Therapeutic potential of extracellular vesicles from diverse sources in cancer treatment
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Июнь 28, 2024
Abstract
Cancer,
a
prevalent
and
complex
disease,
presents
significant
challenge
to
the
medical
community.
It
is
characterized
by
irregular
cell
differentiation,
excessive
proliferation,
uncontrolled
growth,
invasion
of
nearby
tissues,
spread
distant
organs.
Its
progression
involves
interplay
several
elements
processes.
Extracellular
vesicles
(EVs)
serve
as
critical
intermediaries
in
intercellular
communication,
transporting
molecules
such
lipids,
RNA,
membrane,
cytoplasmic
proteins
between
cells.
They
significantly
contribute
progression,
development,
dissemination
primary
tumors
facilitating
exchange
information
transmitting
signals
that
regulate
tumor
growth
metastasis.
However,
EVs
do
not
have
singular
impact
on
cancer;
instead,
they
play
multifaceted
dual
role.
Under
specific
circumstances,
can
impede
influence
cancer
delivering
oncogenic
factors
or
triggering
an
immune
response.
Furthermore,
from
different
sources
demonstrate
distinct
advantages
inhibiting
cancer.
This
research
examines
biological
characteristics
their
involvement
development
establish
theoretical
foundation
for
better
understanding
connection
Here,
we
discuss
potential
various
therapy,
well
current
status
future
prospects
engineered
developing
more
effective
treatments.
Язык: Английский
Direct profiling of breast cancer-derived extracellular vesicles using Pd-perovskite electrochemical biosensing platform
Cancer Nanotechnology,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июнь 13, 2024
Abstract
Extracellular
vesicles
(EVs)
harbor
several
signaling
molecules
to
maintain
intercellular
communication.
Based
on
the
exosomal
cargo
type,
metabolic,
genomic,
and
proteomic
status
of
parent
cells
can
be
investigated.
Due
existence
trivial
levels
target
inside
EVs,
application
accurate
sensitive
detection
methods
is
mandatory.
Here,
we
used
an
electrochemical
immunosensor
using
a
biotinylated
monoclonal
CD63
antibody
as
capturing
element
for
EVs
isolated
from
MDA-MB-231
cancer
patients.
Simultaneously,
breast
biomarker
CA-15-3
was
detected
in
sandwich
method
increase
specificity.
Data
indicated
linear
dynamic
range
2000–10000
EVs/µL
lower
limit
quantification
2000
EVs/µL.
data
real
sample
analysis,
differ
according
severity
systemic
content
this
factor.
Pd-perovskite-based
provides
platform
quick
in-depth
analysis
cells.
Язык: Английский
Exosomes derived from natural killer cells: transforming immunotherapy for aggressive breast cancer
Medical Oncology,
Год журнала:
2025,
Номер
42(4)
Опубликована: Март 18, 2025
Язык: Английский
Fucoxanthin Attenuates Angiogenesis by Blocking the VEGFR2-Mediated Signaling Pathway through Binding the Vascular Endothelial Growth Factor
Guo-Xia Guo,
Yu-Huan Qiu,
Yang Liu
и другие.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 18, 2024
Fucoxanthin,
a
dietary
carotenoid,
is
predominantly
found
in
edible
brown
algae
and
commonly
consumed
worldwide.
Fucoxanthin
has
been
shown
to
possess
beneficial
health
activities
such
as
antidiabetic,
anti-inflammatory,
antimutagenic,
antiobesity;
however,
the
effects
of
fucoxanthin
on
VEGF-mediated
angiogenesis
its
possible
binding
with
VEGF
are
unknown.
Here,
different
lines
evidence
supported
suppressive
roles
angiogenesis.
In
human
umbilical
vein
endothelial
cells,
remarkedly
suppressed
cell
proliferative,
migration,
invasive
abilities,
well
tube
formation,
without
cytotoxicity.
addition,
inhibited
subintestinal
vessel
formation
zebrafish
Язык: Английский
Exosomes and breast cancer angiogenesis; Highlights in intercellular communication
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 18, 2024
Breast
cancer
(BC)
is
a
prevalent
and
highly
lethal
in
females.
Like
other
types,
the
intricate
cellular
molecular
heterogeneity
leads
to
variation
of
therapeutic
outcomes.
The
development
progression
blood
vessels
increase
tumor
cell
expansion
metastasis
remote
sites.
Based
on
several
pieces
scientific
data,
different
mediators
cells
are
involved
promotion
angiogenesis
into
parenchyma.
Recent
data
have
indicated
critical
role
extracellular
vesicles,
especially
exosomes
(Exos),
transfer
molecules
between
BC
cells.
Due
unique
physicochemical
properties,
certain
signaling
molecules,
Exos
at
center
attention
terms
biomarkers
bullets
patients.
Along
with
these
statements,
understanding
modulatory
seems
clinical
setting.
Here,
mechanisms
by
which
can
orchestrate
phenomenon
via
discussed
detail.
present
study
help
us
understand
pro-/anti-angiogenesis
design
better
oncostatic
strategies.
Язык: Английский
Antibacterial composite protein microneedle loaded with hypoxia-treated exosomes for oral ulcer healing
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
99, С. 105952 - 105952
Опубликована: Июль 9, 2024
Язык: Английский
The Chemopreventive Impact of Diet-Derived Phytochemicals on the Adipose Tissue and Breast Tumor Microenvironment Secretome
Nutrition and Cancer,
Год журнала:
2024,
Номер
unknown, С. 1 - 17
Опубликована: Сен. 19, 2024
Cancer
cells-derived
extracellular
vesicles
can
trigger
the
transformation
of
adipose-derived
mesenchymal
stem
cells
(ADMSC)
into
a
pro-inflammatory,
cancer-associated
adipocyte
(CAA)
phenotype.
Such
secretome-mediated
crosstalk
between
adipose
tissue
and
tumor
microenvironment
(TME)
therefore
impacts
progression
metastatic
processes.
In
addition,
emerging
roles
diet-derived
phytochemicals,
especially
epigallocatechin-3-gallate
(EGCG)
among
other
polyphenols,
in
modulating
exosome-mediated
metabolic
inflammatory
signaling
pathways
have
been
highlighted.
Here,
we
discuss
how
selected
phytochemicals
could
alter
secretome
signature
as
well
dynamics
TME,
with
focus
on
breast
cancer.
Their
broader
implication
chemoprevention
obesity-related
cancers
is
also
discussed.
Язык: Английский
Genetically modified extracellular vesicles loaded with activated gasdermin D potentially inhibit prostate-specific membrane antigen-positive prostate carcinoma growth and enhance immunotherapy
Ke Gao,
Wenjin Xi,
Jianxin Ni
и другие.
Biomaterials,
Год журнала:
2024,
Номер
unknown, С. 122894 - 122894
Опубликована: Окт. 1, 2024
Язык: Английский