Cell Death and Disease,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 18, 2025
Abstract
Cardiovascular
diseases
are
the
leading
causes
of
death
worldwide.
However,
there
still
shortcomings
in
currently
employed
treatment
methods
for
these
diseases.
Therefore,
exploring
molecular
mechanisms
underlying
cardiovascular
is
an
important
avenue
developing
new
strategies.
Previous
studies
have
confirmed
that
metabolic
and
epigenetic
alterations
often
involved
across
patients.
Moreover,
factors
interact
with
each
other
affect
progression
a
coordinated
manner.
Lactylation
novel
posttranslational
modification
(PTM)
links
metabolism
epigenetics
affects
disease
progression.
analyzing
crosstalk
between
cellular
expected
to
provide
insights
development
The
purpose
this
review
describe
relationship
heart
such
as
failure,
myocardial
infarction,
atherosclerosis,
focus
on
acylation
methylation,
propose
potential
therapeutic
measures.
Pharmacological Research,
Год журнала:
2025,
Номер
212, С. 107588 - 107588
Опубликована: Янв. 7, 2025
Atherosclerosis,
a
multifactorial
progressive
inflammatory
disease,
is
the
common
pathology
underlying
cardiovascular
and
cerebrovascular
diseases.
The
macrophage
plasticity
involved
in
pathogenesis
of
atherosclerosis.
With
advance
metabolomics
epigenetics,
metabolites/metabolic
epigenetic
modification
such
as
DNA
methylation,
histone
noncoding
RNA,
play
crucial
role
polarization
progression
Herein,
we
provide
comprehensive
review
essential
metabolic
regulation,
well
crosstalk
between
two
regulating
We
also
highlight
potential
therapeutic
strategies
via
modifications
for
atherosclerosis,
offer
recommendations
to
our
knowledge
roles
metabolic-epigenetic
context
Fundamental
studies
that
elucidate
mechanisms
by
which
regulation
influence
atherosclerosis
will
pave
way
novel
approaches.
Heliyon,
Год журнала:
2024,
Номер
10(6), С. e28158 - e28158
Опубликована: Март 1, 2024
Objective(s):
Considering
the
poor
prognosis
of
ischemic
heart
disease
and
diminished
effectiveness
cardioprotective
interventions
in
elderly,
it
becomes
necessary
to
investigate
interaction
aging
with
protection
during
myocardial
ischemia/reperfusion
injury
(IRI).
This
study
was
conducted
assess
impact
mitoquinone
(MitoQ)
alpha-lipoic
acid
(ALA)
preconditioning
on
cardioprotection
following
IRI
aged
rats.MethodsFifty
male
Wistar
rats
(22–24
months
old)
were
divided
into
five
groups
including
Sham,
IR,
treatment
receiving
ALA
and/or
MitoQ.
Treatment
received
100
mg/kg/day
by
oral
gavage
10
MitoQ
intraperitoneal
injection
for
14
consecutive
days.
An
vivo
model
established
through
ligation
coronary
artery
30
min
it's
reopening
24
h.
The
left
ventricles
removed
at
end
reperfusion
oxidative
stress
indicators,
mitochondrial
function,
expression
dynamic
genes.
Myocardial
infarct
size
(IS),
hemodynamic
parameters,
serum
lactate
dehydrogenase
(LDH)
level
also
measured.ResultsCombination
reduced
stress,
LDH
level,
IS
hearts
subjected
IRI.
It
enhanced
function
upregulated
Mfn1,
Mfn2,
Foxo1
downregulated
Drp1
Fis1
gene
expression.
Co-administration
partially
restored
IRI-induced
changes
normal
state.
In
all
measured
effect
combined
greater
than
monotherapies.ConclusionThe
combination
therapy
demonstrated
considerable
therapeutic
potential
protecting
against
improving
dynamics
rats.
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 10, 2025
Lactate,
long
viewed
as
a
byproduct
of
glycolysis
and
metabolic
waste.
Initially
identified
within
the
context
yogurt
fermentation,
lactate's
role
extends
beyond
culinary
applications
to
its
significance
in
biochemical
processes.
Contemporary
research
reveals
that
lactate
functions
not
merely
terminal
product
but
also
nexus
for
initiating
physiological
pathological
responses
body.
Lysine
lactylation
(Kla),
novel
post-translational
modification
(PTM)
proteins,
has
emerged
pivotal
mechanism
by
which
exerts
regulatory
influence.
This
epigenetic
potential
alter
gene
expression
patterns,
thereby
impacting
Increasing
evidence
indicates
correlation
between
adverse
prognosis
various
malignancies.
Consequently,
this
review
article
aims
encapsulate
proteins
interact
with
lactate,
elucidate
tumorigenesis
progression,
explore
therapeutic
targets
afforded
modulation
lactylation.
The
objective
is
clarify
oncogenic
provide
strategic
framework
future
directions
burgeoning
field.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 24, 2025
Lactylation,
a
newly
discovered
protein
posttranslational
modification
(PTM)
in
2019,
primarily
occurs
on
lysine
residues.
Lactylation
of
histones
was
initially
identified,
and
subsequent
studies
have
increasingly
demonstrated
its
widespread
presence
non-histone
proteins.
Recently,
high-throughput
proteomics
identified
large
number
lactylated
proteins
sites,
revealing
their
global
regulatory
role
disease
development.
Notably,
this
is
catalyzed
by
lactyltransferase
reversed
delactylase,
with
numerous
new
enzymes,
such
as
AARS1/2,
reported
to
be
involved.
Specifically,
these
revealed
how
lactylation
exerts
influence
through
alterations
spatial
conformation,
molecular
interactions,
enzyme
activity
subcellular
localization.
Indeed,
implicated
various
physiological
pathological
processes,
including
tumor
development,
cardiovascular
cerebrovascular
diseases,
immune
cell
activation
psychiatric
disorders.
This
review
provides
the
latest
advancements
research
roles
lactylation,
highlighting
crucial
scientific
importance
for
future
studies.
ACS Applied Electronic Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
2D
heterostructures,
made
by
stacking
ultrathin
materials,
are
becoming
key
for
advanced
sweat
and
heat
sensors
in
noninvasive
health
monitoring.
These
meticulously
designed
structures
leverage
the
synergistic
properties
of
individual
materials.
Integration
graphene
transition
metal
dichalcogenides
(TMD)
enables
highly
selective
that
monitor
electrolytes,
offering
insights
into
hydration
electrolyte
imbalances.
In
this
regard,
there
is
considerable
versatility
sensor
types,
which
covered
throughout
review.
Some
examples
include
electrochemical
sensors,
enzyme-free,
Joule-heating,
flexible
stretchable,
molecularly
imprinted
polymer
(MIP),
multimodal,
among
others.
On
other
hand,
also
a
plethora
can
be
developed
through
use
heterostructures.
A
widely
explored
material
hexagonal
boron
nitride
(h-BN),
displays
exceptional
thermal
conductivity.
By
combining
h-BN
with
researchers
engineer
heterostructures
accurately
flux,
providing
core
body
temperature
data
thermoregulation
purposes.
However,
challenges
such
as
long-term
stability
biocompatible
integration
remain.
Yet,
sensing
great
terms
types
available,
based
on
thermoresistivity,
expansion,
thermally
induced
phase
change,
optical
heat,
calorimetric,
Even
though
current
to
improvement
their
biocompatibility,
robusticity,
optimization
manufacturing
large-scale
applications,
future
heterostructure-based
bright.
addressing
these
continuously
innovating,
revolutionize
personalized
monitoring,
empower
individuals
track
metrics
real
time,
pave
way
wearable
devices,
ultimately
improving
wellness
management
athletic
performance.
This
review
explores
emerging
applications
heterostructure
nanomaterials
development
The
ability
conveniently
noninvasively
assess
biomarkers
holds
significant
promise
technologies.
discusses
state-of-the-art
material-based
including
recent
advancements
materials
design,
fabrication,
analysis.
Challenges
related
production,
stability,
platforms
discussed.
Finally,
outlines
research
directions,
highlighting
need
developing
cost-effective
fabrication
methods,
integrating
analytics
real-time
monitoring
medicine.
Biosensors,
Год журнала:
2024,
Номер
14(3), С. 148 - 148
Опубликована: Март 18, 2024
Lactate,
once
merely
regarded
as
an
indicator
of
tissue
hypoxia
and
muscular
fatigue,
has
now
gained
prominence
a
pivotal
biomarker
across
various
medical
disciplines.
Recent
research
unveiled
its
critical
role
high-value
prognostic
marker
in
care
medicine.
The
current
practice
lactate
detection
involves
periodic
blood
sampling.
This
approach
is
invasive
confined
to
measurements
at
six-hour
intervals,
leading
resource
expenditure,
time
consumption,
patient
discomfort.
review
addresses
non-invasive
sensors
that
enable
continuous
monitoring
patients.
After
the
introduction,
it
discusses
iontophoresis
system,
followed
by
description
structural
materials
are
universally
employed
create
interface
between
integumentary
system
sensor.
Subsequently,
each
method
detailed
according
physical
principle,
outlining
advantages,
limitations,
pertinent
aspects.
study
concludes
with
discussion
conclusions,
aiming
design
intelligent
sensor
(Internet
Medical
Things
or
IoMT)
facilitate
enhance
clinical
decision-making
support
