopenia. This article will explore their pathogenesis mechanism of Traditional Chinese medicine (TCM) intervention, use method systematic review to evaluate clinical application TCM in diabetes.

Language: Английский

Citations

4
Progress in the Study of Triglyceride Glucose Index and Vascular Complications in Type 2 Diabetes DOI

月 赵

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 1232 - 1236

Published: Jan. 1, 2025

Language: Английский

Citations

0
Novel indicator of microvascular complications in patients with type 2 diabetes mellitus and shortened erythrocyte lifespan: a multicenter cross-sectional analysis DOI Creative Commons

Yunqi Wu,

Binshan Zhang,

Xin Ma

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 22, 2025

Language: Английский

Citations

0
SETD7 drives diabetic endothelial dysfunction through FBXO45-mediated GPX4 ubiquitylation DOI Creative Commons
Wen Zhong,

Ruoxue Chen,

Jialin Zhao

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 24, 2025

Vasculopathy is the most prevalent complication of diabetes. Endothelial damage, a primary contributor to hyperglycemic vascular complications, impacts macro- and micro-vasculatures, causing functional impairment multiple organs. SETD7 was initially identified as transcriptional activator based on its ability methylate histone 3 lysine 4. However, function in context diabetic endothelial dysfunction remains poorly understood. This study aims elucidate involvement underlying mechanisms dysfunction. knockout mice were generated investigate effects Streptozotocin (STZ)-induced hyperglycemia injury. Endothelial-specific interruption adeno-associated virus (AAV) system utilized injury BKS-DB(Lepr) KO/KO (db/db) mice. In vitro manipulation activation or knockdown conducted assess regulation lipid peroxidation, oxidative stress, cell rat aortic cells (RAECs) under high glucose conditions. Our revealed that deficiency partially restored damaged attenuated inflammatory response caused by both STZ-induced db/db Moreover, aggravated stress resulted profound through Glutathione Peroxidase 4 (GPX4)-mediated peroxidation RAECs. Mechanistically, reduced p53 mono-methylation blocked FBXO45 transcription, thereby inhibiting protein degradation GPX4 subsequent well stress. summary, our demonstrates SETD7-p53-FBXO45-GPX4 involved glucose-induced exacerbated dysfunction, which offering great significance for mitigating hyperglycemia-induced damage.

Language: Английский

Citations

0
Danlian-Tongmai formula improves diabetic vascular calcification by regulating CCN3/NOTCH signal axis to inhibit inflammatory reaction DOI Creative Commons
Wenting Wang, Yiwen Li, Mengmeng Zhu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Vascular calcification (VC) commonly occurs in diabetes and is associated with cardiovascular disease incidence mortality. Currently, there no drug treatment for VC. The Danlian-Tongmai formula (DLTM) a traditional Chinese medicine (TCM) prescription used diabetic VC (DVC), but its mechanisms of action remain unclear. This study aims to elucidate the effects DLTM on DVC explore underlying action. Ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) was identify metabolites DLTM. A rat model established using streptozotocin (STZ) combined vitamin D3 (VitD3). were evaluated through alizarin red staining, calcium deposition, changes osteogenic contractile markers. specific molecular mechanism treating comprehensively analyzed by transcriptomics, docking vivo experimental verification. We identified 108 major In vivo, high-dose significantly alleviated rats. Transcriptomic analysis showed that markedly altered transcriptomic profile aortas, which regulating CCN3/NOTCH signaling pathway, promoting vascular smooth muscle contraction, inhibiting inflammatory responses. Molecular dynamics simulation demonstrated strong binding interactions between key molecules within including NOTCH1, DLL1, DLL4, hes1, hey1. experiments confirmed could upregulate CCN3, inhibit activation NOTCH ligands DLL1 downstream transcription factors hes1 hey1, reduce release cytokines IL6, IL1β, TNFα. alleviates axis Our research provides basis clinical transformation

Language: Английский

Citations

0
Exploring Endothelial Cell Dysfunction’s Impact on the Brain-Retina Microenvironment Connection: Molecular Mechanisms and Implications DOI
Wahid Shah, Yuanyuan Gong, Xinhan Qiao

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

Citations

0
Unveiling the Negative Synergistic Effect of Wall Shear Stress and Insulin on Endothelial NO Dynamics by Mathematical Modeling DOI

Yuyuan Zhang,

Yongjiang Li, Xu-Qu Hu

et al.

Bulletin of Mathematical Biology, Journal Year: 2025, Volume and Issue: 87(4)

Published: Feb. 19, 2025

Language: Английский

Citations

0
Crosstalk between microRNA and inflammation; critical regulator of diabetes DOI

Amr Ali Mohamed Abdelgawwad El-Sehrawy,

Mohammed H. Mohammed,

Omar Dheyauldeen Salahdin

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: 447(1), P. 114507 - 114507

Published: March 7, 2025

Language: Английский

Citations

0
Impdh1 was identified as a key protein promotes diabetic vasculopathy by intervention of vascular endothelial cell pyroptosis DOI Creative Commons

Ruiqiang Xie,

Hong Gao, Hongyan Xie

et al.

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 13, 2025

Diabetic angiopathy (DA) is a diabetic vascular complication. Pyroptosis an inflammatory death that plays important role in the development of DA, but underlying mechanisms have not been fully elucidated. The GSE169332 dataset from Gene Expression Omnibus (GEO) was subjected to single-cell RNA sequencing (scRNA-seq) analysis, and data mice were bulk RNA-seq. pathway through which microenvironment participated DA explored by pseudotime analysis cell-cell communication. models constructed using vitro mouse models. histopathological changes collected aorta observed hematoxylin eosin (H&E) Masson staining. distribution expression phenotypic markers related pyroptosis aortic tissues (NLRP3, pro-Caspase1, GSDMD-N) immunohistochemistry (IHC) or immunofluorescence (IF) Following silencing high glucose (HG)-induced Impdh1 endothelial cells (ECs), detected real-time quantitative reverse transcription PCR (qRT-PCR), Impdh1, NLRP3, GSDMD IF staining; cell migration scratch assay, viability counting kit-8 (CCK-8) tube formation assay; levels IL-1β IL-18 enzyme-linked immunosorbent assay (ELISA) kits. identified scRNA-seq RNA-seq as key molecule progression associated with ECs. By constructing it found can inhibit pyroptosis. Silencing HG-induced revealed effective amelioration EC damage potential pyroptosis-related gene GEO protects ECs inhibiting inflammation. Not applicable.

Language: Английский

Citations

0
Use of adjunctive glycaemic agents with vascular protective properties in individuals with type 1 diabetes: Potential benefits and risks DOI
Ahmad Mamoun Rajab, Sam M. Pearson, Ramzi Ajjan

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Glycaemic therapy in type 1 diabetes (T1D) is focused on insulin, with the majority of studies investigating different insulin preparations, delivery devices and dosing accuracy methods. While deficiency key mechanism for hyperglycaemia T1D, individuals this condition can also develop resistance (IR), making optimisation glycaemia more challenging. Importantly, IR T1D increases risk both microvascular macrovascular complications; yet, it rarely targeted routine clinical care. In narrative review, we briefly discuss mechanistic pathways complications emphasising adverse role IR. We subsequently cover use adjunctive glycaemic therapies improving metabolic profile focusing that have possible or definite cardiovascular renal protective properties 2 diabetes. These include metformin agents thiazolidinedione, Sodium-Glucose Cotransporter-2 inhibitor (SGLT2i) Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RA) groups. addition to reviewing these parameters, address their potential vascular effects T1D. suggest a pragmatic approach using based current knowledge benefits risks, while highlighting gaps areas require further research. It hoped review raises awareness offers healthcare professionals simple guidance such management high-risk

Language: Английский

Citations

0